Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications

Jie Zhou; Xiao-Yuan Zhang; Zhi-Qiang Su

doi:10.1007/s10118-021-2543-x

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Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications

REVIEW | Updated：2021-02-05

- Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications
- Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications
- Chinese Journal of Polymer Science 2021年39卷第9期页码：1093-1109
- Affiliations：
  
  State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing 100029, China
- Author bio：
  
  2020700036@mail.buct.edu.cn (X.Y.Z)
  suzq@mail.buct.edu.cn (Z.Q.S)
- Funds：
  
  ZQS acknowledges the financial supports from the National Natural Science Foundation of China (NSFC, No. 51873016), the Fundamental Research Funds for the Central Universities (No. JD2014), and the Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCT-CJFH) (No. XK2020-11).
- DOI：10.1007/s10118-021-2543-x
  中图分类号：
- 收稿：2020-11-27，
  
  修回：2020-12-17，
  
  录用：2020-12-28，
  
  网络首发：2021-02-05，
  
  纸质出版：2021-07-18
- Accepted：
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Zhou, J.; Zhang, X. Y.; Su, Z. Q. Rational design of biomolecules/polymer hybrids by reversible deactivation radical polymerization (RDRP) for biomedical applications. Chinese J. Polym. Sci. 2021, 39, 1093–1109

Jie Zhou, Xiao-Yuan Zhang, Zhi-Qiang Su. Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1093-1109.
Zhou, J.; Zhang, X. Y.; Su, Z. Q. Rational design of biomolecules/polymer hybrids by reversible deactivation radical polymerization (RDRP) for biomedical applications. Chinese J. Polym. Sci. 2021, 39, 1093–1109 DOI： 10.1007/s10118-021-2543-x.

Jie Zhou, Xiao-Yuan Zhang, Zhi-Qiang Su. Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1093-1109. DOI： 10.1007/s10118-021-2543-x.

摘要

Abstract

Hybrids

produced by hybridization of proteins

peptides

DNA

and other new biomolecules with polymers

often have unique functional properties. These properties

such as biocompatibility

stability and specificity

lead to various smart biomaterials. This review mainly introduces biomolecule-polymer hybrid materials by reversible deactivation radical polymerization (RDRP)

emphasizing reverse addition-fragmentation chain transfer (RAFT) polymerization

and nitroxide mediated polymerization (NMP). It includes the methods of RDRP to improve the biocompatibility of biomedical materials and organisms by surface modification. The key to the current synthesis of biomolecule-polymer hybrids is to control polymerization. Besides

this review describes several different kinds of biomolecule-polymer hybrid materials and their applications in the biomedical field. These progresses provide ideas for the investigation of biodegradable and highly bioactive biomedical soft tissue materials. The research hotspots of nanotechnology in biomedical fields are controlled drug release materials and gene therapy carrier materials. Research showed that RDRP method could improve the therapeutic effect and reduce the dosage and side effects of the drug. Specifically

by means of RDRP

the original materials can be modified to develop intelligent polymer materials as membrane materials with selective permeability and surface modification.

关键词

Keywords

references

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