Comparation of Activity against A Aggregation between RR and LPFFD

Jing Liu; Zhi Yuan

doi:10.1007/s10118-015-1646-7

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Comparation of Activity against A Aggregation between RR and LPFFD

PAPER | Updated：2021-06-21

- Comparation of Activity against A Aggregation between RR and LPFFD
- Comparation of Activity against Aβ Aggregation between RR and LPFFD
- Chinese Journal of Polymer Science 2015年33卷第7期页码：1009-1017
- Affiliations：
  
  Key Laboratory of Functional Polymer Materials of Ministry of Education, and Institute of Polymer Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China
- Author bio：
  
  **Zhi Yuan (袁直), E-mail: zhiy@nankai.edu.cn
- Funds：
  
  National Natural Science Foundation of China(20634030;51273094);Ministry of Science and Technology of China(2011CB606202);PCSIRT(IRT1257)
- DOI：10.1007/s10118-015-1646-7
  中图分类号：
- 收稿：2014-10-30，
  
  修回：2015-01-07，
  
  录用：2015-01-13，
  
  纸质出版：2015-07
- Accepted：
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Jing Liu, Zhi Yuan. Comparation of Activity against A Aggregation between RR and LPFFD[J]. Chinese Journal of Polymer Science, 2015,33(7):1009-1017.

Jing Liu, Zhi Yuan. Comparation of Activity against Aβ Aggregation between RR and LPFFD[J]. Chinese Journal of Polymer Science, 2015, 33(7): 1009-1017. DOI: 10.1007/s10118-015-1646-7.
Jing Liu, Zhi Yuan. Comparation of Activity against A Aggregation between RR and LPFFD[J]. Chinese Journal of Polymer Science, 2015,33(7):1009-1017. DOI： 10.1007/s10118-015-1646-7.

Jing Liu, Zhi Yuan. Comparation of Activity against Aβ Aggregation between RR and LPFFD[J]. Chinese Journal of Polymer Science, 2015, 33(7): 1009-1017. DOI: 10.1007/s10118-015-1646-7. DOI：

摘要

Abstract

Here

we introduce the design of the structure of RR (RYYAAFFARR)

an inhibitor of A

aggregation

using molecular docking

and compare the inhibitory ability between RR and LPFFD

which interacts with A

mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of A

with multiple weak interactions is better than those that only target a single region with the single driving force mainly.

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