Emulsifier-free Emulsion Polymerized Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging

Chen Hu; Tian Xia; Ying Gong; Xin Wang; Ruan-qing Liu; Quan-yuan Zhang; Chang-feng Yi; Zu-shun Xu; Ding-zong Guo

doi:10.1007/s10118-016-1739-y

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Emulsifier-free Emulsion Polymerized Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging

Updated：2021-06-21

- Emulsifier-free Emulsion Polymerized Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging
- Emulsifier-free Emulsion Polymerized Poly(MMA-HEMAEu-AA)₃Phen)/Fe₃O₄ Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging
- Chinese Journal of Polymer Science 2016年34卷第2期页码：135-146
- Affiliations：
  
  a.Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Material, Hubei University, Wuhan 430062, China
  b.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
- Author bio：
  
  †These two authors contributed equally to this project.
  **Zu-shun Xu (徐祖顺), E-mail: zushunxu@hubu.edu.cn
  Ding-zong Guo (郭定宗), E-mail: hlgdz@163.com
- Funds：
  
  National Natural Science Foundation of China(51273058);National Key Technology R&D Program of China(2012BAD12B03)
- DOI：10.1007/s10118-016-1739-y
  中图分类号：
- 收稿：2015-06-17，
  
  修回：2015-08-24，
  
  录用：2015-09-04，
  
  纸质出版：2016-02
- Accepted：
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Chen Hu, Tian Xia, Ying Gong, 等. Emulsifier-free Emulsion Polymerized Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging[J]. Chinese Journal of Polymer Science, 2016,34(2):135-146.

Chen Hu, Tian Xia, Ying Gong, et al. Emulsifier-free Emulsion Polymerized Poly(MMA-HEMAEu-AA)₃Phen)/Fe₃O₄ Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging[J]. Chinese Journal of Polymer Science, 2016, 34(2): 135-146. DOI: 10.1007/s10118-016-1739-y.
Chen Hu, Tian Xia, Ying Gong, 等. Emulsifier-free Emulsion Polymerized Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging[J]. Chinese Journal of Polymer Science, 2016,34(2):135-146. DOI： 10.1007/s10118-016-1739-y.

Chen Hu, Tian Xia, Ying Gong, et al. Emulsifier-free Emulsion Polymerized Poly(MMA-HEMAEu-AA)₃Phen)/Fe₃O₄ Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging[J]. Chinese Journal of Polymer Science, 2016, 34(2): 135-146. DOI: 10.1007/s10118-016-1739-y. DOI：

摘要

Abstract

Integration of biocompatibility with superparamagnetic Fe

nanoparticles and luminescence rare earth complexes Eu(AA)

Phen was carried out to form bifunctional nanospheres for using in bioimaging applications. The nanospheres Poly(MMA-HEMA-Eu(AA)

Phen)/Fe

exhibit magnetic and fluorescent properties that are favorable for the use in drug delivery

magnetic separation and MR imaging for biomedical research. The TEM and SEM studies reveal that the bifunctional nanospheres have core-shell structure

in a spherical shape with a size ranging from 140 nm to 180 nm. In MRI experiments

a clear negative contrast enhancement in

images and the

reaches 568.82 (mmol·L

-1

)

-1

·s

-1

In vivo

magnetic and fluorescence resonance imaging results suggest the nanospheres are able to preferentially accumulate in liver and spleen tissues to allow dual-modal detection of cancer cells in a living body.

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