Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides

Vadim V. Annenkov; Uma Maheswari Krishnan; Viktor A. Pal'shin; Stanislav N. Zelinskiy; Gayathri Kandasamy; Elena N. Danilovtseva

doi:10.1007/s10118-018-2133-8

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Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides

ARTICLE | Updated：2021-02-18

- Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides
- Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides
- Chinese Journal of Polymer Science 2018年36卷第10期页码：1114-1122
- Affiliations：
  
  a.Limnological Institute of the Siberian Branch of the Russian Academy of Sciences, 3, Ulan-Batorskaya St., P.O. Box 278, Irkutsk, 664033, Russia
  b.Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical and Biotechnology, SASTRA University, Thanjavur – 613401, Tamil Nadu, India
- Author bio：
  
  annenkov@lin.irk.ru
- Funds：
  
  We acknowledge financial support from a joint grant of the Russian Science Foundation (# 6-45-02001) and the Department of Science Technology of the Ministry of Science and Technology of the Republic of India (# INT/RUS/RSF/10).
- DOI：10.1007/s10118-018-2133-8
  中图分类号：
- 收稿：2018-01-18，
  
  修回：2018-2-25，
  
  录用：2018-3-3，
  
  网络首发：2018-04-19，
  
  纸质出版：2018-10
- Accepted：
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Citation: Annenkov, V. V.; Krishnan, U. M.; Pal'shin, V. A.; Zelinskiy. S. N.; Kandasamy, G.; Danilovtseva, E. N. Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides. Chinese J. Polym. Sci. 2018, 36(10), 1114–1122.

Vadim V. Annenkov, Uma Maheswari Krishnan, Viktor A. Pal'shin, et al. Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides[J]. Chinese Journal of Polymer Science, 2018, 36(10): 1114-1122.
Citation: Annenkov, V. V.; Krishnan, U. M.; Pal'shin, V. A.; Zelinskiy. S. N.; Kandasamy, G.; Danilovtseva, E. N. Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides. Chinese J. Polym. Sci. 2018, 36(10), 1114–1122. DOI： 10.1007/s10118-018-2133-8.

Vadim V. Annenkov, Uma Maheswari Krishnan, Viktor A. Pal'shin, et al. Bioinspired Water-soluble Polymers with Grafted Polyamine Chains: Synthesis and Complexation with Oligonucleotides[J]. Chinese Journal of Polymer Science, 2018, 36(10): 1114-1122. DOI： 10.1007/s10118-018-2133-8.

摘要

Abstract

The siliceous frustules of diatom algae contain complex proteins known as silaffins

which consist of a peptide chain with grafted polyamine chains. These polyamines contain twenty or more nitrogen atoms with trimethylene groups between the nitrogens. We synthesized a set of polymers containing grafted long-chain polyamine fragments by using acryloyl chloride (ACh) polymers and activated acrylic acid copolymers as the starting materials. The new polymers contained 0.05 mol%−3.2 mol% of polyamine chains

which corresponded to 0.06−3.56 mmol·g

−1

amine groups. The new amine-containing polymers formed complexes with short (19-21-mer) deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) strands

and these complexes penetrated into model yeast cells and A549 lung cancer cell. This study demonstrates the potential of these species based on long-chain polyamines to serve as novel gene delivery systems.

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references

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