Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering

Tian-Fu Li; Yi-Yun Cheng; Yu Wang; Hui Wang; Dong-Feng Chen; Yun-Tao Liu; Li Zhang; Wen-Ze Han; Rong-Deng Liu; Zi-Jun Wang; Chun-Ming Yang; Charl J. Jafta; Daniel Clemens; Uwe Keiderling

doi:10.1007/s10118-019-2260-x

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Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering

ARTICLE | Updated：2021-02-18

- Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering
- Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering
- Chinese Journal of Polymer Science 2019年37卷第8期页码：827-833
- Affiliations：
  
  a.China Institute of Atomic Energy, Beijing 102413, China
  b.Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200062, China
  c.Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China
  d.Helmholtz-Zentrum Berlin fürMaterialien und Energie, Lise-Meitner-Campus, Berlin 14109, Germany
- Author bio：
  
  litianfu.li@163.com (T.F.L.)
  yycheng@mail.ustc.edu.cn (Y.Y.C.)
- Funds：
  
  We thank HZB for the allocation of neutron beamtime. TF Li is grateful to Prof. Dr. Matthias Ballauff and Dr. Roland Steitz for their support in hosting him as a visiting researcher at HZB. We thank Dr. Ben Kent for his support with the neutron experiments. This research was financially supported by the National Natural Science Foundation of China (Nos. 11475267, 11005159, and 21725402).
- DOI：10.1007/s10118-019-2260-x
  中图分类号：
- 收稿：2019-01-30，
  
  修回：2019-3-9，
  
  录用：2019-3-21，
  
  网络首发：2019-04-25，
  
  纸质出版：2019-08
- Accepted：
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Citation: Li, T. F.; Cheng, Y. Y.; Wang, Y.; Wang, H.; Chen, D. F.; Liu, Y. T.; Zhang, L.; Han, W. Z.; Liu, R. D.; Wang, Z. J.; Yang, C. M.; Jafta, C. J.; Clemens, D.; Keiderling, U. Analysis of dimer impurity in polyamidoamine dendrimer solutions by small-angle neutron scattering. Chinese J. Polym. Sci. 2019, 37, 827–833

Tian-Fu Li, Yi-Yun Cheng, Yu Wang, et al. Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering[J]. Chinese Journal of Polymer Science, 2019, 37(8): 827-833.
Citation: Li, T. F.; Cheng, Y. Y.; Wang, Y.; Wang, H.; Chen, D. F.; Liu, Y. T.; Zhang, L.; Han, W. Z.; Liu, R. D.; Wang, Z. J.; Yang, C. M.; Jafta, C. J.; Clemens, D.; Keiderling, U. Analysis of dimer impurity in polyamidoamine dendrimer solutions by small-angle neutron scattering. Chinese J. Polym. Sci. 2019, 37, 827–833 DOI： 10.1007/s10118-019-2260-x.

Tian-Fu Li, Yi-Yun Cheng, Yu Wang, et al. Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering[J]. Chinese Journal of Polymer Science, 2019, 37(8): 827-833. DOI： 10.1007/s10118-019-2260-x.

摘要

Abstract

Dimer impurity in the solution of a generation five (G5) polyamidoamine (PAMAM) dendrimer has been investigated by small-angle neutron scattering (SANS). The existence of dimer impurity in dendrimer solution was evidenced by indirect Fourier transform (IFT) analysis of the SANS data

in which the maximum dimension of particles in solution was found to be about twice the diameter of G5 dendrimer. We then developed an analytical model which accounts for the scattering contribution from both dendrimer monomer and dimer. The experimental data were well fitted by using the established model. The results showed that the amount of dimer impurities is significant for the measured three batches of G5 PAMAM dendrimers.

关键词

Keywords

references

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