Dual Thermal-and pH-responsive Polypeptide-based Hydrogels

Fan-dong Meng; Yun-xia Ni; Si-fan Ji; Xiao-hui Fu; Yu-han Wei; Jing Sun; Zhi-bo Li

doi:10.1007/s10118-017-1959-9

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Dual Thermal-and pH-responsive Polypeptide-based Hydrogels

Papers | Updated：2021-02-18

- Dual Thermal-and pH-responsive Polypeptide-based Hydrogels
- Dual Thermal-and pH-responsive Polypeptide-based Hydrogels
- Chinese Journal of Polymer Science 2017年35卷第10期页码：1243-1252
- Affiliations：
  
  School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
- Author bio：
  
  Jing Sun (孙静), E-mail:jingsun@qust.edu.cn
  Zhi-bo Li (李志波), E-mail:zbli@qust.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(21434008);the National Natural Science Foundation of China(51225306);Natural Science Foundation of Shandong Province(ZR2015EM015);Taishan Scholars Program;Supplementary material is available in the online version of this article at http://dx.doi.org/10.1007/s10118-017-1959-9.
- DOI：10.1007/s10118-017-1959-9
  中图分类号：
- 收稿：2017-04-07，
  
  修回：2017-4-26，
  
  录用：2017-4-26，
  
  纸质出版：2017-10-05
- Accepted：
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Fan-dong Meng, Yun-xia Ni, Si-fan Ji, 等. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, 2017,35(10):1243-1252.

Fan-dong Meng, Yun-xia Ni, Si-fan Ji, et al. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, 2017, 35(10): 1243-1252.
Fan-dong Meng, Yun-xia Ni, Si-fan Ji, 等. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, 2017,35(10):1243-1252. DOI： 10.1007/s10118-017-1959-9.

Fan-dong Meng, Yun-xia Ni, Si-fan Ji, et al. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, 2017, 35(10): 1243-1252. DOI： 10.1007/s10118-017-1959-9.

摘要

Abstract

Smart hydrogels have received increasing attention for their great potential for the applications in many fields. Herein

we report a facile approach to prepare a class of dual-responsive hydrogels assembled from synthetic statistical/block thermal-responsive copoly(L-glutamate)s copolymerized with poly(ethylene glycol)

which were prepared by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of oligo(ethylene glycol) (OEG) and glutamic acid residues offers the gels with thermal- and pH-responsive properties simultaneously. We have systematically studied the influence of both temperature and pH on the gelation behaviors of these copolymers. It is found that the increase of glutamic acid content and solution pH values can significantly suppress the gelation ability of the samples. Circular dichroism (CD) results show that the

-helix conformation appears to be the dominant secondary conformation. More interestingly

the gelation property of the block copolymer with statistical thermal-responsive copoly(L-glutamate)s shows greater dependence on pH as compared to that with block segments due to the distinct morphology of the self-assemblies. The obtained hydrogels exhibit pH-dependent and thermal-responsive gelation behaviors

which enable them as an ideal smart hydrogel system for biomedical applications.

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Keywords

references

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