The Physical Chemistry for the Self-assembly of Peptide Hydrogels

Ying Li; Yi Cao

doi:10.1007/s10118-018-2099-6

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The Physical Chemistry for the Self-assembly of Peptide Hydrogels

REVIEWS | Updated：2021-02-18

- The Physical Chemistry for the Self-assembly of Peptide Hydrogels
- The Physical Chemistry for the Self-assembly of Peptide Hydrogels
- Chinese Journal of Polymer Science 2018年36卷第3期页码：366-378
- Affiliations：
  
  a.Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science and Engineering, Jiangsu Engineering Technology Research Centre of Environmental Cleaning Materials, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Jiangsu Joint Laboratory of Atmospheric Pollution Control, Nanjing University of Information Science & Technology, Nanjing 210044, China
  b.Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210093, China
- Author bio：
  
  Yi Cao, E-mail caoyi@nju.edu.cn
- Funds：
- DOI：10.1007/s10118-018-2099-6
  中图分类号：
- 收稿：2017-11-03，
  
  录用：2017-12-3，
  
  网络首发：2017-12-28，
  
  纸质出版：2018-03-05
- Accepted：
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Ying Li, Yi Cao. The Physical Chemistry for the Self-assembly of Peptide Hydrogels[J]. Chinese Journal of Polymer Science, 2018,36(3):366-378.

Ying Li, Yi Cao. The Physical Chemistry for the Self-assembly of Peptide Hydrogels[J]. Chinese Journal of Polymer Science, 2018, 36(3): 366-378.
Ying Li, Yi Cao. The Physical Chemistry for the Self-assembly of Peptide Hydrogels[J]. Chinese Journal of Polymer Science, 2018,36(3):366-378. DOI： 10.1007/s10118-018-2099-6.

Ying Li, Yi Cao. The Physical Chemistry for the Self-assembly of Peptide Hydrogels[J]. Chinese Journal of Polymer Science, 2018, 36(3): 366-378. DOI： 10.1007/s10118-018-2099-6.

摘要

Abstract

Peptide hydrogels have been widely used for diverse biomedical applications. However

our current understanding of the physical principles underlying the self-assembly process is still limited. In this review

we summarize our current understanding on the physical chemistry principles from the basic interactions that drive the self-assembly process to the energy landscapes that dictate the thermodynamics and kinetics of the process. We discuss the effect of different factors that affect the kinetics of the self-assembly of peptide fibrils and how this is related to the macroscopic gelation process. We provide our understanding on the molecular origin of the complex and rugged energy landscape for the self-assembly of peptide hydrogels. The hierarchical self-assembled structures and the diverse self-assembling mechanism make it difficult and challenging to rationally design the physical and chemical properties of peptide hydrogels at the molecular level. We also give our personal perspective to the potential future directions in this field.

关键词

Keywords

references

J. M. Lehn . Perspectives in supramolecular chemistry-from molecular recognition towards molecular informationprocessing and self-organization . Angew. Chem. Int. Ed. , 1990 . 29 ( 11 ): 1304 - 1319 . DOI: 10.1002/(ISSN)1521-3773 http://doi.org/10.1002/(ISSN)1521-3773 .

G. M. Whitesides , J. P. Mathias , C. T. Seto . Molecular self-assembly and nanochemistry-a chemical strategy for the synthesis of nanostructures . Science , 1991 . 254 ( 5036 ): 1312 - 1319 . http://www.sciencemag.org/content/254/5036/1312.short http://www.sciencemag.org/content/254/5036/1312.short , .

R. V. Ulijn , A. M. Smith . Designing peptide based nanomaterials . Chem. Soc. Rev. , 2008 . 37 ( 4 ): 664 - 675 . DOI: 10.1039/b609047h http://doi.org/10.1039/b609047h .

F. Zhao , M. L. Ma , B. Xu . Molecular hydrogels of therapeutic agents . Chem. Soc. Rev. , 2009 . 38 ( 4 ): 883 - 891 . DOI: 10.1039/b806410p http://doi.org/10.1039/b806410p .

H. Cui , M. J. Webber , S. I. Stupp . Self-assembly of peptide amphiphiles:from molecules to nanostructures to biomaterials . Biopolymers , 2010 . 94 ( 1 ): 1 - 18 . DOI: 10.1002/bip.21328 http://doi.org/10.1002/bip.21328 .

Y. Gao , Z. Yang , Y. Kuang , M. L. Ma , J. Li , F. Zhao , B. Xu . Enzyme-instructed self-assembly of peptide derivatives to form nanofibers and hydrogels . Biopolymers , 2010 . 94 ( 1 ): 19 - 31 . DOI: 10.1002/bip.21321 http://doi.org/10.1002/bip.21321 .

Y. Gao , F. Zhao , Q. Wang , Y. Zhang , B. Xu . Small peptide nanofibers as the matrices of molecular hydrogels for mimicking enzymes and enhancing the activity of enzymes . Chem. Soc. Rev. , 2010 . 39 ( 9 ): 3425 - 3433 . DOI: 10.1039/b919450a http://doi.org/10.1039/b919450a .

D. N. Woolfson . Building fibrous biomaterials from alpha-helical and collagen-like coiled-coil peptides . Biopolymers , 2010 . 94 ( 1 ): 118 - 127 . DOI: 10.1002/bip.21345 http://doi.org/10.1002/bip.21345 .

C. Yan , D. J. Pochan . Rheological properties of peptide-based hydrogels for biomedical and other applications . Chem. Soc. Rev. , 2010 . 39 ( 9 ): 3528 - 3540 . http://pubs.rsc.org/en/Content/ArticleLanding/CS/2010/B919449P http://pubs.rsc.org/en/Content/ArticleLanding/CS/2010/B919449P , .

T. Aida , E. W. Meijer , S. I. Stupp . Functional supramolecular polymers . Science , 2012 . 335 ( 6070 ): 813 - 817 . DOI: 10.1126/science.1205962 http://doi.org/10.1126/science.1205962 .

J. B. Matson , S. I. Stupp . Self-assembling peptide scaffolds for regenerative medicine . Chem. Commun. , 2012 . 48 ( 1 ): 26 - 33 . http://pubs.rsc.org/en/content/articlehtml/2012/cc/c1cc15551b http://pubs.rsc.org/en/content/articlehtml/2012/cc/c1cc15551b , .

J. Boekhoven , S. I. Stupp . 25th anniversary article:supramolecular materials for regenerative medicine . Adv. Mater. , 2014 . 26 ( 11 ): 1642 - 1659 . DOI: 10.1002/adma.201304606 http://doi.org/10.1002/adma.201304606 .

G. Fichman , E. Gazit . Self-assembly of short peptides to form hydrogels:design of building blocks, physical properties and technological applications . Acta Biomater. , 2014 . 10 ( 4 ): 1671 - 1682 . DOI: 10.1016/j.actbio.2013.08.013 http://doi.org/10.1016/j.actbio.2013.08.013 .

S. Fleming , R. V. Ulijn . Design of nanostructures based on aromatic peptide amphiphiles . Chem. Soc. Rev. , 2014 . 43 ( 23 ): 8150 - 8177 . DOI: 10.1039/C4CS00247D http://doi.org/10.1039/C4CS00247D .

V. W. Ng , J. M. Chan , H. Sardon , R. J. Ono , J. M. Garcia , Y. Y. Yang , J. L. Hedrick . Antimicrobial hydrogels:a new weapon in the arsenal against multidrug-resistant infections . Adv. Drug. Deliver. Rev. , 2014 . 78 46 - 62 . DOI: 10.1016/j.addr.2014.10.028 http://doi.org/10.1016/j.addr.2014.10.028 .

B. E. Ramakers , J. C. van Hest , D. W. Lowik . Molecular tools for the construction of peptide-based materials . Chem. Soc. Rev. , 2014 . 43 ( 8 ): 2743 - 2756 . DOI: 10.1039/c3cs60362h http://doi.org/10.1039/c3cs60362h .

C. Ren , J. Zhang , M. Chen , Z. Yang . Self-assembling small molecules for the detection of important analytes . Chem. Soc. Rev. , 2014 . 43 ( 21 ): 7257 - 7266 . DOI: 10.1039/C4CS00161C http://doi.org/10.1039/C4CS00161C .

X. Du , J. Zhou , J. Shi , B. Xu . Supramolecular hydrogelators and hydrogels:from soft matter to molecular biomaterials . Chem. Rev. , 2015 . 115 ( 24 ): 13165 - 13307 . http://pubs.acs.org/doi/pdfplus/10.1021/acs.chemrev.5b00299 http://pubs.acs.org/doi/pdfplus/10.1021/acs.chemrev.5b00299 , .

Y. Loo , C. A. Hauser . Bioprinting synthetic self-assembling peptide hydrogels for biomedical applications . Biomed. Mater. , 2015 . 11 ( 1 ): DOI: 10.1088/1748-6041/11/1/014103 http://doi.org/10.1088/1748-6041/11/1/014103 .

C. M. Rubert Perez , N. Stephanopoulos , S. Sur , S. S. Lee , C. Newcomb , S. I. Stupp . The powerful functions of peptide-based bioactive matrices for regenerative medicine . Ann. Biomed. Eng. , 2015 . 43 ( 3 ): 501 - 514 . https://link.springer.com/content/pdf/10.1007/s10439-014-1166-6.pdf https://link.springer.com/content/pdf/10.1007/s10439-014-1166-6.pdf , .

L. M. de Leon Rodriguez , Y. Hemar , J. Cornish , M. A. Brimble . Structure-mechanical property correlations of hydrogel forming beta-sheet peptides . Chem. Soc. Rev. , 2016 . 45 ( 17 ): 4797 - 4824 . DOI: 10.1039/C5CS00941C http://doi.org/10.1039/C5CS00941C .

S. Koutsopoulos . Self-assembling peptide nanofiber hydrogels in tissue engineering and regenerative medicine:progress, design guidelines, and applications . J. Biomed. Mater. Res. A , 2016 . 104 ( 4 ): 1002 - 1016 . https://trove.nla.gov.au/work/204500504 https://trove.nla.gov.au/work/204500504 , .

K. Tao , A. Levin , L. Adler-Abramovich , E. Gazit . Fmoc-modified amino acids and short peptides:simple bio-inspired building blocks for the fabrication of functional materials . Chem. Soc. Rev. , 2016 . 45 ( 14 ): 3935 - 3953 . DOI: 10.1039/C5CS00889A http://doi.org/10.1039/C5CS00889A .

X. Q. Dou , C. L. Feng . Amino acids and peptide-based supramolecular hydrogels for three-dimensional cell culture . Adv. Mater. , 2017 . 29 ( 16 ): DOI: 10.1002/adma.201604062 http://doi.org/10.1002/adma.201604062 .

S. Eskandari , T. Guerin , I. Toth , R. J. Stephenson . Recent advances in self-assembled peptides:Implications for targeted drug delivery and vaccine engineering . Adv. Drug. Deliver. Rev. , 2017 . 110 - 187 . 110-111, 169-187 https://espace.library.uq.edu.au/view/UQ:396332 https://espace.library.uq.edu.au/view/UQ:396332 , .

N. Singh , M. Kumar , J. F. Miravet , R. V. Ulijn , B. Escuder . Peptide-based molecular hydrogels as supramolecular protein mimics . Chemistry , 2017 . 23 ( 5 ): 981 - 993 . DOI: 10.1002/chem.201602624 http://doi.org/10.1002/chem.201602624 .

Z. Song , X. Chen , X. You , K. Huang , A. Dhinakar , Z. Gu , J. Wu . Self-assembly of peptide amphiphiles for drug delivery:the role of peptide primary and secondary structures . Biomater. Sci. , 2017 . 5 ( 12 ): 2369 - 2380 . DOI: 10.1039/C7BM00730B http://doi.org/10.1039/C7BM00730B .

P. Worthington , S. Langhans , D. Pochan . beta-hairpin peptide hydrogels for package delivery . Adv. Drug. Deliv. Rev. , 2017 . 110 - 136 . 110-111, 127-136 http://pubs.acs.org/doi/suppl/10.1021/ma5024796 http://pubs.acs.org/doi/suppl/10.1021/ma5024796 , .

J. Zhou , J. Li , X. Du , B. Xu . Supramolecular biofunctional materials . Biomaterials , 2017 . 129 1 - 27 . DOI: 10.1016/j.biomaterials.2017.03.014 http://doi.org/10.1016/j.biomaterials.2017.03.014 .

X. Zhao , F. Pan , H. Xu , M. Yaseen , H. Shan , C. A. Hauser , S. Zhang , J. R. Lu . Molecular self-assembly and applications of designer peptide amphiphiles . Chem. Soc. Rev. , 2010 . 39 ( 9 ): 3480 - 3498 . DOI: 10.1039/b915923c http://doi.org/10.1039/b915923c .

Z. Luo , S. Zhang . Designer nanomaterials using chiral self-assembling peptide systems and their emerging benefit for society . Chem. Soc. Rev. , 2012 . 41 ( 13 ): 4736 - 4754 . http://pubmed.cn/22627925 http://pubmed.cn/22627925 , .

C. J. Bowerman , B. L. Nilsson . Self-assembly of amphipathic beta-sheet peptides:insights and applications . Biopolymers , 2012 . 98 ( 3 ): 169 - 184 . DOI: 10.1002/bip.22058 http://doi.org/10.1002/bip.22058 .

E. R. Draper , D. J. Adams . Low-molecular-weight gels:the state of the art . Chem , 2017 . 3 ( 3 ): 390 - 410 . .

J. H. van Esch . We can design molecular gelators, but do we understand them? . Langmuir , 2009 . 25 ( 15 ): 8392 - 8394 . DOI: 10.1021/la901720a http://doi.org/10.1021/la901720a .

J. N. Onuchic , Z. Luthey-Schulten , P. G. Wolynes . Theory of protein folding:the energy landscape perspective . Annu. Rev. Phys. Chem. , 1997 . 48 545 - 600 . https://www.researchgate.net/profile/Peter_Wolynes/publication/13879984_Theory_of_Protein_Folding_The_Energy_Landscape_Perspective/links/548f51520cf225bf66a7ffc2.pdf https://www.researchgate.net/profile/Peter_Wolynes/publication/13879984_Theory_of_Protein_Folding_The_Energy_Landscape_Perspective/links/548f51520cf225bf66a7ffc2.pdf , .

Y. Li , M. Qin , Y. Cao , W. Wang . Designing the mechanical properties of peptide-based supramolecular hydrogels for biomedical applications . Sci. China Phys. Mech. , 2014 . 57 ( 5 ): 849 - 858 . DOI: 10.1007/s11433-014-5427-z http://doi.org/10.1007/s11433-014-5427-z .

J. Raeburn , A. Zamith Cardoso , D. J. Adams . The importance of the self-assembly process to control mechanical properties of low molecular weight hydrogels . Chem. Soc. Rev. , 2013 . 42 ( 12 ): 5143 - 5156 . DOI: 10.1039/c3cs60030k http://doi.org/10.1039/c3cs60030k .

E. Mattia , S. Otto . Supramolecular systems chemistry . Nat. Nanotechnol. , 2015 . 10 ( 2 ): 111 - 119 . DOI: 10.1038/nnano.2014.337 http://doi.org/10.1038/nnano.2014.337 .

S. Q. Cai , Z. G. Suo . Equations of state for ideal elastomeric gels . EPL , 2012 . 97 ( 3 ): DOI: 10.1209/0295-5075/97/34009 http://doi.org/10.1209/0295-5075/97/34009 .

W. R. K. Illeperuma , J. Y. Sun , Z. G. Suo , J. J. Vlassak . Force and stroke of a hydrogel actuator . Soft Matter , 2013 . 9 ( 35 ): 8504 - 8511 . DOI: 10.1039/c3sm51617b http://doi.org/10.1039/c3sm51617b .

J. D. Hartgerink , E. Beniash , S. I. Stupp . Self-assembly and mineralization of peptide-amphiphile nanofibers . Science , 2001 . 294 ( 5547 ): 1684 - 1688 . DOI: 10.1126/science.1063187 http://doi.org/10.1126/science.1063187 .

K. J. van Bommel , C. van der Pol , I. Muizebelt , A. Friggeri , A. Heeres , A. Meetsma , B. L. Feringa , J. van Esch . Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture . Angew. Chem. Int. Ed. , 2004 . 43 ( 13 ): 1663 - 1667 . DOI: 10.1002/(ISSN)1521-3773 http://doi.org/10.1002/(ISSN)1521-3773 .

H. Yokoi , T. Kinoshita , S. Zhang . Dynamic reassembly of peptide RADA16 nanofiber scaffold . Proc. Natl. Acad. Sci. USA , 2005 . 102 ( 24 ): 8414 - 8419 . DOI: 10.1073/pnas.0407843102 http://doi.org/10.1073/pnas.0407843102 .

J. P. Schneider , D. J. Pochan , B. Ozbas , K. Rajagopal , L. Pakstis , J. Kretsinger . Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide . J. Am. Chem. Soc. , 2002 . 124 ( 50 ): 15030 - 15037 . https://www.ncnr.nist.gov/programs/sans/pdf/publications/0262.pdf https://www.ncnr.nist.gov/programs/sans/pdf/publications/0262.pdf , .

A. M. Smith , R. J. Williams , C. Tang , P. Coppo , R. F. Collins , M. L. Turner , A. Saiani , R. V. Ulijn . Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on pi-pi interlocked beta-sheets . Adv. Mater. , 2008 . 20 ( 1 ): 37 - 41 . DOI: 10.1002/(ISSN)1521-4095 http://doi.org/10.1002/(ISSN)1521-4095 .

A. Mahler , M. Reches , M. Rechter , S. Cohen , E. Gazit . Rigid, self-assembled hydrogel composed of a modified aromatic dipeptide . Adv. Mater. , 2006 . 18 ( 11 ): 1365 - 1370 . DOI: 10.1002/(ISSN)1521-4095 http://doi.org/10.1002/(ISSN)1521-4095 .

M. Ma , Y. Kuang , Y. Gao , Y. Zhang , P. Gao , B. Xu . Aromatic-aromatic interactions induce the self-assembly of pentapeptidic derivatives in water to form nanofibers and supramolecular hydrogels . J. Am. Chem. Soc. , 2010 . 132 ( 8 ): 2719 - 2728 . DOI: 10.1021/ja9088764 http://doi.org/10.1021/ja9088764 .

D. A. Dougherty . The cation-pi interaction . Acc. Chem. Res. , 2013 . 46 ( 4 ): 885 - 893 . DOI: 10.1021/ar300265y http://doi.org/10.1021/ar300265y .

D. Chandler . Interfaces and the driving force of hydrophobic assembly . Nature , 2005 . 437 ( 7059 ): 640 - 647 . DOI: 10.1038/nature04162 http://doi.org/10.1038/nature04162 .

S. Tsonchev , K. L. Niece , G. C. Schatz , M. A. Ratner , S. I. Stupp . Phase diagram for assembly of biologically-active peptide amphiphiles . J. Phys. Chem. B , 2008 . 112 ( 2 ): 441 - 447 . DOI: 10.1021/jp076273z http://doi.org/10.1021/jp076273z .

T. H. Rehm , C. Schmuck . Ion-pair induced self-assembly in aqueous solvents . Chem. Soc. Rev. , 2010 . 39 ( 10 ): 3597 - 3611 . DOI: 10.1039/b926223g http://doi.org/10.1039/b926223g .

A. C. Legon , D. J. Millen . Angular geometries and other properties of hydrogen-bonded dimers-a simple electrostatic interpretation of the success of the electron-pair model . Chem. Soc. Rev. , 1987 . 16 ( 4 ): 467 - 498 . http://chem.scichina.com:8081/sciBe/CN/10.1007/s11426-011-4380-1 http://chem.scichina.com:8081/sciBe/CN/10.1007/s11426-011-4380-1 , .

T. P. Knowles , A. W. Fitzpatrick , S. Meehan , H. R. Mott , M. Vendruscolo , C. M. Dobson , M. E. Welland . Role of intermolecular forces in defining material properties of protein nanofibrils . Science , 2007 . 318 ( 5858 ): 1900 - 1903 . DOI: 10.1126/science.1150057 http://doi.org/10.1126/science.1150057 .

C. A. Hunter , J. K. M. Sanders . The nature of pi-pi interactions . J. Am. Chem. Soc. , 1990 . 112 ( 14 ): 5525 - 5534 . DOI: 10.1021/ja00170a016 http://doi.org/10.1021/ja00170a016 .

C. D. Ma , C. Wang , C. Acevedo-Velez , S. H. Gellman , N. L. Abbott . Modulation of hydrophobic interactions by proximally immobilized ions . Nature , 2015 . 517 ( 7534 ): 347 - 350 . https://www.chem.wisc.edu/content/modulation-hydrophobic-interactions-proximally-immobilized-ions https://www.chem.wisc.edu/content/modulation-hydrophobic-interactions-proximally-immobilized-ions , .

X. Yan , P. Zhu , J. Li . Self-assembly and application of diphenylalanine-based nanostructures . Chem. Soc. Rev. , 2010 . 39 ( 6 ): 1877 - 1890 . DOI: 10.1039/b915765b http://doi.org/10.1039/b915765b .

G. I. Bell . Models for specific adhesion of cells to cells . Science , 1978 . 200 ( 4342 ): 618 - 627 . DOI: 10.1126/science.347575 http://doi.org/10.1126/science.347575 .

M. Jaremko , L. Jaremko , H. Y. Kim , M. K. Cho , C. D. Schwieters , K. Giller , S. Becker , M. Zweckstetter . Cold denaturation of a protein dimer monitored at atomic resolution . Nat. Chem. Biol. , 2013 . 9 ( 4 ): 264 - 270 . DOI: 10.1038/nchembio.1181 http://doi.org/10.1038/nchembio.1181 .

J. M. Mason , K. M. Arndt . Coiled coil domains:stability, specificity, and biological implications . ChemBioChem , 2004 . 5 ( 2 ): 170 - 176 . http://cat.inist.fr/?aModele=afficheN&cpsidt=15460260 http://cat.inist.fr/?aModele=afficheN&cpsidt=15460260 , .

M. J. Pandya , G. M. Spooner , M. Sunde , J. R. Thorpe , A. Rodger , D. N. Woolfson . Sticky-end assembly of a designed peptide fiber provides insight into protein fibrillogenesis . Biochemistry , 2000 . 39 ( 30 ): 8728 - 8734 . DOI: 10.1021/bi000246g http://doi.org/10.1021/bi000246g .

E. F. Banwell , E. S. Abelardo , D. J. Adams , M. A. Birchall , A. Corrigan , A. M. Donald , M. Kirkland , L. C. Serpell , M. F. Butler , D. N. Woolfson . Rational design and application of responsive alpha-helical peptide hydrogels . Nat. Mater. , 2009 . 8 ( 7 ): 596 - 600 . DOI: 10.1038/nmat2479 http://doi.org/10.1038/nmat2479 .

C. Vepari , D. L. Kaplan . Silk as a Biomaterial . Prog. Polym. Sci. , 2007 . 32 ( 8-9 ): 991 - 1007 . https://www.sciencedirect.com/science/article/pii/S0079670007000731 https://www.sciencedirect.com/science/article/pii/S0079670007000731 , .

T. Asakura , T. Ohata , S. Kametani , K. Okushita , K. Yazawa , Y. Nishiyama , K. Nishimura , A. Aoki , F. Suzuki , H. Kaji , A. S. Ulrich , M. P. Williamson . Intermolecular packing in B. mori Silk fibroin:multinuclear NMR Study of the model peptide (Ala-Gly)(15) Defines a heterogeneous antiparallel antipolar mode of assembly in the silk ò form . Macromolecules , 2015 . 48 ( 1 ): 28 - 36 . DOI: 10.1021/ma502191g http://doi.org/10.1021/ma502191g .

G. H. Altman , F. Diaz , C. Jakuba , T. Calabro , R. L. Horan , J. S. Chen , H. Lu , J. Richmond , D. L. Kaplan . Silk-based biomaterials . Biomaterials. , 2003 . 24 ( 3 ): 401 - 416 . DOI: 10.1016/S0142-9612(02)00353-8 http://doi.org/10.1016/S0142-9612(02)00353-8 .

S. Zhang , T. Holmes , C. Lockshin , A. Rich . Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane . Proc. Natl. Acad. Sci. USA. , 1993 . 90 ( 8 ): 3334 - 3338 . DOI: 10.1073/pnas.90.8.3334 http://doi.org/10.1073/pnas.90.8.3334 .

J. H. Collier , B. H. Hu , J. W. Ruberti , J. Zhang , P. Shum , D. H. Thompson , P. B. Messersmith . Thermally and photochemically triggered self-assembly of peptide hydrogels . J. Am. Chem. Soc. , 2001 . 123 ( 38 ): 9463 - 9464 . DOI: 10.1021/ja011535a http://doi.org/10.1021/ja011535a .

C. J. Bowerman , W. Liyanage , A. J. Federation , B. L. Nilsson . Tuning beta-sheet peptide self-assembly and hydrogelation behavior by modification of sequence hydrophobicity and aromaticity . Biomacromolecules , 2011 . 12 ( 7 ): 2735 - 2745 . https://www.ncbi.nlm.nih.gov/pubmed/21568346 https://www.ncbi.nlm.nih.gov/pubmed/21568346 , .

N. R. Lee , C. J. Bowerman , B. L. Nilsson . Effects of varied sequence pattern on the self-assembly of amphipathic peptides . Biomacromolecules. , 2013 . 14 ( 9 ): 3267 - 3277 . DOI: 10.1021/bm400876s http://doi.org/10.1021/bm400876s .

H. Dong , S. E. Paramonov , L. Aulisa , E. L. Bakota , J. D. Hartgerink . Self-assembly of multidomain peptides:balancing molecular frustration controls conformation and nanostructure . J. Am. Chem. Soc. , 2007 . 129 ( 41 ): 12468 - 12472 . DOI: 10.1021/ja072536r http://doi.org/10.1021/ja072536r .

Z. M. Yang , K. M. Xu , Z. F. Guo , Z. H. Guo , B. Xu . Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death . Adv. Mater. , 2007 . 19 ( 20 ): 3152 - 3156 . DOI: 10.1002/adma.200701971 http://doi.org/10.1002/adma.200701971 .

Z. M. Yang , P. L. Ho , G. L. Liang , K. H. Chow , Q. G. Wang , Y. Cao , Z. H. Guo , B. Xu . Using beta-lactamase to trigger supramolecular hydrogelation . J. Am. Chem. Soc. , 2007 . 129 ( 2 ): 266 - 267 . DOI: 10.1021/ja0675604 http://doi.org/10.1021/ja0675604 .

Y. Zhang , Y. Kuang , Y. Gao , B. Xu . Versatile small-molecule motifs for self-assembly in water and the formation of biofunctional supramolecular hydrogels . Langmuir , 2011 . 27 ( 2 ): 529 - 537 . DOI: 10.1021/la1020324 http://doi.org/10.1021/la1020324 .

H. M. Wang , C. H. Yang , M. Tan , L. Wang , D. L. Kong , Z. M. Yang . A structure-gelation ability study in a short peptide-based nSuper Hydrogelatoro system . Soft Matter , 2011 . 7 ( 8 ): 3897 - 3905 . DOI: 10.1039/c0sm01405b http://doi.org/10.1039/c0sm01405b .

C. H. Liang , D. B. Zheng , F. Shi , T. Y. Xu , C. H. Yang , J. F. Liu , L. Wang , Z. M. Yang . Enzyme-assisted peptide folding, assembly and anti-cancer properties . Nanoscale , 2017 . 9 ( 33 ): 11987 - 11993 . DOI: 10.1039/C7NR04370H http://doi.org/10.1039/C7NR04370H .

Z. Y. Wang , C. H. Liang , F. Shi , T. He , C. Y. Gong , L. Wang , Z. M. Yang . Cancer vaccines using supramolecular hydrogels of NSAID-modified peptides as adjuvants abolish tumorigenesis . Nanoscale , 2017 . 9 ( 37 ): 14058 - 14064 . DOI: 10.1039/C7NR04990K http://doi.org/10.1039/C7NR04990K .

J. Zhan , Y. B. Cai , S. L. Ji , S. S. He , Y. Cao , D. Ding , L. Wang , Z. M. Yang . Spatiotemporal control of supramolecular self-assembly and function . ACS Appl. Mater. Interfaces , 2017 . 9 ( 11 ): 10012 - 10018 . http://pubsdc3.acs.org/doi/abs/10.1021/acsami.7b00784 http://pubsdc3.acs.org/doi/abs/10.1021/acsami.7b00784 , .

Y. B. Cai , H. S. Shen , J. Zhan , M. L. Lin , L. H. Dai , C. H. Ren , Y. Shi , J. F. Liu , J. Gao , Z. M. Yang . Supramolecular "Trojan Horse" for nuclear delivery of dual anticancer drugs . J. Am. Chem. Soc. , 2017 . 139 ( 8 ): 2876 - 2879 . DOI: 10.1021/jacs.6b12322 http://doi.org/10.1021/jacs.6b12322 .

H. M. Wang , Z. Luo , Y. C. Z. Wang , T. He , C. B. Yang , C. H. Ren , L. S. Ma , C. Y. Gong , X. Y. Li , Z. M. Yang . Enzyme-catalyzed formation of supramolecular hydrogels as promising vaccine adjuvants . Adv. Funct. Mater. , 2016 . 26 ( 11 ): 1822 - 1829 . http://onlinelibrary.wiley.com/doi/10.1002/adfm.201505188/abstract http://onlinelibrary.wiley.com/doi/10.1002/adfm.201505188/abstract , .

X. L. Zhang , C. M. Dong , W. Y. Huang , H. M. Wang , L. Wang , D. Ding , H. Zhou , J. F. Long , T. L. Wang , Z. M. Yang . Rational design of a photo-responsive UVR8-derived protein and a self-assembling peptide-protein conjugate for responsive hydrogel formation . Nanoscale , 2015 . 7 ( 40 ): 16666 - 16670 . DOI: 10.1039/C5NR05213K http://doi.org/10.1039/C5NR05213K .

J. W. Zhang , C. W. Ou , Y. Shi , L. Wang , M. S. Chen , Z. M. Yang . Visualized detection of melamine in milk by supramolecular hydrogelations . Chem. Commun. , 2014 . 50 ( 85 ): 12873 - 12876 . DOI: 10.1039/C4CC05826G http://doi.org/10.1039/C4CC05826G .

Z. J. Hai , J. D. Li , J. J. Wu , J. C. Xu , G. L. Liang . Alkaline phosphatase-triggered simultaneous hydrogelation and chemiluminescence . J. Am. Chem. Soc. , 2017 . 139 ( 3 ): 1041 - 1044 . DOI: 10.1021/jacs.6b11041 http://doi.org/10.1021/jacs.6b11041 .

C. F. Wu , Z. Zheng , Y. N. Guo , C. L. Tian , Q. Xue , G. L. Liang . Fluorine substitution enhances the self-assembling ability of hydrogelators . Nanoscale , 2017 . 9 ( 32 ): 11429 - 11433 . http://onlinelibrary.wiley.com/doi/10.1002/1521-3773(20000703)39:13%3C2263::AID-ANIE2263%3E3.0.CO;2-V/abstract http://onlinelibrary.wiley.com/doi/10.1002/1521-3773(20000703)39:13%3C2263::AID-ANIE2263%3E3.0.CO;2-V/abstract , .

Z. Zheng , P. Y. Chen , M. L. Xie , C. F. Wu , Y. F. Luo , W. T. Wang , J. Jiang , G. L. Liang . Cell environment-differentiated self-assembly of nanofibers . J. Am. Chem. Soc. , 2016 . 138 ( 35 ): 11128 - 11131 . DOI: 10.1021/jacs.6b06903 http://doi.org/10.1021/jacs.6b06903 .

Y. Ding , Y. Li , M. Qin , Y. Cao , W. Wang . Photo-cross-linking approach to engineering small tyrosine-containing peptide hydrogels with enhanced mechanical stability . Langmuir , 2013 . 29 ( 43 ): 13299 - 13306 . DOI: 10.1021/la4029639 http://doi.org/10.1021/la4029639 .

B. Xue , M. Qin , T. K. Wang , J. H. Wu , D. J. Luo , Q. Jiang , Y. Li , Y. Cao , W. Wang . Electrically controllable actuators based on supramolecular peptide hydrogels . Adv. Funct. Mater. , 2016 . 26 ( 48 ): 9053 - 9062 . DOI: 10.1002/adfm.v26.48 http://doi.org/10.1002/adfm.v26.48 .

Y. Li , L. Wang . Removing organic dyes by using a small peptide hydrogel . Chem. Lett. , 2016 . 45 ( 11 ): 1253 - 1255 . DOI: 10.1246/cl.160597 http://doi.org/10.1246/cl.160597 .

W. Cheng , Y. Li . Peptide hydrogelation triggered by enzymatic induced pH switch . Sci. China Phys. Mech. , 2016 . 59 ( 7 ): 678 - 711 . http://adsabs.harvard.edu/abs/2016SCPMA..59g..83C http://adsabs.harvard.edu/abs/2016SCPMA..59g..83C , .

C. J. Newcomb , R. Bitton , Y. S. Velichko , M. L. Snead , S. I. Stupp . The role of nanoscale architecture in supramolecular templating of biomimetic hydroxyapatite mineralization . Small , 2012 . 8 ( 14 ): 2195 - 2202 . http://onlinelibrary.wiley.com/doi/10.1002/smll.201102150/full http://onlinelibrary.wiley.com/doi/10.1002/smll.201102150/full , .

E. T. Pashuck , H. G. Cui , S. I. Stupp . Tuning supramolecular rigidity of peptide fibers through molecular structure . J. Am. Chem. Soc. , 2010 . 132 ( 17 ): 6041 - 6046 . DOI: 10.1021/ja908560n http://doi.org/10.1021/ja908560n .

R. M. da Silva , D. van der Zwaag , L. Albertazzi , S. S. Lee , E. W. Meijer , S. I. Stupp . Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres . Nat. Commun. , 2016 . 7 DOI: 10.1038/ncomms11561 http://doi.org/10.1038/ncomms11561 .

J. H. Ortony , B. Qiao , C. J. Newcomb , T. J. Keller , L. C. Palmer , E. Deiss-Yehiely , M. Olvera de la Cruz , S. Han , S. I. Stupp . Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure . J. Am. Chem. Soc. , 2017 . 139 ( 26 ): 8915 - 8921 . DOI: 10.1021/jacs.7b02969 http://doi.org/10.1021/jacs.7b02969 .

D. J. Pochan , J. P. Schneider , J. Kretsinger , B. Ozbas , K. Rajagopal , L. Haines . Thermally reversible hydrogels via intramolecular folding and consequent self-assembly of a de novo designed peptide . J. Am. Chem. Soc. , 2003 . 125 ( 39 ): 11802 - 11803 . DOI: 10.1021/ja0353154 http://doi.org/10.1021/ja0353154 .

M. S. Lamm , K. Rajagopal , J. P. Schneider , D. J. Pochan . Laminated morphology of nontwisting beta-sheet fibrils constructed via peptide self-assembly . J. Am. Chem. Soc. , 2005 . 127 ( 47 ): 16692 - 16700 . http://pubs.acs.org/doi/pdf/10.1021/ja054721f?cookieSet=1 http://pubs.acs.org/doi/pdf/10.1021/ja054721f?cookieSet=1 , .

D. A. Salick , D. J. Pochan , J. P. Schneider . Design of an injectable beta-hairpin peptide hydrogel that kills methicillin-resistant staphylococcus aureus . Adv. Mater. , 2009 . 21 ( 41 ): 4120 - 4123 . http://doi.wiley.com/10.1002/adma.200900189 http://doi.wiley.com/10.1002/adma.200900189 , .

R. V. Rughani , D. A. Salick , M. S. Lamm , T. Yucel , D. J. Pochan , J.P. Schneider . Folding, self-assembly, and bulk material properties of a de novo designed three-stranded beta-sheet hydrogel . Biomacromolecules , 2009 . 10 ( 5 ): 1295 - 1304 . DOI: 10.1021/bm900113z http://doi.org/10.1021/bm900113z .

K. Rajagopal , M. S. Lamm , L. A. Haines-Butterick , D. J. Pochan , J. P. Schneider . Tuning the pH Responsiveness of beta-Hairpin peptide folding, self-assembly, and hydrogel material formation . Biomacromolecules , 2009 . 10 ( 9 ): 2619 - 2625 . DOI: 10.1021/bm900544e http://doi.org/10.1021/bm900544e .

B. Y. Ding , Y. Li , M. Qin , Y. Ding , Y. Cao , W. Wang . Two approaches for the engineering of homogeneous small-molecule hydrogels . Soft Matter , 2013 . 9 ( 18 ): 4672 - 4680 . DOI: 10.1039/c3sm50324k http://doi.org/10.1039/c3sm50324k .

J. Wang , K. Liu , R. Xing , X. Yan . Peptide self-assembly:thermodynamics and kinetics . Chem. Soc. Rev. , 2016 . 45 ( 20 ): 5589 - 5604 . DOI: 10.1039/C6CS00176A http://doi.org/10.1039/C6CS00176A .

I. R. Sasselli , P. J. Halling , R. V. Ulijn , T. Tuttle . Supramolecular fibers in gels can be at thermodynamic equilibrium:a simple packing model reveals preferential fibril formation versus crystallization . ACS Nano , 2016 . 10 ( 2 ): 2661 - 2668 . DOI: 10.1021/acsnano.5b07690 http://doi.org/10.1021/acsnano.5b07690 .

D. J. Adams , K. Morris , L. Chen , L. C. Serpell , J. Bacsa , G. M. Day . The delicate balance between gelation and crystallisation:structural and computational investigations . Soft Matter , 2010 . 6 ( 17 ): 4144 - 4156 . DOI: 10.1039/c0sm00409j http://doi.org/10.1039/c0sm00409j .

Y. Lan , M. G. Corradini , R. G. Weiss , S. R. Raghavan , M. A. Rogers . To gel or not to gel:correlating molecular gelation with solvent parameters . Chem. Soc. Rev. , 2015 . 44 ( 17 ): 6035 - 6058 . DOI: 10.1039/C5CS00136F http://doi.org/10.1039/C5CS00136F .

M. Raynal , L. Bouteiller . Organogel formation rationalized by Hansen solubility parameters . Chem. Commun. , 2011 . 47 ( 29 ): 8271 - 8273 . DOI: 10.1039/c1cc13244j http://doi.org/10.1039/c1cc13244j .

G. O. Lloyd , J. W. Steed . Anion-tuning of supramolecular gel properties . Nat. Chem. , 2009 . 1 ( 6 ): 437 - 442 . DOI: 10.1038/nchem.283 http://doi.org/10.1038/nchem.283 .

F. Massi , J. E. Straub . Energy landscape theory for Alzheimer's amyloid beta-peptide fibril elongation . Proteins , 2001 . 42 ( 2 ): 217 - 229 . http://onlinelibrary.wiley.com/doi/10.1002/1097-0134(20010201)42:2%3C217::AID-PROT90%3E3.0.CO;2-N/full http://onlinelibrary.wiley.com/doi/10.1002/1097-0134(20010201)42:2%3C217::AID-PROT90%3E3.0.CO;2-N/full , .

J. E. Straub , D. Thirumalai . Toward a molecular theory of early and late events in monomer to amyloid fibril formation . Annu. Rev. Phys. Chem. , 2011 . 62 437 - 463 . DOI: 10.1146/annurev-physchem-032210-103526 http://doi.org/10.1146/annurev-physchem-032210-103526 .

P. T. Lansbury . A reductionist view of Alzheimer's disease . Acc. Chem. Res. , 1996 . 29 ( 7 ): 317 - 321 . DOI: 10.1021/ar950159u http://doi.org/10.1021/ar950159u .

D. Hall , N. Hirota , C. M. Dobson . A toy model for predicting the rate of amyloid formation from unfolded protein . J. Mol. Biol. , 2005 . 351 ( 1 ): 195 - 205 . DOI: 10.1016/j.jmb.2005.05.013 http://doi.org/10.1016/j.jmb.2005.05.013 .

A. Lomakin , D. S. Chung , G. B. Benedek , D. A. Kirschner , D. B. Teplow . On the nucleation and growth of amyloid beta-protein fibrils:detection of nuclei and quantitation of rate constants . Proc. Natl. Acad. Sci. USA , 1996 . 93 ( 3 ): 1125 - 1129 . DOI: 10.1073/pnas.93.3.1125 http://doi.org/10.1073/pnas.93.3.1125 .

A. Lomakin , D. B. Teplow , D. A. Kirschner , G. B. Benedek . Kinetic theory of fibrillogenesis of amyloid beta-protein . Proc. Natl. Acad. Sci. USA. , 1997 . 94 ( 15 ): 7942 - 7947 . DOI: 10.1073/pnas.94.15.7942 http://doi.org/10.1073/pnas.94.15.7942 .

T. J. Gibson , R. M. Murphy . Design of peptidyl compounds that affect beta-amyloid aggregation:importance of surface tension and context . Biochemistry , 2005 . 44 ( 24 ): 8898 - 8907 . DOI: 10.1021/bi050225s http://doi.org/10.1021/bi050225s .

T. P. Knowles , C. A. Waudby , G. L. Devlin , S. I. Cohen , A. Aguzzi , M. Vendruscolo , E. M. Terentjev , M. E. Welland , C. M. Dobson . An analytical solution to the kinetics of breakable filament assembly . Science , 2009 . 326 ( 5959 ): 1533 - 1537 . DOI: 10.1126/science.1178250 http://doi.org/10.1126/science.1178250 .

J. D. Harper , S. S. Wong , C. M. Lieber , P. T. Lansbury . Observation of metastable Abeta amyloid protofibrils by atomic force microscopy . Chem. Biol. , 1997 . 4 ( 2 ): 119 - 125 . DOI: 10.1016/S1074-5521(97)90255-6 http://doi.org/10.1016/S1074-5521(97)90255-6 .

D. M. Walsh , A. Lomakin , G. B. Benedek , M. M. Condron , D. B. Teplow . Amyloid beta-protein fibrillogenesis . Detection of a protofibrillar intermediate. J. Biol. Chem. , 1997 . 272 ( 35 ): 22364 - 22372 . http://www.jbc.org/cgi/doi/10.1074/jbc.274.36.25945 http://www.jbc.org/cgi/doi/10.1074/jbc.274.36.25945 , .

P. Arosio , T. P. J. Knowles , S. Linse . On the lag phase in amyloid fibril formation . Phys. Chem. Chem. Phys. , 2015 . 17 ( 12 ): 7606 - 7618 . DOI: 10.1039/C4CP05563B http://doi.org/10.1039/C4CP05563B .

N. L. Fletcher , C. V. Lockett , A. F. Dexter . A pH-responsive coiled-coil peptide hydrogel . Soft Matter , 2011 . 7 ( 21 ): 10210 - 10218 . http://pubs.rsc.org/en/Content/ArticleLanding/SM/2011/C1SM06261A#!divAbstract http://pubs.rsc.org/en/Content/ArticleLanding/SM/2011/C1SM06261A#!divAbstract , .

F. Massi , J. E. Straub . Energy landscape theory for Alzheimer's amyloid beta-peptide fibril elongation . Proteins , 2001 . 42 ( 2 ): 217 - 229 . DOI: 10.1002/(ISSN)1097-0134 http://doi.org/10.1002/(ISSN)1097-0134 .

S. Ahmed , B. Pramanik , K. N. A. Sankar , A. Srivastava , N. Singha , P. Dowari , A. Srivastava , K. Mohanta , A. Debnath , D. Das . Solvent assisted tuning of morphology of a peptide-perylenediimide conjugate: helical fibers to nano-rings and their differential semiconductivity . Sci. Rep. , 2017 . 7 ( 1 ): DOI: 10.1038/s41598-017-09730-z http://doi.org/10.1038/s41598-017-09730-z .

Y. Tian , H. V. Zhang , K. L. Kiick , J. G. Saven , D. J. Pochan . Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide . Org. Biomol. Chem. , 2017 . 15 ( 29 ): 6109 - 6118 . DOI: 10.1039/C7OB01197K http://doi.org/10.1039/C7OB01197K .

Y. Wang , R. Huang , W. Qi , Z. Wu , R. Su , Z. He . Kinetically controlled self-assembly of redox-active ferrocene-diphenylalanine: from nanospheres to nanofibers . Nanotechnology , 2013 . DOI: 10.1088/0957-4484/24/46/465603 http://doi.org/10.1088/0957-4484/24/46/465603 .

T. Heuser , E. Weyandt , A. Walther . Biocatalytic feedback-driven temporal programming of self-regulating peptide hydrogels . Angew. Chem. Int. Ed. , 2015 . 54 ( 45 ): 13258 - 13262 . DOI: 10.1002/anie.201505013 http://doi.org/10.1002/anie.201505013 .

M. P. Conte , N. Singh , I. R. Sasselli , B. Escuder , R. V. Ulijn . Metastable hydrogels from aromatic dipeptides . Chem. Commun. , 2016 . 52 ( 96 ): 13889 - 13892 . http://www.rsc.org/suppdata/c6/cc/c6cc05821c/c6cc05821c1.pdf http://www.rsc.org/suppdata/c6/cc/c6cc05821c/c6cc05821c1.pdf , .

S. Debnath , S. Roy , R. V. Ulijn . Peptide nanofibers with dynamic instability through nonequilibrium biocatalytic assembly . J. Am. Chem. Soc. , 2013 . 135 ( 45 ): 16789 - 16792 . DOI: 10.1021/ja4086353 http://doi.org/10.1021/ja4086353 .

R. J. Williams , A. M. Smith , R. Collins , N. Hodson , A. K. Das , R. V. Ulijn . Enzyme-assisted self-assembly under thermodynamic control . Nat. Nanotechnol. , 2009 . 4 ( 1 ): 19 - 24 . DOI: 10.1038/nnano.2008.378 http://doi.org/10.1038/nnano.2008.378 .

D. J. Adams , M. F. Butler , W. J. Frith , M. Kirkland , L. Mullen , P. Sanderson . A new method for maintaining homogeneity during liquid-hydrogel transitions using low molecular weight hydrogelators . Soft Matter , 2009 . 5 ( 9 ): 1856 - 1862 . DOI: 10.1039/b901556f http://doi.org/10.1039/b901556f .

D. U. Ferreiro , E. A. Komives , P. G. Wolynes . Frustration in biomolecules . Q. Rev. Biophys. , 2014 . 47 ( 4 ): 285 - 363 . DOI: 10.1017/S0033583514000092 http://doi.org/10.1017/S0033583514000092 .

P.G. Wolynes . Evolution, energy landscapes and the paradoxes of protein folding . Biochimie. , 2015 . 119 218 - 230 . DOI: 10.1016/j.biochi.2014.12.007 http://doi.org/10.1016/j.biochi.2014.12.007 .

Y. Levy , J. N. Onuchic . Mechanisms of protein assembly: lessons from minimalist models . Acc. Chem. Res. , 2006 . 39 ( 2 ): 135 - 142 . DOI: 10.1021/ar040204a http://doi.org/10.1021/ar040204a .

M. Friedel , J. E. Shea . Self-assembly of peptides into a beta-barrel motif . J. Chem. Phys. , 2004 . 120 ( 12 ): 5809 - 5823 . DOI: 10.1063/1.1649934 http://doi.org/10.1063/1.1649934 .

M. Schmidt , A. Rohou , K. Lasker , J. K. Yadav , C. Schiene-Fischer , M. Fandrich , N. Grigorieff . Peptide dimer structure in an Abeta(1-42) fibril visualized with cryo-EM . Proc. Natl. Acad. Sci. USA , 2015 . 112 ( 38 ): 11858 - 11863 . DOI: 10.1073/pnas.1503455112 http://doi.org/10.1073/pnas.1503455112 .

D. Pinotsi , G. S. Kaminski Schierle , C. F. Kaminski . Optical Super-resolution imaging of beta-amyloid aggregation in vitro and in vivo: method and techniques . Method. Mol. Biol. , 2016 . 1303 125 - 141 . http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-4939-2627-5_6 http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-4939-2627-5_6 , .

P. E. Milhiet , D. Yamamoto , O. Berthoumieu , P. Dosset , C. Le Grimellec , J. M. Verdier , S. Marchal , T. Ando . Deciphering the structure, growth and assembly of amyloid-like fibrils using high-speed atomic force microscopy . PLoS One. , 2010 . 5 ( 10 ): DOI: 10.1371/journal.pone.0013240 http://doi.org/10.1371/journal.pone.0013240 .

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