Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography

Yi Huang; Xiao-Xia Li; Lu Zhang; Xiao-Yan Chen; Cheng-Bo Liu; Jing-Qin Chen; Yong Wang; Xin-Tao Shuai

doi:10.1007/s10118-018-2141-8

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Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography

ARTICLE | Updated：2021-02-18

- Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography
- Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography
- Chinese Journal of Polymer Science 2018年36卷第10期页码：1139-1149
- Affiliations：
  
  a.PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China
  b.Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
- Author bio：
  
  wangy488@mail.sysu.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (No. U1401242), National Basic Research Program of China (No. 2015CB755500), Natural Science Foundation of the Guangdong Province (No. 2014A030312018) and the Fundamental Research Funds for the Central Universities (Nos. 17lgjc01 and 17lgpy08).
- DOI：10.1007/s10118-018-2141-8
  中图分类号：
- 收稿：2018-02-27，
  
  修回：2018-3-23，
  
  录用：2018-4-2，
  
  网络首发：2018-05-10，
  
  纸质出版：2018-10
- Accepted：
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Citation: Huang, Y.; Li, X. X.; Zhang, L.; Chen, X. Y.; Liu, C. B.; Chen, J. Q.; Wang, Y.; Shuai, X. T. Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography. Chinese J. Polym. Sci. 2018, 36(10), 1139–1149.

Yi Huang, Xiao-Xia Li, Lu Zhang, et al. Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography[J]. Chinese Journal of Polymer Science, 2018, 36(10): 1139-1149.
Citation: Huang, Y.; Li, X. X.; Zhang, L.; Chen, X. Y.; Liu, C. B.; Chen, J. Q.; Wang, Y.; Shuai, X. T. Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography. Chinese J. Polym. Sci. 2018, 36(10), 1139–1149. DOI： 10.1007/s10118-018-2141-8.

Yi Huang, Xiao-Xia Li, Lu Zhang, et al. Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography[J]. Chinese Journal of Polymer Science, 2018, 36(10): 1139-1149. DOI： 10.1007/s10118-018-2141-8.

摘要

Abstract

Photothermo-chemotherapy

as a new strategy for cancer treatment

incorporates the complementary advantages of photothermal therapy and chemotherapy. In this study

a pH-sensitive diblock copolymer poly(aspartic acid-butanediamine)-poly(2-(diisopropylamino)ethyl methacrylate) (PAsp(DAB)-PDPA) was synthesized and self-assembled into doxorubicin-loaded micelle

which was further used as a template to form a gold nanoshell. After further modification with poly(ethylene glycol)

the resulting nanoplatform provided good biocompatibility and desirable photo-thermal conversion efficiency to facilitate photothermal therapy. Meanwhile the nanoparticle also exhibited pH sensitivity

which prevented drug loss while circulating in the blood but enabled rapid drug release after endocytosis. An improved effect was achieved with the combination of photothermal therapy and chemotherapy. In addition

systemic delivery of the nanoplatform could be monitored by photoacoustic tomography. Thereby

this multifunctional nanoplatform would be highly potential for the diagnosis and therapy of cancer.

关键词

Keywords

references

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