Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing

Wei-Ke Xu; Jing-Yu Tang; Zhang Yuan; Cai-Yun Cai; Xiao-Bin Chen; Shu-Quan Cui; Peng Liu; Lin Yu; Kai-Yong Cai; Jian-Dong Ding

doi:10.1007/s10118-019-2212-5

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Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing

ARTICLE | Updated：2021-02-18

- Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing
- Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing
- Chinese Journal of Polymer Science 2019年37卷第6期页码：548-559
- Affiliations：
  
  a.State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China
  b.Key Laboratory of Biorheological Science and Technology Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
- Author bio：
  
  yu_lin@fudan.edu.cn
- Funds：
  
  The work was financially supported by the National Natural Science Foundation of China (Nos. 51773043, 81772363, and 21474019), National Key R&D Program of China (No. 2016YFC1100300), and China Postdoctoral Science Foundation (No. 2018M632020).
- DOI：10.1007/s10118-019-2212-5
  中图分类号：
- 收稿：2018-11-17，
  
  修回：2018-12-9，
  
  录用：2018-12-11，
  
  网络首发：2019-01-11，
  
  纸质出版：2019-06
- Accepted：
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Citation: Xu, W. K.; Tang, J. Y.; Yuan, Z.; Cai, C. Y.; Chen, X. B.; Cui, S. Q.; Liu, P.; Yu, L.; Cai, K. Y.; Ding, J. D. Accelerated cutaneous wound healing using an injectable teicoplanin-loaded PLGA-PEG-PLGA thermogel dressing. Chinese J. Polym. Sci. 2019, 37, 548–559

Wei-Ke Xu, Jing-Yu Tang, Zhang Yuan, et al. Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing[J]. Chinese Journal of Polymer Science, 2019, 37(6): 548-559.
Citation: Xu, W. K.; Tang, J. Y.; Yuan, Z.; Cai, C. Y.; Chen, X. B.; Cui, S. Q.; Liu, P.; Yu, L.; Cai, K. Y.; Ding, J. D. Accelerated cutaneous wound healing using an injectable teicoplanin-loaded PLGA-PEG-PLGA thermogel dressing. Chinese J. Polym. Sci. 2019, 37, 548–559 DOI： 10.1007/s10118-019-2212-5.

Wei-Ke Xu, Jing-Yu Tang, Zhang Yuan, et al. Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing[J]. Chinese Journal of Polymer Science, 2019, 37(6): 548-559. DOI： 10.1007/s10118-019-2212-5.

摘要

Abstract

Bacterial infection is a very troublesome issue in wound treatment

which stimulates exudate formation and severely delays the healing process. Herein

a thermogelling dressing system composed of two triblock copolymers of poly(D

L-lactic acid-

-glycolic acid)-

-poly(ethylene glycol)-

-poly(D

L-lactic acid-

-glycolic acid) (PLGA-PEG-PLGA) with different block lengths was developed to deliver teicoplanin (TPN)

a glycopeptide antibiotic

for cutaneous wound repair. The TPN-loaded thermogel was a free-flowing sol at room temperature and formed a semi-solid gel at physiological temperature.

In vitro

studies demonstrated that the TPN-loaded thermogel system exhibited desired tissue adhesiveness and realized the sustained release of TPN in a fast-followed-slow manner for over three weeks. Furthermore

a full-thickness excision wound model in Sprague-Dawley (SD) rats was constructed to assess the efficacy of TPN-loaded thermogel formulation. Gross and histopathologic observations implied that treatment with the thermogel formulation reduced inflammation response

promoted disposition of collagen

enhanced angiogenesis

and accelerated wound closure and maturity of SD rats. The combination of the bioactivity of TPN and the acidic nature of the thermogel matrix was responsible for such an enhanced wound healing process. Consequently

the TPN-loaded PLGA-PEG-PLGA thermogel is a good candidate of wound dressing for full-thickness excision wound healing.

关键词

Keywords

references

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