Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications

Wen-Ming Zhang; Jian Zhang; Zhu Qiao; Jun Yin

doi:10.1007/s10118-018-2035-9

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Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications

FEATURE ARTICLES | Updated：2021-02-18

- Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications
- Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications
- Chinese Journal of Polymer Science 2018年36卷第3期页码：273-287
- Affiliations：
  
  Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, Hefei 230009, China
- Author bio：
  
  Jun Yin, E-mail yinjun@hfut.edu.cn
- Funds：
- DOI：10.1007/s10118-018-2035-9
  中图分类号：
- 收稿：2017-08-17，
  
  录用：2017-9-5，
  
  网络首发：2017-12-20，
  
  纸质出版：2018-03-05
- Accepted：
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Wen-Ming Zhang, Jian Zhang, Zhu Qiao, 等. Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications[J]. Chinese Journal of Polymer Science, 2018,36(3):273-287.

Wen-Ming Zhang, Jian Zhang, Zhu Qiao, et al. Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications[J]. Chinese Journal of Polymer Science, 2018, 36(3): 273-287.
Wen-Ming Zhang, Jian Zhang, Zhu Qiao, 等. Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications[J]. Chinese Journal of Polymer Science, 2018,36(3):273-287. DOI： 10.1007/s10118-018-2035-9.

Wen-Ming Zhang, Jian Zhang, Zhu Qiao, et al. Functionally Oriented Tumor Microenvironment Responsive Polymeric Nanoassembly: Engineering and Applications[J]. Chinese Journal of Polymer Science, 2018, 36(3): 273-287. DOI： 10.1007/s10118-018-2035-9.

摘要

Abstract

The excellent drug encapsulation

prolonged

in vivo

circulation time

enhanced pharmacokinetics

and reduced adverse effects make the polymeric assemblies ideal carriers in nanomedicine

and become an emerging research field with rapid development.

In vivo

the polymer nanoassemblies will experience five steps

including circulation in the blood

accumulation in the tumoral site

penetration into the deep tumor tissue to reach cancer cells

internalization into cancer cells

and intracellular drug release. However

although tremendous efforts have been made to the material design

currently available carriers still have difficulties in fulfilling all of the requirements. Moreover

the long-standing dilemma of the synchronized stability and permeability of vesicles is still a big challenge

which confused researchers for a long time. This feature article focuses on the recent progress of single-or multi-stimuli triggered theranostic platforms

and the extracellularly reengineered shell-sheddable polymeric nanocarriers are systematically discussed. The perspectives for future developments in the nanocarriers functioned with artificial helical polymers (the potential cell-penetrating peptides mimics) are also proposed. We speculate that this feature article can fit the interesting of diverse readers and a guideline for the design of next generation of drug nanocarriers.

关键词

Keywords

references

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