Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery

Bei-bei Lu; Lu-lu Wei; Gui-hua Meng; Jun Hou; Zhi-yong Liu; Xu-hong Guo

doi:10.1007/s10118-017-1947-0

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Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery

Papers | Updated：2021-02-18

- Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery
- Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery
- Chinese Journal of Polymer Science 2017年35卷第8期页码：924-938
- Affiliations：
  
  a.School of Chemistry & Chemical Engineering, Shihezi University/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan, Shihezi 832003, China
  b.Department of Immunology, Shihezi University School of Medicine/Department of Pathology and Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi 832003, China
  c.State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
- Author bio：
  
  Zhi-yong Liu (刘志勇), E-mail:lzyongclin@sina.com
- Funds：
  
  the National Natural Science Foundation of China(21367022);Bingtuan Innovation Team in Key Areas(2015BD003)
- DOI：10.1007/s10118-017-1947-0
  中图分类号：
- 收稿：2017-01-14，
  
  修回：2017-2-28，
  
  录用：2017-3-1，
  
  纸质出版：2017-08
- Accepted：
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Bei-bei Lu, Lu-lu Wei, Gui-hua Meng, 等. Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery[J]. Chinese Journal of Polymer Science, 2017,35(8):924-938.

Bei-bei Lu, Lu-lu Wei, Gui-hua Meng, et al. Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(8): 924-938.
Bei-bei Lu, Lu-lu Wei, Gui-hua Meng, 等. Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery[J]. Chinese Journal of Polymer Science, 2017,35(8):924-938. DOI： 10.1007/s10118-017-1947-0.

Bei-bei Lu, Lu-lu Wei, Gui-hua Meng, et al. Synthesis of Self-assemble pH-responsive Cyclodextrin Block Copolymer for Sustained Anticancer Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(8): 924-938. DOI： 10.1007/s10118-017-1947-0.

摘要

Abstract

Well-defined pH-responsive poly(

-caprolactone)-graft-

-cyclodextrin-graft-poly(2-(dimethylamino)ethyl-methacrylate)-

-poly(ethylene glycol) methacrylate amphiphilic copolymers (PCL-

-CD-

-P(DMAEMA-

-PEGMA)) were synthesized using a combination of atom transfer radical polymerization (ATRP)

ring opening polymerization (ROP) and "click" chemistry. Successful synthesis of polymers was confirmed by Fourier transform infrared spectroscopy (FTIR)

proton nuclear magnetic resonance (

H-NMR)

and gel permeation chromatography (GPC). Then

the polymers could self-assemble into micelles in aqueous solution

which was demonstrated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The pH-responsive self-assembly behavior of these copolymers in water was investigated at different pH values of 7.4 and 5.0 for controlled doxorubicin (DOX) release

and these results revealed that the release rate of DOX could be effectively controlled by altering the pH

and the release of drug loading efficiency (DLE) was up to 88% (

W/W

). CCK-8 assays showed that the copolymers had low toxicity and possessed good biodegradability and biocompatibility

whereas the DOX-loaded micelles remained with high cytotoxicity for HeLa cells. Moreover

confocal laser scanning microscopy (CLSM) images revealed that polymeric micelles could actively target the tumor site and the efficient intracellular DOX release from polymeric micelles toward the tumor cells further confirmed the anti-tumor effect. The DOX-loaded micelles could easily enter the cells and produce the desired pharmacological action and minimize the side effect of free DOX. These results successfully indicated that pH-responsive polymeric micelles could be potential hydrophobic drug delivery carriers for cancer targeting therapy with sustained release.

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references

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