NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging

Lei-Jing Liu; Wen Liu; Guang Ji; Zhi-Yuan Wu; Bin Xu; Jun Qian; Wen-Jing Tian

doi:10.1007/s10118-019-2206-3

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NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging

ARTICLE | Updated：2021-02-18

- NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging
- NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging
- Chinese Journal of Polymer Science 2019年37卷第4期页码：401-408
- Affiliations：
  
  a.State Key Lab for Supramolecular Structure and Materials, Jilin University, Changchun 130012, China
  b.State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, JORCEP (Sino-Swedish Joint Research Center of Photonics), Zhejiang University, Hangzhou 310058, China
- Author bio：
  
  qianjun@zju.edu.cn (J.Q.)
  wjtian@jlu.edu.cn (W.J.T.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 21835001, 51773080, 21674041, 51573068, and 21221063), Program for Changbaishan Scholars of Jilin Province, Jilin Province (No. 20160101305JC), and the “Talents Cultivation Program” of Jilin University.
- DOI：10.1007/s10118-019-2206-3
  中图分类号：
- 收稿：2018-10-24，
  
  修回：2018-12-3，
  
  录用：2018-12-9，
  
  网络首发：2019-01-10，
  
  纸质出版：2019-04
- Accepted：
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Citation: Liu, L. J.; Liu, W.; Ji, G.; Wu, Z. Y.; Xu, B.; Qian, J.; Tian, W. J. NIR emission nanoparticles based on FRET composed of AIE luminogens and NIR dyes for two-photon fluorescence imaging. Chinese J. Polym. Sci. 2019, 37, 401–408

Lei-Jing Liu, Wen Liu, Guang Ji, et al. NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging[J]. Chinese Journal of Polymer Science, 2019, 37(4): 401-408.
Citation: Liu, L. J.; Liu, W.; Ji, G.; Wu, Z. Y.; Xu, B.; Qian, J.; Tian, W. J. NIR emission nanoparticles based on FRET composed of AIE luminogens and NIR dyes for two-photon fluorescence imaging. Chinese J. Polym. Sci. 2019, 37, 401–408 DOI： 10.1007/s10118-019-2206-3.

Lei-Jing Liu, Wen Liu, Guang Ji, et al. NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging[J]. Chinese Journal of Polymer Science, 2019, 37(4): 401-408. DOI： 10.1007/s10118-019-2206-3.

摘要

Abstract

Near-infrared (NIR) nanoparticles (NPs) based on fluorescence resonance energy transfer (FRET) were prepared by co-encapsulation of a red aggregation-induced emission (AIE) molecule

2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile (TB)

and a commercial NIR fluorescence dye

silicon 2

3-naphthalocyanine bis(trihexylsilyloxide) (NIR775) with an amphiphilic polymer poly(styrene-

-maleic anhydride) (PSMA). The surface of the NPs

PSMA@TB/NIR775

was modified with poly(ethylene glycol) (PEG) to increase the

in vivo

biocompatibility of the NPs. The PSMA@TB/NIR775 NPs showed a strong NIR (780 nm) narrow emission and excellent two-photon absorption property. Moreover

the NPs exhibited good monodispersity

stability

and low cytotoxicity. Under the excitation of a 1040 nm femtosecond (fs) laser

the emission peaks at 680 nm of TB and 780 nm of NIR775 excited by FRET were obtained. We utilized PSMA@TB/NIR775 NPs as fluorescent contrast agents for two-photon excited NIR microscopic imaging

and good NIR imaging effect of mouse brain vasculature was obtained with the imaging depth of about 150 µm. The FRET strategy by co-encapsulating AIE molecule and NIR dye will be helpful in preparing more narrow emission NIR probes for deep-tissue biological imaging.

关键词

Keywords

references

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