CO<sub>2</sub>-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

Xian-Wu Jing; Zhi-Yu Huang; Hong-Sheng Lu; Bao-Gang Wang

doi:10.1007/s10118-018-2008-z

Your Location：

Home >

Browse articles >

CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

PAPERS | Updated：2021-02-18

- CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle
- CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle
- Chinese Journal of Polymer Science 2018年36卷第1期页码：18-24
- Affiliations：
  
  a.College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China
  b.Engineering Research Center of Oilfield Chemistry, Ministry of Education, Chengdu 610500, China
- Author bio：
  
  E-mail hzy3019@163.com (Z.Y.H.)
  E-mail hshlu@swpu.edu.cn (H.S.L.)
- Funds：
- DOI：10.1007/s10118-018-2008-z
  中图分类号：
- 收稿：2017-04-25，
  
  修回：2017-7-5，
  
  录用：2017-7-5，
  
  网络首发：2017-10-20，
  
  纸质出版：2018-01-05
- Accepted：
Scan QR Code
Xian-Wu Jing, Zhi-Yu Huang, Hong-Sheng Lu, 等. CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle[J]. Chinese Journal of Polymer Science, 2018,36(1):18-24. DOI: 10.1007/s10118-018-2008-z.

Xian-Wu Jing, Zhi-Yu Huang, Hong-Sheng Lu, et al. CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle[J]. Chinese Journal of Polymer Science, 2018, 36(1): 18-24. DOI: 10.1007/s10118-018-2008-z.
Xian-Wu Jing, Zhi-Yu Huang, Hong-Sheng Lu, 等. CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle[J]. Chinese Journal of Polymer Science, 2018,36(1):18-24. DOI: 10.1007/s10118-018-2008-z. DOI：

Xian-Wu Jing, Zhi-Yu Huang, Hong-Sheng Lu, et al. CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle[J]. Chinese Journal of Polymer Science, 2018, 36(1): 18-24. DOI: 10.1007/s10118-018-2008-z. DOI：

摘要

Abstract

A series of triblock copolymers

containing a CO

-switchable block poly(2-(dimethylamino)ethyl methacrylate) (PDM) block and two symmetrical hydrophilic blocks polyacrylamide (PAM)

were synthesized using atom transfer radical polymerization (ATRP) method. The pH and conductivity tests showed that the triblock copolymer exhibited switchable responsiveness to CO

i.e

. a relatively low conductivity of solution could be switched on and off by bubbling and removing of CO

and the triblock copolymer aqueous solution displayed a CO

-switchable viscosity variation. The changes were all attributed to protonation of tertiary amine groups in PDM blocks and proven by

H-NMR. Cryogenic transmission electron microscopy and dynamic light scattering characterization demonstrated that the viscosity variation was the result of a unilamellar vesicle-network aggregate structure transition. The release of rhodamine B from the vesicles with and without CO

stimuli showed the potential application in drug delivery domains; after CO

bubbling

the drug release rate could be accelerated. Finally

reasonable mechanism of CO

-switchable morphology changes and CO

-induced drug release was proposed.

关键词

Keywords

references

J. S. Wang , K. Matyjaszewski . Controlled/"living" radical polymerization. atom transfer radical polymerization in the presence of transition-metal complexes . J. Am. Chem. Soc. , 1995 . 117 ( 20 ): 127 - 134 . .

M. Kato , M. Kamigaito , M. Sawamoto , T. Higashimura . Polymerization of methyl methacrylate with the carbon tetrachloride/dichlorotris-(triphenylphosphine)ruthenium(Ⅱ)/methylaluminum bis(2, 6-di- tert -butylphenoxide) initiating system:possibility of living radical polymerization . Macromolecules , 1995 . 28 ( 5 ): 1721 - 1723 . DOI: 10.1021/ma00109a056 http://doi.org/10.1021/ma00109a056 .

Z. Gao , S. K. Varshney , S. Wong , A. Eisenberg . Block copolymer "crew-cut" micelles in water . Macromolecules , 1994 . 27 ( 26 ): 7923 - 7927 . DOI: 10.1021/ma00104a058 http://doi.org/10.1021/ma00104a058 .

J. Du , R. K. O'Reilly . Advances and challenges in smart and functional polymer vesicles . Soft Matter , 2009 . 5 ( 19 ): 3544 - 3561 . DOI: 10.1039/b905635a http://doi.org/10.1039/b905635a .

C. Fernyhough , A. J. Ryan , G. Battaglia . pH controlled assembly of a polybutadiene-poly(methacrylic acid) copolymer in water:packing considerations and kinetic limitations . Soft Matter , 2009 . 5 ( 8 ): 1674 - 1682 . DOI: 10.1039/b817218h http://doi.org/10.1039/b817218h .

N. J. Warren , O. O. Mykhaylyk , D. Mahmood , A. J. Ryan , S. P. Armes . RAFT aqueous dispersion polymerization yields poly(ethylene glycol)-based diblock copolymer nano-objects with predictable single phase morphologies . J. Am. Chem. Soc. , 2014 . 136 ( 3 ): 1023 - 1033 . DOI: 10.1021/ja410593n http://doi.org/10.1021/ja410593n .

A. H. Groschel , A. Walther , T. I. Lobling , J. Schmelz , A. Hanisch , H. Schmalz , A.H. E. Muller . Facile, solution-based synthesis of soft, nanoscale Janus particles with tunable Janus balance . J. Am. Chem. Soc. , 2012 . 134 ( 33 ): 13850 - 13860 . DOI: 10.1021/ja305903u http://doi.org/10.1021/ja305903u .

M. Li , G. L. Li , Z. Zhang , J. Li , K. G. Neoh , E. T. Kang . Self-assembly of pH-responsive and fluorescent comb-like amphiphilic copolymers in aqueous media . Polymer , 2010 . 51 ( 15 ): 3377 - 3386 . DOI: 10.1016/j.polymer.2010.05.032 http://doi.org/10.1016/j.polymer.2010.05.032 .

Y. Morishima . Thermally responsive polymer vesicles . Angew. Chem. Int. Ed. , 2007 . 46 ( 9 ): 1370 - 1372 . DOI: 10.1002/(ISSN)1521-3773 http://doi.org/10.1002/(ISSN)1521-3773 .

B. M. Discher , Y. Y. Won , D. S. Ege , J. C. Lee , F. S. Bates , D. E. Discher , D. A. Hammer . Polymersomes:tough vesicles made from diblock copolymers . Science , 1999 . 284 ( 5417 ): 1143 - 1146 . DOI: 10.1126/science.284.5417.1143 http://doi.org/10.1126/science.284.5417.1143 .

S. J. Byard , M. Williams , B. E. McKenzie , A. Blanazs , S. P. Armes . Preparation and cross-linking of all-acrylamide diblock copolymer nano-objects via polymerization-induced self-assembly in aqueous solution . Macromolecules , 2017 . 50 ( 4 ): 1482 - 1493 . DOI: 10.1021/acs.macromol.6b02643 http://doi.org/10.1021/acs.macromol.6b02643 .

J. Hu , S. Liu . Responsive polymers for detection and sensing applications:current status and future developments . Macromolecules , 2015 . 43 ( 20 ): 8315 - 8330 . http://pubs.acs.org/doi/pdf/10.1021/ma1005815 http://pubs.acs.org/doi/pdf/10.1021/ma1005815 , .

D. Xiong , Y. An , Z. Li , R. Ma , Y. Liu , C. Wu , L. Zou , L. Shi , J. Zhang . Nanometer-scaled hollow spherical micelles with hydrophilic channels and the controlled release of ibuprofen . Macromol. Rapid Commum. , 2008 . 29 ( 23 ): 1895 - 1901 . DOI: 10.1002/marc.v29:23 http://doi.org/10.1002/marc.v29:23 .

H. Yin , H. C. Kang , K. M. Huh , Y. H. Bae . Biocompatible, pH-sensitive AB 2 miktoarm polymer-based polymersomes:preparation, characterization, and acidic pH-activated nanostructural transformation . J. Mater. Chem. , 2012 . 22 ( 36 ): 19168 DOI: 10.1039/c2jm33750a http://doi.org/10.1039/c2jm33750a .

T. Liu , Y. F. Zhang , S. Y. Liu . Drug and plasmid DNA co-delivery nanocarriers based on ABC type polypeptide hybrid miktoarm star copolymers . Chinese J. Polym. Sci. , 2013 . 31 ( 6 ): 924 - 937 . DOI: 10.1007/s10118-013-1281-0 http://doi.org/10.1007/s10118-013-1281-0 .

S. Mura , J. Nicolas , P. Couvreur . Stimuli-responsive nanocarriers for drug delivery . Nat. Mater. , 2013 . 12 ( 11 ): 991 - 1003 . DOI: 10.1038/nmat3776 http://doi.org/10.1038/nmat3776 .

X. Su , M. F. Cunningham , P. G. Jessop . Use of a switchable hydrophobic associative polymer to create an aqueous solution of CO 2 -switchable viscosity . Polym. Chem. , 2013 . 5 ( 3 ): 940 - 944 . http://pubs.rsc.org/en/Content/ArticlePDF/2014/PY/c3py01382k http://pubs.rsc.org/en/Content/ArticlePDF/2014/PY/c3py01382k , .

Z. Guo , Y. Feng , Y. Wang , J. Wang , Y. Wu , Y. Zhang . A novel smart polymer responsive to CO 2 . Chem. Commun. , 2011 . 47 ( 33 ): 9348 - 9350 . DOI: 10.1039/c1cc12388b http://doi.org/10.1039/c1cc12388b .

D. Han , X. Tong , O. Boissière , Y. Zhao . General strategy for making CO 2 -switchable polymers . ACS Macro Lett. , 2011 . 1 ( 1 ): 57 - 61 . http://pubs.acs.org/doi/abs/10.1021/mz2000175 http://pubs.acs.org/doi/abs/10.1021/mz2000175 , .

Q. Yan , R. Zhou , C. Fu , H. Zhang , Y. Yin , J. Yuan . CO 2 -responsive polymeric vesicles that breathe . Angew. Chem. Int. Ed. , 2011 . 50 ( 21 ): 4923 - 4927 . DOI: 10.1002/anie.v50.21 http://doi.org/10.1002/anie.v50.21 .

Q. Yan , J. Wang , Y. Yin , J. Yuan . Breathing polymersomes:CO 2 -tuning membrane permeability for size-selective release, separation, and reaction . Angew. Chem. Int. Ed. , 2013 . 52 ( 19 ): 5070 - 5073 . DOI: 10.1002/anie.201300397 http://doi.org/10.1002/anie.201300397 .

B. Yan , D. Han , O. Boissiere , P. Ayotte , Y. Zhao . Manipulation of block copolymer vesicles using CO 2 :dissociation or "breathing" . Soft Matter , 2013 . 9 ( 6 ): 2011 - 2016 . DOI: 10.1039/c2sm27469h http://doi.org/10.1039/c2sm27469h .

X. Wang , G. Jiang , Z. Wei , X. Li , B. Tang . Preparation and drug release property of CO 2 stimulus-sensitive poly( N , N -dimethylaminoethyl methacrylate)- b -polystyrene nanoparticles . Eur. Polym. J. , 2013 . 49 ( 10 ): 3165 - 3170 . DOI: 10.1016/j.eurpolymj.2013.07.024 http://doi.org/10.1016/j.eurpolymj.2013.07.024 .

S. Das , D. P. Chatterjee , R. Ghosh , P. Das , A. K. Nandi . Water soluble stimuli-responsive star copolymers with multiple encapsulation and release properties . RSC Adv. , 2016 . 6 ( 11 ): 8773 - 8785 . DOI: 10.1039/C5RA26144A http://doi.org/10.1039/C5RA26144A .

C. I. Fowler , P. G. Jessop , M. F. Cunningham . Aryl amidine and tertiary amine switchable surfactants and their application in the emulsion polymerization of methyl methacrylate . Macromolecules , 2012 . 45 ( 7 ): 2955 - 2962 . DOI: 10.1021/ma2027484 http://doi.org/10.1021/ma2027484 .

W. Yuan , J. Zhang , J. Wei , C. Zhang , J. Ren . Synthesis and self-assembly of pH-responsive amphiphilic dendritic star-block terpolymer by the combination of ROP, ATRP and click chemistry . Eur. Polym. J. , 2011 . 47 ( 5 ): 949 - 958 . DOI: 10.1016/j.eurpolymj.2011.01.002 http://doi.org/10.1016/j.eurpolymj.2011.01.002 .

J. Jiang , Q. Shu , X. Chen , Y. Yang , C. Yi , X. Song , X. Liu , M. Chen . Photoinduced morphology switching of polymer nanoaggregates in aqueous solution . Langmuir , 2010 . 26 ( 17 ): 14247 - 14254 . DOI: 10.1021/la102771h http://doi.org/10.1021/la102771h .

Q. Yan , J. Yuan , Z. Cai , Y. Xin , Y. Kang , Y. Yin . Voltage-responsive vesicles based on orthogonal assembly of two homopolymers . J. Am. Chem. Soc. , 2010 . 132 ( 27 ): 9268 - 9270 . DOI: 10.1021/ja1027502 http://doi.org/10.1021/ja1027502 .

浏览量

310

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

The Application of Controlled/Living Radical Polymerization in Modification of PVDF-based Fluoropolymer

Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications

pH-responsive AIE-active Polyethylene-based Block Copolymers

Optically Active Helical Poly(phenyl isocyanide)s Bearing Achiral Benzanilide Pendants: from Controlled Synthesis to Enantioseparation Application

CO2-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

CO2-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

DOI：10.1007/s10118-018-2008-z

摘要

Abstract

关键词

Keywords

references

CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

CO₂-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle