Self-assembly of Amphiphilic Diblock Copolymers Induced by Liquid-Liquid Phase Separation

Jia-Lu Bai; Dan Liu; Rong Wang

doi:10.1007/s10118-021-2563-6

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Self-assembly of Amphiphilic Diblock Copolymers Induced by Liquid-Liquid Phase Separation

ARTICLE | Updated：2021-05-25

- Self-assembly of Amphiphilic Diblock Copolymers Induced by Liquid-Liquid Phase Separation
- Self-assembly of Amphiphilic Diblock Copolymers Induced by Liquid-Liquid Phase Separation
- Chinese Journal of Polymer Science 2021年39卷第9期页码：1217-1224
- Affiliations：
  
  Department of Polymer Science and Engineering, State Key Laboratory of Coordination Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences, Key Laboratory of High Performance Polymer Material and Technology of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
- Author bio：
  
  wangrong@nju.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 21973041, 21674047, 21474051 and 21734005), the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) and the Fundamental Research Funds for the Central Universities. The numerical calculations have been done on the IBM Blade cluster system in the High Performance Computing Center (HPCC) of Nanjing University.
- DOI：10.1007/s10118-021-2563-6
  中图分类号：
- 收稿：2021-01-16，
  
  修回：2021-2-5，
  
  录用：2021-2-9，
  
  网络首发：2021-05-25，
  
  纸质出版：2021-07-18
- Accepted：
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Bai, J. L.; Liu, D.; Wang, R. Self-assembly of amphiphilic diblock copolymers induced by liquid-liquid phase separation. Chinese J. Polym. Sci. 2021, 39, 1217–1224

Jia-Lu Bai, Dan Liu, Rong Wang. Self-assembly of Amphiphilic Diblock Copolymers Induced by Liquid-Liquid Phase Separation[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1217-1224.
Bai, J. L.; Liu, D.; Wang, R. Self-assembly of amphiphilic diblock copolymers induced by liquid-liquid phase separation. Chinese J. Polym. Sci. 2021, 39, 1217–1224 DOI： 10.1007/s10118-021-2563-6.

Jia-Lu Bai, Dan Liu, Rong Wang. Self-assembly of Amphiphilic Diblock Copolymers Induced by Liquid-Liquid Phase Separation[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1217-1224. DOI： 10.1007/s10118-021-2563-6.

摘要

Abstract

The liquid-liquid phase separation (LLPS) widely exists in biology

synthetic chemistry

crystallization kinetics and other fields

and it is very important to realize the related functions. The research on the competition between LLPS and micellization/vesiculation has made considerable progress. However

the way to effectively control the formation paths from homogeneous state to aggregates has not been completely solved

which is vital to determine its structure and properties and even its future functions. Here we describe the phenomenon of LLPS and its effect on the dynamic process of self-assembly of amphiphilic diblock copolymers (BCPs). Starting from the establishment of phase diagram

we explore the existence conditions of LLPS state

the internal morphology and external size of large droplets

and its significant implications to the dynamic path of vesicle formation. Vesicles formed

via

LLPS have larger sized outer dimensions and inner cavities

and contain more solvents during certain stages. The detailed research of LLPS and its self-assembly simulation has contributed to completing its theoretical basis and practical applications in the future in various fields.

关键词

Keywords

references

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