Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems

Song Yuan-qing; Gao Yun-long; Pan Zhi-cheng; Zhang Yi; Li Jie-hua; Wang Kun-jie; Li Jian-shu; Tan Hong; Fu Qiang

doi:10.1007/s10118-016-1787-3

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Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems

Papers | Updated：2022-02-21

- Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems
- Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems
- 高分子科学（英文版） 2016年34卷第6期页码：679-687
- Affiliations：
  
  a.College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
  b.Department of Urology, West China Hospital, Huaxi Clinical College, Sichuan University, Chengdu 610065, China
  c.Research Institute for Strengthening Technology, Sichuan Institute of Building Research, Chengdu 610081, China
- Author bio：
  
  Jie-hua Li (李洁华), E-mail: jiehua_li@scu.edu.cn
  Hong Tan (̷谭鸿), E-mail: hongtan@scu.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China(Nos. 51173118, 51273124 and 51273126);the National Science Fund for Distinguished Young Scholars of China(No. 51425305);the Youth Science and Technology Innovation Team of Sichuan Province(No. 2015TD0001);and State Key Laboratory of Polymer Materials Engineering(No. sklpme2014-2-03)
- DOI：10.1007/s10118-016-1787-3
  中图分类号：
- 收稿：2015-11-21，
  
  修回：2016-1-24，
  
  录用：2016-2-2，
  
  纸质出版：2016-06
- Accepted：
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Song Yuan-qing, Gao Yun-long, Pan Zhi-cheng, 等. Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems[J]. 高分子科学（英文版）, 2016,34(6):679-687.

Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems[J]. 2016, 34(6): 679-687.
Song Yuan-qing, Gao Yun-long, Pan Zhi-cheng, 等. Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems[J]. 高分子科学（英文版）, 2016,34(6):679-687. DOI： 10.1007/s10118-016-1787-3.

Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems[J]. 2016, 34(6): 679-687. DOI： 10.1007/s10118-016-1787-3.

摘要

Abstract

In this study

to improve hemocompatibility of biomedical materials

a waterborne polyurethane (WPU)/heparin release coating system (WPU/heparin) is fabricated

via

simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin

as determined by the toluidine blue method. Furthermore

the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption

platelet adhesion

activated partial thromboplastin time (APTT)

thrombin time (TT)

hemolysis

and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus

the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.

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Keywords

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