Surface Patterning of Self-healing P(MMA/<italic style="font-style: italic">n</italic>BA) Copolymer for Dynamic Control Cell Behaviors

Su-Su Liu; Ze-Hong Xiang; Zhi-Fang Ma; Xue-Wen Wu; Qiang Shi; Shing-Chung Wong; Jing-Hua Yin

doi:10.1007/s10118-020-2382-1

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Surface Patterning of Self-healing P(MMA/nBA) Copolymer for Dynamic Control Cell Behaviors

ARTICLE | Updated：2020-02-25

- Surface Patterning of Self-healing P(MMA/nBA) Copolymer for Dynamic Control Cell Behaviors
- Surface Patterning of Self-healing P(MMA/nBA) Copolymer for Dynamic Control Cell Behaviors
- Chinese Journal of Polymer Science 2020年38卷第7期页码：696-703
- Affiliations：
  
  a.School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China
  b.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Department of Mechanical Engineering, University of Akron, Ohio 44325-3903, USA
- Author bio：
  
  wxw@xtu.edu.cn (X.W.W.)
  shiqiang@ciac.ac.cn (Q.S.)
- Funds：
  
  This work was financially supported by the National Key Research and Development Program of China (No. 2016YFC1100402), the National Natural Science Foundation of China (Nos. 51973222 and 51573186), the Natural Science Foundation of Jilin Province of China (Nos. 20180101178JC and 20190701030GH), and Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, CIAC, CAS (Nos. 201826 and 201715).
- DOI：10.1007/s10118-020-2382-1
  中图分类号：
- 收稿：2019-10-22，
  
  修回：2019-12-17，
  
  录用：2019-12-19，
  
  网络首发：2020-02-25，
  
  纸质出版：2020-07
- Accepted：
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Liu, S. S.; Xiang, Z. H.; Ma, Z. F.; Wu, X. W.; Shi, Q.; Wong, S. C.; Yin, J. H. Surface patterning of self-healing P(MMA/, n,BA) copolymer for dynamic control cell behaviors. Chinese J. Polym. Sci. 2020, 38, 696–703

Su-Su Liu, Ze-Hong Xiang, Zhi-Fang Ma, et al. Surface Patterning of Self-healing P(MMA/nBA) Copolymer for Dynamic Control Cell Behaviors[J]. Chinese Journal of Polymer Science, 2020, 38(7): 696-703. DOI: 10.1007/s10118-020-2382-1.
Liu, S. S.; Xiang, Z. H.; Ma, Z. F.; Wu, X. W.; Shi, Q.; Wong, S. C.; Yin, J. H. Surface patterning of self-healing P(MMA/, n,BA) copolymer for dynamic control cell behaviors. Chinese J. Polym. Sci. 2020, 38, 696–703 DOI： 10.1007/s10118-020-2382-1.

Su-Su Liu, Ze-Hong Xiang, Zhi-Fang Ma, et al. Surface Patterning of Self-healing P(MMA/nBA) Copolymer for Dynamic Control Cell Behaviors[J]. Chinese Journal of Polymer Science, 2020, 38(7): 696-703. DOI: 10.1007/s10118-020-2382-1. DOI：

摘要

Abstract

Cell behaviors are regulated by a dynamic and complex environment characterized by biophysical

mechanical and biochemical properties. However

most works regulate cell behaviors under static conditions or by external factors. To control cell adhesion and proliferation with a dynamic and mechanical environment

we pattern the surface on self-healing copolymer P(MMA/

BA). The copolymer P(MMA/

BA) with the composition of 48/52 (MMA/

BA) recovers nearly 100% of its original tensile strains after 86 h of recovery from deformation. The physical patterns on P(MMA/

BA) film are obtained over large areas and the size of the hole and the width of connecting bar are in line with the copper grid specifications. The patterned surface tends to be flat after 12 h with almost 75%−80% recovery. Compared with cell incubation on polystyrene flat and patterned surface of P(MMA/

BA) film without self-healing capability

the number and morphology of cells are well manipulated on the patterned surface of self-healing P(MMA/

BA) film. This approach provides a convenient method for dynamically regulating the cell behaviors on the surface of self-healing materials without chemical or biological modifications.

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Surface Patterning of Self-healing P(MMA/nBA) Copolymer for Dynamic Control Cell Behaviors

Surface Patterning of Self-healing P(MMA/nBA) Copolymer for Dynamic Control Cell Behaviors

DOI：10.1007/s10118-020-2382-1

摘要

Abstract

关键词

Keywords

references