Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release

Yin Yuan; Pei-jian Sun; Xu-dong Shi; Zhi-hua Gan; Fo-song Wang

doi:10.1007/s10118-015-1702-3

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Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release

PAPER | Updated：2021-06-21

- Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release
- Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release
- Chinese Journal of Polymer Science 2015年33卷第11期页码：1598-1605
- Affiliations：
  
  a.CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Sciences and Technology, Beijing 100029, China
- Author bio：
  
  **Pei-jian Sun (孙培健), E-mail: pjsun@iccas.ac.cn
  Fo-song Wang (王佛松), E-mail: wangfs@iccas.ac.cn
- Funds：
  
  National Natural Science Foundation of China(51025314;51390481)
- DOI：10.1007/s10118-015-1702-3
  中图分类号：
- 收稿：2015-04-23，
  
  录用：2015-04-28，
  
  纸质出版：2015-11
- Accepted：
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Yin Yuan, Pei-jian Sun, Xu-dong Shi, 等. Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release[J]. Chinese Journal of Polymer Science, 2015,33(11):1598-1605.

Yin Yuan, Pei-jian Sun, Xu-dong Shi, et al. Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release[J]. Chinese Journal of Polymer Science, 2015, 33(11): 1598-1605. DOI: 10.1007/s10118-015-1702-3.
Yin Yuan, Pei-jian Sun, Xu-dong Shi, 等. Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release[J]. Chinese Journal of Polymer Science, 2015,33(11):1598-1605. DOI： 10.1007/s10118-015-1702-3.

Yin Yuan, Pei-jian Sun, Xu-dong Shi, et al. Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release[J]. Chinese Journal of Polymer Science, 2015, 33(11): 1598-1605. DOI: 10.1007/s10118-015-1702-3. DOI：

摘要

Abstract

Microspheres with thermo-responsible surface were fabricated by PCL-

-PEO-

-PNIPAM triblock copolymers. Thermo-responsible morphological changes of PCL-

-PEO-

-PNIPAM microspheres immersed in aqueous solution at temperatures above the LCST (

e.g.

37 °C) were observed from porous surface structure to compact surface layer. Enzymatic degradation and

in vitro

drug release results showed that the thermo-responsible surface layer greatly influenced the degradation of microspheres as well as the drug release behavior from microspheres. With the copolymerization of PNIPAM block into PCL-

-PEO copolymers

the drug release could be well regulated by changing temperatures and microspheres composition

which revealed the great potentials of microspheres with thermo-responsible surface for controlled drug release.

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