Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy

Dan-Hua Zhou; Guan Zhang; Qing-Song Yu; Zhi-Hua Gan

doi:10.1007/s10118-018-2009-y

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Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy

Articles | Updated：2021-02-18

- Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy
- Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy
- Chinese Journal of Polymer Science 2018年36卷第4期页码：479-487
- Affiliations：
  
  a.National University of Singapore Environmental Research Institute(NERI), National University of Singapore, Singapore 117576, Singapore
  b.Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-inorganic Composite Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  c.Department of Urology, China-Japan Friendship Hospital, Beijing 100029, China
- Author bio：
  
  E-mail yuqs@mail.buct.edu.cn (Q.S.Y)
  E-mail zhgan@mail.buct.edu.cn (Z.H.G)
- Funds：
- DOI：10.1007/s10118-018-2009-y
  中图分类号：
- 收稿：2017-06-28，
  
  录用：2017-7-12，
  
  网络首发：2018-12-20，
  
  纸质出版：2018-04-05
- Accepted：
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Dan-Hua Zhou, Guan Zhang, Qing-Song Yu, 等. Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy[J]. Chinese Journal of Polymer Science, 2018,36(4):479-487.

Dan-Hua Zhou, Guan Zhang, Qing-Song Yu, et al. Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy[J]. Chinese Journal of Polymer Science, 2018, 36(4): 479-487.
Dan-Hua Zhou, Guan Zhang, Qing-Song Yu, 等. Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy[J]. Chinese Journal of Polymer Science, 2018,36(4):479-487. DOI： 10.1007/s10118-018-2009-y.

Dan-Hua Zhou, Guan Zhang, Qing-Song Yu, et al. Folic Acid Modified Polymeric Micelles for Intravesical Instilled Chemotherapy[J]. Chinese Journal of Polymer Science, 2018, 36(4): 479-487. DOI： 10.1007/s10118-018-2009-y.

摘要

Abstract

In this study

a targeting micellar drug delivery system was developed for intravesical instilled chemotherapy of bladder cancer. The amphiphilic diblock copolymer poly(

-caprolactone)-block-poly(ethylene glycol) (PCL-

-PEO) with functional amino group (NH

) at the end of PEO block was synthesized. Then the copolymer was conjugated with folic acid (FA) and fluorescein isothiocyannate (FITC)

via

the PEO-NH

terminus

and then assembled into micelles with the target moiety and fluorescence labeling. In addition

drug loaded micelles were also fabricated with anticancer drug doxorubicin (DOX) encapsulated in the hydrophobic core. The micelles were characterized in terms of size

drug loaded efficiency and critical micellization concentration (CMC) by means of DLS

UV and fluorescence spectra.

In vitro

cellular uptake and cytotoxicity studies showed that FA modified PCL-

-PEO-FA micelles have a greater targeting efficiency to human bladder cancer cell (T-24 cell) compared to PCL-

-PEO-NH

micelles due to the conjugation of FA on the surface

while no targeting effect to normal tissue originated human embryonic kidney 293 (HEK-293) cells was observed

enabling the micelles a promising drug carrier for intravesical instilled chemotherapy of bladder cancer.

关键词

Keywords

references

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