Doxorubicin-loaded PLGA Microparticles with Internal Pores for Long-acting Release in Pulmonary Tumor Inhalation Treatment

Tian-shi Feng; Hua-yu Tian; Cai-na Xu; Lin Lin; Michael Hon-Wah Lam; Hao-jun Liang; Xue-si Chen

doi:10.1007/s10118-015-1642-y

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Doxorubicin-loaded PLGA Microparticles with Internal Pores for Long-acting Release in Pulmonary Tumor Inhalation Treatment

PAPER | Updated：2021-06-21

- Doxorubicin-loaded PLGA Microparticles with Internal Pores for Long-acting Release in Pulmonary Tumor Inhalation Treatment
- Doxorubicin-loaded PLGA Microparticles with Internal Pores for Longacting Release in Pulmonary Tumor Inhalation Treatment
- Chinese Journal of Polymer Science 2015年33卷第7期页码：947-954
- Affiliations：
  
  a.CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China
  b.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China
  d.Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-City U, Suzhou 215124, China
- Author bio：
  
  **Hua-yu Tian (田华雨), E-mail: thy@ciac.ac.cn
- Funds：
  
  National Natural Science Foundation of China(51222307;51303173;51390480;21474104;51403205);Ministry of Science and Technology of China(2011DFR51090);Jilin Province Science and Technology Development Program(20120306;20130521011JH)
- DOI：10.1007/s10118-015-1642-y
  中图分类号：
- 收稿：2014-10-23，
  
  修回：2014-11-06，
  
  录用：2014-11-27，
  
  纸质出版：2015-07
- Accepted：
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Tian-shi Feng, Hua-yu Tian, Cai-na Xu, 等. Doxorubicin-loaded PLGA Microparticles with Internal Pores for Long-acting Release in Pulmonary Tumor Inhalation Treatment[J]. Chinese Journal of Polymer Science, 2015,33(7):947-954.

Tian-shi Feng, Hua-yu Tian, Cai-na Xu, et al. Doxorubicin-loaded PLGA Microparticles with Internal Pores for Longacting Release in Pulmonary Tumor Inhalation Treatment[J]. Chinese Journal of Polymer Science, 2015, 33(7): 947-954.
Tian-shi Feng, Hua-yu Tian, Cai-na Xu, 等. Doxorubicin-loaded PLGA Microparticles with Internal Pores for Long-acting Release in Pulmonary Tumor Inhalation Treatment[J]. Chinese Journal of Polymer Science, 2015,33(7):947-954. DOI： 10.1007/s10118-015-1642-y.

Tian-shi Feng, Hua-yu Tian, Cai-na Xu, et al. Doxorubicin-loaded PLGA Microparticles with Internal Pores for Longacting Release in Pulmonary Tumor Inhalation Treatment[J]. Chinese Journal of Polymer Science, 2015, 33(7): 947-954. DOI： 10.1007/s10118-015-1642-y.

摘要

Abstract

Doxorubicin (DOX) loaded poly(lactic-

-glycolic acid) (PLGA) microparticles with internal pores (MP-D) were developed for long-acting release in pulmonary inhalation treatment. The PLGA microparticles exhibited favorable aerodynamic properties for pulmonary delivery.

In vitro

drug release profile suggested that MP-D have the advantage of long-term maintenance of drug concentrations. MTT assay demonstrated the

in vitro

anti-tumor efficiency of the DOX loaded PLGA microparticles. Furthermore

melanoma lung metastasis model was established to determine the

in vivo

antitumor efficiency. The mice treated with MP-D showed significantly fewer lesions than the untreated ones. The survival analysis indicated that MP-D prolonged the survival time of tumor-bearing mice. These results suggested that DOX loaded PLGA microparticles with internal pores have the potential to be used as long-acting release carriers in clinical lung cancer treatment.

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