Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy

Heng-Ye Gong; Yan-Gui Chen; Xing-Su Yu; Hong Xiao; Jin-Peng Xiao; Yong Wang; Xin-Tao Shuai

doi:10.1007/s10118-019-2272-6

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Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy

ARTICLE | Updated：2021-02-18

- Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy
- Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy
- Chinese Journal of Polymer Science 2019年37卷第12期页码：1224-1233
- Affiliations：
  
  a.PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China
  b.HEC Pharma Co., Ltd., Dongguan 523871, China
  c.Reproductive Center, Guangdong Women's Health Care Center, Guangzhou 511400, China
- Author bio：
  
  shuaixt@mail.sysu.edu.cn
- Funds：
  
  This work was financially supported by the National Basic Research Program of China (No. 2015CB755500), the Natural Science Foundation of Guangdong Province (No. 2014A030312018), and Science and Technology Planning Project of Guangdong Province (No. 2016A020215088).
- DOI：10.1007/s10118-019-2272-6
  中图分类号： M
- 收稿：2019-03-17，
  
  修回：2019-4-3，
  
  录用：2019-4-8，
  
  网络首发：2019-06-04，
  
  纸质出版：2019-12
- Accepted：
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Gong, H. Y.; Chen, Y. G.; Yu, X. S.; Xiao, H.; Xiao, J. P.; Wang, Y.; Shuai, X. T. Co-delivery of doxorubicin and afatinib with pH-responsive polymeric nanovesicle for enhanced lung cancer therapy. Chinese J. Polym. Sci. 2019, 37, 1224–1233.

Heng-Ye Gong, Yan-Gui Chen, Xing-Su Yu, et al. Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy[J]. Chinese Journal of Polymer Science, 2019, 37(12): 1224-1233.
Gong, H. Y.; Chen, Y. G.; Yu, X. S.; Xiao, H.; Xiao, J. P.; Wang, Y.; Shuai, X. T. Co-delivery of doxorubicin and afatinib with pH-responsive polymeric nanovesicle for enhanced lung cancer therapy. Chinese J. Polym. Sci. 2019, 37, 1224–1233. DOI： 10.1007/s10118-019-2272-6.

Heng-Ye Gong, Yan-Gui Chen, Xing-Su Yu, et al. Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy[J]. Chinese Journal of Polymer Science, 2019, 37(12): 1224-1233. DOI： 10.1007/s10118-019-2272-6.

摘要

Abstract

Drug-resistance and drastic side effects are two major issues of traditional chemotherapy which may result in trail failure even death. Nanoparticle-mediated multidrug combination treatment has been proven to be a feasible strategy to overcome these challenges. In the present study

amphipathic block polymer of methoxyl poly(ethylene glycol)-poly(aspartyl(dibutylethylenediamine)-

-phenylalanine) (mPEG-P(Asp(DBA)-

-Phe)) was synthesized and self-assembled into pH-responsive polymeric vesicle. The vesicle was utilized to co-deliver cancer-associated epidermal growth factor (EGFR) inhibitor of afatinib and DNA-damaging chemotherapeutic doxorubicin hydrochloride (DOX) for enhanced non-small-cell lung cancer (NSCLC) therapy. As evaluated

in vitro

the pH-responsive design of nanovesicle resulted in a rapid release of encapsulated drugs into tumor cells and caused enhanced cell apoptosis. In addition

in vivo

therapeutic studies were conducted and the results evidenced that the co-delevery of DOX and afatinib using pH-sensitive nanovector was a promising strategy for NSCLC treatment.

关键词

Keywords

references

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