Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-Lleucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine

Ce Tian; Jun Ling; You-qing Shen

doi:10.1007/s10118-015-1669-0

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Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-Lleucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine

PAPER | Updated：2021-06-21

- Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-Lleucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine
- Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-L-leucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine
- Chinese Journal of Polymer Science 2015年33卷第8期页码：1186-1195
- Affiliations：
  
  a.MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  b.Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  **Jun Ling (凌君), E-mail: lingjun@zju.edu.cn
- Funds：
  
  National Natural Science Foundation of China(21174122;51390481)
- DOI：10.1007/s10118-015-1669-0
  中图分类号：
- 收稿：2015-01-05，
  
  修回：2015-02-06，
  
  录用：2015-02-07，
  
  纸质出版：2015-08
- Accepted：
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Ce Tian, Jun Ling, You-qing Shen. Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-Lleucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine[J]. Chinese Journal of Polymer Science, 2015,33(8):1186-1195.

Ce Tian, Jun Ling, You-qing Shen. Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-L-leucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine[J]. Chinese Journal of Polymer Science, 2015, 33(8): 1186-1195. DOI: 10.1007/s10118-015-1669-0.
Ce Tian, Jun Ling, You-qing Shen. Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-Lleucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine[J]. Chinese Journal of Polymer Science, 2015,33(8):1186-1195. DOI： 10.1007/s10118-015-1669-0.

Ce Tian, Jun Ling, You-qing Shen. Self-assembly and pH-Responsive Properties of Poly(L-glutamic acid-r-L-leucine) and Poly(L-glutamic acid-r-L-leucine)-b-Polysarcosine[J]. Chinese Journal of Polymer Science, 2015, 33(8): 1186-1195. DOI: 10.1007/s10118-015-1669-0. DOI：

摘要

Abstract

Polypeptides and polypeptoids were widely used as biomedical materials because of their good biocompatibility. In this work we reported a series of pH-responsive copolypeptides and polypeptide-polypeptoid block copolymers

i.e.

random copolymers of L-glutamic acid (Glu) with L-leucine (Leu) [poly(Glu-

-Leu)s]

as well as their block copolymers with polysarcosine (polySar). Well-defined poly(Glu-

-Leu)s with predictable compositions and molecular weights were synthesized by ring opening polymerization of corresponding

-carboxyanhydride monomers. We investigated the relationship between hydrophilicity-hydrophobicity transition and copolymer composition. With increasing Leu fraction

both the pH value of cloud point and the micellar size increased. Poly(Glu-

-Leu) with 60% Leu exhibited a cloud point at the pH of 5.0 to 6.0 the same as that in endosome and lysosome. Poly(Glu-

-Leu)-

-polySars assembled in phosphate buffer and performed pH-responsive morphology change from orbicular micelles at high pH to worm-like micelles at low pH. They were potential pH-responsive carriers for drug and gene delivery to enhance cargo release in cellules.

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