Temperature and pH Dually-responsive Poly (<italic style="font-style: italic">β</italic>-amino ester) Nanoparticles for Drug Delivery

Xiao-ju Lu; Xiang-yu Yang; Yuan Meng; Shao-zhen Li

doi:10.1007/s10118-017-1916-7

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Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery

Papers | Updated：2021-02-18

- Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery
- Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery
- Chinese Journal of Polymer Science 2017年35卷第4期页码：534-546
- Affiliations：
  
  School of Chemical and Material Engineering and Institute of Quantum Materials, Hubei Polytechnic University, Huangshi 435003, China
- Author bio：
  
  Xiao-ju Lu (卢小菊), E-mail:xiaoju_lu@163.com
- Funds：
  
  the National Natural Science Foundation of China(51402099);Education Foundation of Hubei Province(T201521);the Science Foundation from Hubei Polytechnic University(12xjz08R);the Science Foundation from Hubei Polytechnic University(801-8596)
- DOI：10.1007/s10118-017-1916-7
  中图分类号：
- 收稿：2016-08-11，
  
  修回：2016-10-21，
  
  录用：2016-10-22，
  
  纸质出版：2017-04
- Accepted：
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Xiao-ju Lu, Xiang-yu Yang, Yuan Meng, 等. Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery[J]. Chinese Journal of Polymer Science, 2017,35(4):534-546. DOI: 10.1007/s10118-017-1916-7.

Xiao-ju Lu, Xiang-yu Yang, Yuan Meng, et al. Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(4): 534-546. DOI: 10.1007/s10118-017-1916-7.
Xiao-ju Lu, Xiang-yu Yang, Yuan Meng, 等. Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery[J]. Chinese Journal of Polymer Science, 2017,35(4):534-546. DOI: 10.1007/s10118-017-1916-7. DOI：

Xiao-ju Lu, Xiang-yu Yang, Yuan Meng, et al. Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery[J]. Chinese Journal of Polymer Science, 2017, 35(4): 534-546. DOI: 10.1007/s10118-017-1916-7. DOI：

摘要

Abstract

Stimuli-responsive polymers have undoubtedly been of great interest in the past decades due to a variety of their potential applications in biomedical territory. However

their non-degradability limits their

in vivo

applications. Herein

we report a novel pH and temperature dual-stimuli responsive-poly (

-amino ester). The pH/temperature sensitivities are interrelated and can be easily tuned by changing PEG-diacrylate chain length and the percentage of biamines in the feed ratio. These dual-responsive polymers are very useful in drug delivery. Reaction of methyl ether poly (ethylene glycol) (MPEG) and poly (

-amino ester) resulted in an amphiphilic MPEG-PBAE block copolymer which could form nanoparticles by self-assembly. A hydrophobic drug (DOX) was loaded in the self-assembled nanoparticles at low temperature without using organic solvents. The loaded drug was released very slowly and steadily at 37℃ under physiological conditions (pH 7.4)

but rapidly released from the micelles in weakly acidic environments (pH 6.4 and 5.0) for intracellular drug release. Thus

these poly (

-amino ester) polymers constitute ideal drug carriers since their thermal sensitivity allows the drug loadings without using organic solvent and their pH sensitivity permits fast intracellular drug release.

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Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery

DOI：10.1007/s10118-017-1916-7

摘要

Abstract

关键词

Keywords

references