Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach

Xiao-jiu Liu; Ye-min Zhang; Xin-song Li

doi:10.1007/s10118-015-1717-9

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Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach

PAPER | Updated：2021-06-21

- Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach
- Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach
- Chinese Journal of Polymer Science 2015年33卷第12期页码：1741-1749
- Affiliations：
  
  School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210018, China
- Author bio：
  
  **Xin-song Li (李新松), E-mail: lixs@seu.edu.cn
- Funds：
  
  National Natural Science Foundation of China(51373034;51073036)
- DOI：10.1007/s10118-015-1717-9
  中图分类号：
- 收稿：2015-05-28，
  
  修回：2015-06-18，
  
  录用：2015-06-19，
  
  纸质出版：2015-12
- Accepted：
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Xiao-jiu Liu, Ye-min Zhang, Xin-song Li. Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach[J]. Chinese Journal of Polymer Science, 2015,33(12):1741-1749.

Xiao-jiu Liu, Ye-min Zhang, Xin-song Li. Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach[J]. Chinese Journal of Polymer Science, 2015, 33(12): 1741-1749.
Xiao-jiu Liu, Ye-min Zhang, Xin-song Li. Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach[J]. Chinese Journal of Polymer Science, 2015,33(12):1741-1749. DOI： 10.1007/s10118-015-1717-9.

Xiao-jiu Liu, Ye-min Zhang, Xin-song Li. Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach[J]. Chinese Journal of Polymer Science, 2015, 33(12): 1741-1749. DOI： 10.1007/s10118-015-1717-9.

摘要

Abstract

In this report

bienzymatic crosslinking approach was applied to prepare biopolymer hydrogel fibers composed of gelatin and chitosan with an interpenetrating polymer network (IPN) structure. The IPN biopolymer hydrogel fibers were prepared by wet spinning while microbial transglutaminase (mTG) catalyzed the formation of one network of gelatin and horseradish peroxidase (HRP) in the presence of H

induced another network of chitosan grafted with phloretic acid (chitosan-PA) intertwining with the former. The mechanical performances of the hydrogel fibers were measured by an electronic single fiber strength tester. It was found that the mechanical properties of the gelatin/chitosan IPN hydrogel fibers had a significant improvement with the increase of the concentration of gelatin and chitosan

and the IPN fiber has the highest tension of 38.6 cN and elongation of 387.2%. Accelerated degradation in the presence of papin indicated that the gelatin/chitosan-PA IPN hydrogel fibers own controllable degradability. In addition

biological evaluation indicated the IPN hydrogel fibers can support cell adhesion and proliferation. Moreover

hand weaving trail showed the knittablity of the IPN hydrogel fibers. Therefore

the gelatin/chitosan IPN hydrogel fibers prepared by bienzymatic crosslinking approach possess excellent biocompatibility and mechanical strength

which may be desirable candidates for engineering tissue scaffolds.

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