pH-responsive Micelles from a Blend of PEG-<italic style="font-style: italic">b</italic>-PLA and PLA-<italic style="font-style: italic">b</italic>-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation

Yan-Ling Xu; Ao-Ting Qu; Ru-Jiang Ma; Ang Li; Zhen-Kun Zhang; Zhi-Qiang Shang; Yao-Fang Zhang; Lu-Xia Bu; Ying-Li An

doi:10.1007/s10118-018-2149-0

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pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation

ARTICLE | Updated：2021-02-18

- pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation
- pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation
- Chinese Journal of Polymer Science 2018年36卷第11期页码：1262-1268
- Affiliations：
  
  a.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China
  b.College of Basic Science, Chemistry Experiment Teaching Center, Tianjin Agricultural University, Tianjin 300384, China
- Author bio：
  
  anyingli@nankai.edu.cn
- Funds：
  
  The financial supports by the National Natural Science Foundation of China (Nos. 21404082 and 51503104), the State Key Laboratory of Medicinal Chemical Biology of China (No. 201603001) and Natural Science Foundation of Tianjin (Nos. 15JCQNJC05900, 15JCQNJC13400 and 16JCQNJC03000) are gratefully acknowledged.
- DOI：10.1007/s10118-018-2149-0
  中图分类号：
- 收稿：2018-03-04，
  
  修回：2018-4-25，
  
  录用：2018-5-16，
  
  网络首发：2018-06-14，
  
  纸质出版：2018-11
- Accepted：
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Citation: Xu, Y. L.; Qu, A. T.; Ma, R. J.; Li, A.; Zhang, Z. K.; Shang, Z. Q.; Zhang, Y. F.; Bu, L. X.; An, Y. L. pH-responsive Micelles from a Blend of PEG- b-PLA and PLA- b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation. Chinese J. Polym. Sci. 2018, 36(11), 1262–1268.

Yan-Ling Xu, Ao-Ting Qu, Ru-Jiang Ma, et al. pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation[J]. Chinese Journal of Polymer Science, 2018, 36(11): 1262-1268. DOI: 10.1007/s10118-018-2149-0.
Citation: Xu, Y. L.; Qu, A. T.; Ma, R. J.; Li, A.; Zhang, Z. K.; Shang, Z. Q.; Zhang, Y. F.; Bu, L. X.; An, Y. L. pH-responsive Micelles from a Blend of PEG- b-PLA and PLA- b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation. Chinese J. Polym. Sci. 2018, 36(11), 1262–1268. DOI： 10.1007/s10118-018-2149-0.

Yan-Ling Xu, Ao-Ting Qu, Ru-Jiang Ma, et al. pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation[J]. Chinese Journal of Polymer Science, 2018, 36(11): 1262-1268. DOI: 10.1007/s10118-018-2149-0. DOI：

摘要

Abstract

pH-responsive micelles with a biodegradable PLA core and a mixed PEG/PDPA shell were prepared by self-assembly of poly(ethylene glycol)-

-poly(lactic acid) (PEG-

-PLA) and poly(2-(diisopropylamino)ethyl methacrylate)-

-poly(lactic acid) (PDPA-

-PLA). The micellization status with different pH and the enzyme degradation behavior were characterized by

H-NMR spectroscopy

dynamic light scattering measurement and zeta potential test. The pH turning point of PDPA block was determined to be in the range of 5.5−7.0. While the pH was above 7.0

the PDPA block collapsed onto the PLA core and could protect the PLA core from invasion of enzyme

as a result

the micelle exhibited a resistance to the enzymatic degradation.

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Keywords

references

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pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation

pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation

DOI：10.1007/s10118-018-2149-0

摘要

Abstract

关键词

Keywords

references