Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance

Wei-Bin Cai; Dong-Dong Liu; Ying Chen; Li Zhang; Jian-Bo Tan

doi:10.1007/s10118-021-2533-z

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Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance

ARTICLE | Updated：2021-02-01

- Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance
- Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance
- Chinese Journal of Polymer Science 2021年39卷第9期页码：1127-1137
- Affiliations：
  
  a.Department of Polymeric Materials and Engineering, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China
  b.Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, Guangzhou 510006, China
- Author bio：
  
  tanjianbo@gdut.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 21971047 and 21504017) and Innovation Project of Education Department in Guangdong (No. 2018KTSCX053). Y.C. acknowledges the support from Guangdong Special Support Program (No. 2017TX04N371). J.T. acknowledges the support from Pearl River Young Scholar of Guangdong.
- DOI：10.1007/s10118-021-2533-z
  中图分类号：
- 收稿：2020-11-03，
  
  修回：2020-11-24，
  
  录用：2020-11-25，
  
  网络首发：2021-02-01，
  
  纸质出版：2021-07-18
- Accepted：
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Cai, W. B.; Liu, D. D.; Chen, Y.; Zhang, L.; Tan, J. B. Enzyme-assisted photoinitiated polymerization-induced self-assembly in continuous flow reactors with oxygen tolerance. Chinese J. Polym. Sci. 2021, 39, 1127–1137

Wei-Bin Cai, Dong-Dong Liu, Ying Chen, et al. Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1127-1137.
Cai, W. B.; Liu, D. D.; Chen, Y.; Zhang, L.; Tan, J. B. Enzyme-assisted photoinitiated polymerization-induced self-assembly in continuous flow reactors with oxygen tolerance. Chinese J. Polym. Sci. 2021, 39, 1127–1137 DOI： 10.1007/s10118-021-2533-z.

Wei-Bin Cai, Dong-Dong Liu, Ying Chen, et al. Enzyme-assisted Photoinitiated Polymerization-induced Self-assembly in Continuous Flow Reactors with Oxygen Tolerance[J]. Chinese Journal of Polymer Science, 2021, 39(9): 1127-1137. DOI： 10.1007/s10118-021-2533-z.

摘要

Abstract

Polymerization-induced self-assembly (PISA) is an emerging method for the preparation of block copolymer nano-objects at high concentrations. However

most PISA formulations have oxygen inhibition problems and inert atmospheres (

e.g

. argon

nitrogen) are usually required. Moreover

the large-scale preparation of block copolymer nano-objects at room temperature is challenging. Herein

we report an enzyme-assisted photoinitiated polymerization-induced self-assembly (photo-PISA) in continuous flow reactors with oxygen tolerance. The addition of glucose oxidase (GOx) and glucose into the reaction mixture can consume oxygen efficiently and constantly

allow the flow photo-PISA to be performed under open-air conditions. Polymerization kinetics indicated that only a small amount of GOx (0.5 μmol/L) was needed to achieve the oxygen tolerance. Block copolymer nano-objects with different morphologies can be prepared by varying reaction conditions including the degree of polymerization (DP) of core-forming block

monomer concentration

reaction temperature

and solvent composition. We expect this study will provide a facile platform for the large-scale production of block copolymer nano-objects with different morphologies at room temperature.

关键词

Keywords

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