Poly(<italic style="font-style: italic">β</italic>-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

Xiang-ru Feng; Jian-xun Ding; Ruxandra Gref; Xue-si Chen

doi:10.1007/s10118-017-1932-7

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Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

Rapid Communications | Updated：2021-02-18

- Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery
- Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery
- Chinese Journal of Polymer Science 2017年35卷第6期页码：693-699
- Affiliations：
  
  a.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  b.Institute of Molecular Sciences, CNRS, Université Paris-Sud, Université Paris Saclay, Orsay 91400, France
- Author bio：
  
  Jian-xun Ding (丁建勋), E-mail: jxding@caic.ac.cn
  Ruxandra Gref, E-mail: ruxandra.gref@u-psud.fr
- Funds：
  
  financially supported by the National Natural Science Foundation of China(51673190);financially supported by the National Natural Science Foundation of China(51303174);financially supported by the National Natural Science Foundation of China(51603204);financially supported by the National Natural Science Foundation of China(51390484)
- DOI：10.1007/s10118-017-1932-7
  中图分类号：
- 收稿：2016-12-27，
  
  修回：2017-1-20，
  
  录用：2017-1-23，
  
  纸质出版：2017-06-05
- Accepted：
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Xiang-ru Feng, Jian-xun Ding, Ruxandra Gref, 等. Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery[J]. Chinese Journal of Polymer Science, 2017,35(6):693-699. DOI: 10.1007/s10118-017-1932-7.

Xiang-ru Feng, Jian-xun Ding, Ruxandra Gref, et al. Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(6): 693-699. DOI: 10.1007/s10118-017-1932-7.
Xiang-ru Feng, Jian-xun Ding, Ruxandra Gref, 等. Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery[J]. Chinese Journal of Polymer Science, 2017,35(6):693-699. DOI: 10.1007/s10118-017-1932-7. DOI：

Xiang-ru Feng, Jian-xun Ding, Ruxandra Gref, et al. Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(6): 693-699. DOI: 10.1007/s10118-017-1932-7. DOI：

摘要

Abstract

A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared

via

the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-

-PLLA/PDLA-CHOL) and poly(

-cyclodextrin) (PCD) with the molar ratios of CHOL/

-CD at 1:0.5

1:1

and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/

-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release

cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.

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J. Ding , F. Shi , D. Li , L. Chen , X. Zhuang , X. Chen . . Biomater. Sci. , 2013 . 1 ( 6 ): 633 DOI: 10.1039/C3BM60024F http://doi.org/10.1039/C3BM60024F .

Washington, K.E., Kularatne, R.N., Karmegam, V., Biewer, M.C. and Stefan, M.C., WIRES: Nanomed. Nanobiotechnol., 2017, 10.1002/wnan.1446

D.H. Liu , J.X. Ding , W.G. Xu , X.F. Song , X.L. Zhuang , X.S. Chen . . Acta Polymerica Sinica , 2014 . ( 9 ): 1265 http://www.gfzxb.org/EN/Y2014/V0/I9/1265 http://www.gfzxb.org/EN/Y2014/V0/I9/1265 , .

Y.T. Tam , J. Gao , G.S. Kwon . . J. Am. Chem. Soc. , 2016 . 138 ( 28 ): 8674 DOI: 10.1021/jacs.6b03995 http://doi.org/10.1021/jacs.6b03995 .

J. Ding , L. Chen , C. Xiao , L. Chen , X. Zhuang , X. Chen . . Chem. Commun. , 2014 . 50 ( 77 ): 11274 DOI: 10.1039/C4CC03153A http://doi.org/10.1039/C4CC03153A .

N. Kang , M.È. Perron , R.E. Prud'Homme , Y. Zhang , G. Gaucher , J.C. Leroux . . Nano Lett. , 2005 . 5 ( 2 ): 315 DOI: 10.1021/nl048037v http://doi.org/10.1021/nl048037v .

L. Yang , Z. Zhao , J. Wei , A. El Ghzaoui , S. Li . . J. Colloid Interf. Sci. , 2007 . 314 ( 2 ): 470 DOI: 10.1016/j.jcis.2007.05.074 http://doi.org/10.1016/j.jcis.2007.05.074 .

C. Ma , P. Pan , G. Shan , Y. Bao , M. Fujita , M. Maeda . . Langmuir , 2015 . 31 ( 4 ): 1527 DOI: 10.1021/la503869d http://doi.org/10.1021/la503869d .

L. Chen , Z. Xie , J. Hu , X. Chen , X. Jing . . J. Nanopart. Res. , 2007 . 9 ( 5 ): 777 DOI: 10.1007/s11051-006-9103-8 http://doi.org/10.1007/s11051-006-9103-8 .

C. Heinzmann , C. Weder , L.M. de Espinosa . . Chem. Soc. Rev. , 2016 . 45 ( 2 ): 342 DOI: 10.1039/C5CS00477B http://doi.org/10.1039/C5CS00477B .

L. Voorhaar , R. Hoogenboom . . Chem. Soc. Rev. , 2016 . 45 ( 14 ): 4013 DOI: 10.1039/C6CS00130K http://doi.org/10.1039/C6CS00130K .

C. Xiao , Y. Cheng , Y. Zhang , J. Ding , C. He , X. Zhuang , X. Chen . . J. Polym. Sci., Part A: Polym. Chem. , 2014 . 52 ( 5 ): 671 DOI: 10.1002/pola.27048 http://doi.org/10.1002/pola.27048 .

Q. Jiang , Y. Zhang , R. Zhuo , X. Jiang . . Colloid Surface B , 2016 . 147 25 DOI: 10.1016/j.colsurfb.2016.07.028 http://doi.org/10.1016/j.colsurfb.2016.07.028 .

B.Y. Guan , L. Yu , X.W. Lou . . Adv. Mater. , 2016 . 28 ( 43 ): 9596 DOI: 10.1002/adma.201603622 http://doi.org/10.1002/adma.201603622 .

Y. Zhang , C. Xiao , M. Li , J. Chen , J. Ding , C. He , X. Zhuang , X. Chen . . Macromol. Biosci. , 2013 . 13 ( 5 ): 584 DOI: 10.1002/mabi.201200441 http://doi.org/10.1002/mabi.201200441 .

Y. Umezaki , D. Iohara , M. Anraku , Y. Ishitsuka , T. Irie , K. Uekama , F. Hirayama . . Biomaterials , 2015 . 45 115 DOI: 10.1016/j.biomaterials.2014.12.032 http://doi.org/10.1016/j.biomaterials.2014.12.032 .

Y. Kang , X. Tang , Z. Cai , X. Zhang . . Adv. Funct. Mater. , 2016 . 26 ( 48 ): 8920 DOI: 10.1002/adfm.v26.48 http://doi.org/10.1002/adfm.v26.48 .

L. Chen , Z. Zhang , X. Chen , X. Yao , C. He , X. Chen . . Acta Biomater. , 2015 . 18 168 DOI: 10.1016/j.actbio.2015.02.029 http://doi.org/10.1016/j.actbio.2015.02.029 .

G. Rassu , E. Soddu , M. Cossu , A. Brundu , G. Cerri , N. Marchetti , L. Ferraro , R.F. Regan , P. Giunchedi , E. Gavini , A. Dalpiaz . . J. Control. Release , 2015 . 201 68 DOI: 10.1016/j.jconrel.2015.01.025 http://doi.org/10.1016/j.jconrel.2015.01.025 .

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Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

DOI：10.1007/s10118-017-1932-7

摘要

Abstract

关键词

Keywords

references