Electrospun Poly(<italic style="font-style: italic">p</italic>-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction

Juan Du; Ji-Hu Wang; Hai-Yan Yu; Yan-Yan Zhang; Li-Hui Pu; Jin-Cheng Wang; Shu-Yang Lu; Si-Hao Chen; Tong-He Zhu

doi:10.1007/s10118-019-2231-2

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Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction

ARTICLE | Updated：2021-02-18

- Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction
- Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction
- Chinese Journal of Polymer Science 2019年37卷第6期页码：560-569
- Affiliations：
  
  a.College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
  b.State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
  c.Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
  d.Shanghai Institute of Cardiovascular Disease, Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Author bio：
  
  chensh@sues.edu.cn (S.H.C.)
  zhutonghe89@163.com (T.H.Z.)
- Funds：
  
  This work was financially supported by the Capacity Building Project of Some Local Colleges and Universities in Shanghai (No. 17030501200), the National Natural Science Foundation of China (No. 81501595), Youth Foundation of Zhongshan Hospital (No. 2015ZSQN09), Talent Training Program Foundation for the Excellent Youth Supported by Zhongshan Hospital (No. 2017ZSYQ24), and Innovation Fund of Zhongshan Hospital (No. 2017ZSCX05).
- DOI：10.1007/s10118-019-2231-2
  中图分类号：
- 收稿：2018-12-23，
  
  修回：2019-1-19，
  
  录用：2019-1-22，
  
  网络首发：2019-02-27，
  
  纸质出版：2019-06
- Accepted：
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Citation: Du, J.; Wang, J. H.; Yu, H. Y.; Zhang, Y. Y.; Pu, L. H.; Wang, J. C.; Lu, S. Y.; Chen, S. H.; Zhu, T. H. Electrospun poly(p-dioxanone)/,poly(ester-urethane)ureas composite nanofibers for potential heart valve tissue reconstruction. Chinese J. Polym. Sci. 2019, 37, 560–569

Juan Du, Ji-Hu Wang, Hai-Yan Yu, et al. Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction[J]. Chinese Journal of Polymer Science, 2019, 37(6): 560-569. DOI: 10.1007/s10118-019-2231-2.
Citation: Du, J.; Wang, J. H.; Yu, H. Y.; Zhang, Y. Y.; Pu, L. H.; Wang, J. C.; Lu, S. Y.; Chen, S. H.; Zhu, T. H. Electrospun poly(p-dioxanone)/,poly(ester-urethane)ureas composite nanofibers for potential heart valve tissue reconstruction. Chinese J. Polym. Sci. 2019, 37, 560–569 DOI： 10.1007/s10118-019-2231-2.

Juan Du, Ji-Hu Wang, Hai-Yan Yu, et al. Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction[J]. Chinese Journal of Polymer Science, 2019, 37(6): 560-569. DOI: 10.1007/s10118-019-2231-2. DOI：

摘要

Abstract

Electrospun nanofibrous mats represent a new generation of medical textiles with promising applications in heart valve tissue reconstruction. It is important for biomaterials to mimic the biological and mechanical microenvironment of native extracellular matrix (ECM). However

the major challenges are still remaining for current biomedical materials

including appropriate mechanical properties

biocompatibility

and hemocompatibility. In the present work

the novel composite nanofibrous mats of poly(

-dioxanone) (PDO) and poly(ester-urethane)ureas (PEUU) are fabricated by electrospinning system. The optimal combination ratio of PDO to PEUU may balance the mechanical properties and cellular compatibility to match the newly formed tissue. In PDO/PEUU composite nanofibrous mats

PEUU can provide the biomimetic elastomeric behavior

and PDO could endow the excellent biocompatibility. In comparison to nanofibrous mat of neat PDO

the composite showed significantly improved mechanical properties

with 5-fold higher initial elongation at break. Furthermore

human umbilical vein endothelial cells (HUVECs) were cultured on the composite to evaluate its ability to rapidly endothelialize as heart valve tissue engineering. The results revealed that PDO/PEUU composite nanofibrous mats could promote cell adhesion and proliferation

especially for the ratio of 60/40. Overall

PDO/PEUU composite nanofibrous mats (60/40) show the excellent mechanical properties

appropriate biocompatibility and hemocompatibility which meet the necessary norm for tissue engineering and may be suitable for potential heart valve tissue reconstruction.

关键词

Keywords

references

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Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction

DOI：10.1007/s10118-019-2231-2

摘要

Abstract

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Keywords

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