Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release

Xiao-Qiu Dou; Chang-Li Zhao; Nabila Mehwish; Ping Li; Chuan-Liang Feng; Holger Schönherr

doi:10.1007/s10118-019-2223-2

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Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release

ARTICLE | Updated：2021-02-18

- Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release
- Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release
- Chinese Journal of Polymer Science 2019年37卷第5期页码：437-443
- Affiliations：
  
  a.Physical Chemistry I and Research Center of Micro and Nanochemistry and Engineering (Cμ), Department of Chemistry and Biology, University of Siegen, Siegen 57076, Germany
  b.State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
- Author bio：
  
  clfeng@sjtu.edu.cn (C.L.F.)
  schoenherr@chemie.uni-siegen.de (H.S.)
- Funds：
  
  This work was financially supported by the Alexander von Humboldt Foundation (postdoc stipend to X. Q. Dou), the European Research Council (No. 279202), and the National Natural Science Foundation of China (Nos. 51833006 and 51573092). We thank Dipl.-Ing. Gregor Schulte for his technical support, as well as Prof. Dr. Ulrich Jonas, Dipl.-Labchem. Petra Frank (Macromolecular Chemistry, Department Chemistry – Biology, University of Siegen), who kindly granted access to ATR-FTIR measurement, and Prof. Dr. Heiko Ihmels (Organic Chemistry II, University of Siegen) who kindly provided access to the CD measurement.
- DOI：10.1007/s10118-019-2223-2
  中图分类号：
- 收稿：2018-12-11，
  
  修回：2018-12-28，
  
  录用：2019-1-7，
  
  网络首发：2019-02-18，
  
  纸质出版：2019-05
- Accepted：
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Citation: Dou, X. Q.; Zhao, C. L.; Mehwish, N.; Li, P.; Feng, C. L.; Schönherr, H. Photoresponsive supramolecular hydrogel co-assembled from Fmoc-Phe-OH and 4,4′-azopyridine for controllable dye release. Chinese J. Polym. Sci. 2019, 37, 437–443

Xiao-Qiu Dou, Chang-Li Zhao, Nabila Mehwish, et al. Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release[J]. Chinese Journal of Polymer Science, 2019, 37(5): 437-443.
Citation: Dou, X. Q.; Zhao, C. L.; Mehwish, N.; Li, P.; Feng, C. L.; Schönherr, H. Photoresponsive supramolecular hydrogel co-assembled from Fmoc-Phe-OH and 4,4′-azopyridine for controllable dye release. Chinese J. Polym. Sci. 2019, 37, 437–443 DOI： 10.1007/s10118-019-2223-2.

Xiao-Qiu Dou, Chang-Li Zhao, Nabila Mehwish, et al. Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release[J]. Chinese Journal of Polymer Science, 2019, 37(5): 437-443. DOI： 10.1007/s10118-019-2223-2.

摘要

Abstract

Photoresponsive hydrogels have been attractive because they can provide precise spatial and temporal control for molecule release

whereas the conventional preparation of photoresponsive hydrogels generally involves complex chemical synthesis steps or specific conditions which limits their practical applications. Herein

a new photoresponsive hydrogel is facilely prepared

via

co-assembly of two simple molecules

Fmoc-Phe-OH and Azp

without chemical synthesis. The co-assembly mechanism

morphology

and photoresponsiveness of (Fmoc-Phe-OH)-Azp hydrogel are investigated by circular dichroism (CD)

ultraviolet-visible (UV-Vis)

fluorescence

H nuclear magnetic resonance (

H-NMR)

attenuated total internal reflection Fourier transform Infrared (ATR-FTIR) spectroscopy

and scanning electron microscopy (SEM). Furthermore

the enhanced release of encapsulated sulforhodamine B (SRB) dye molecules can be achieved

via

UV light irradiation. The enhanced dye release amount can be controlled by manipulating photoirradiation time. This study provides a facile way to prepare photoresponsive hydrogel which holds great potential for controllable drug release.

关键词

Keywords

references

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