Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring <italic style="font-style: italic">β</italic>-Cyclodextrin-conjugated PEG-PLGA Copolymers

Ji-jie Wen; Hong-guang Lu; De-e Liu; Hui Gao

doi:10.1007/s10118-016-1789-1

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Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers

Papers | Updated：2022-02-21

- Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers
- Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers
- 高分子科学（英文版） 2016年34卷第6期页码：730-738
- Affiliations：
  
  School of Chemistry and Chemical Engineering, Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, Tianjin University of Technology, Tianjin 300384, China
- Author bio：
  
  Hong-guang Lu ,E-mail: hglu@tjut.edu.cn
  Hui Gao,E-mail: hgao@tjut.edu.cn or ghhigher@hotmail.com
- Funds：
  
  the National Natural Science Foundation of China;Program for New Century Excellent Talents in Universities;Program for Prominent Young College Teachers of Tianjin Educational Committee.();ACKNOWLEDGEMENTS Hui Gao and Hongguang Lu are grateful for the support from 131 talents program of Tianjin.()
- DOI：10.1007/s10118-016-1789-1
  中图分类号：
- 收稿：2015-12-11，
  
  修回：2016-01-31，
  
  录用：2015-12-22，
  
  纸质出版：2016-06
- Accepted：
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Ji-jie Wen, Hong-guang Lu, De-e Liu, 等. Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers[J]. 高分子科学（英文版）, 2016,34(6):730-738. DOI: 10.1007/s10118-016-1789-1.

Ji-jie Wen, Hong-guang Lu, De-e Liu, et al. Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers[J]. 2016, 34(6): 730-738. DOI: 10.1007/s10118-016-1789-1.
Ji-jie Wen, Hong-guang Lu, De-e Liu, 等. Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers[J]. 高分子科学（英文版）, 2016,34(6):730-738. DOI: 10.1007/s10118-016-1789-1. DOI：

Ji-jie Wen, Hong-guang Lu, De-e Liu, et al. Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers[J]. 2016, 34(6): 730-738. DOI: 10.1007/s10118-016-1789-1. DOI：

摘要

Abstract

A series of

-cyclodextrin-conjugated 4-arm poly(ethylene glycol)-poly(lactide-

-glycolide) (4-arm PEG-PLGA) copolymers were synthesized by a ring-opening polymerization of D

L-lactide and glycolide using 4-arm PEG as initiator

and then conjugated with mono(6-ethylenediamine-6-deoxy)-

-cyclodextrin (CDen) or ethylenediamino-bridged bis-

-CD (BCDen). The chemical structures of copolymers were confirmed by

H-NMR and FTIR spectroscopy. The

-CD-conjugated PEG-PLGA formed stable reverse micelles due to the formation of

-CD and bovine serum albumin (BSA) inclusion complexation

which could accommodate BSA in the organic solvent with improved encapsulation efficiency. Moreover

we demonstrated a one-step approach to construct macroporous protein-containing films using these reverse micelles. The films with ordered pore arrays were directly prepared from reverse micelles. Interestingly

the protein was totally located in the whole matrix except for the pores.

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references

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Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers

Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers

DOI：10.1007/s10118-016-1789-1

摘要

Abstract

关键词

Keywords

references