Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin

Lian-ying Wu; Lei Yu; Xiao-hui Fu; Zhi-bo Li

doi:10.1007/s10118-015-1640-0

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Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin

PAPER | Updated：2021-06-21

- Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin
- Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with α-Cyclodextrin
- Chinese Journal of Polymer Science 2015年33卷第8期页码：1140-1149
- Affiliations：
  
  Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
- Author bio：
  
  **Zhi-bo Li (李志波), E-mail: zbli@iccas.ac.cn
- Funds：
  
  the National Natural Science Foundation of China(51225306);the National Natural Science Foundation of China(21434008)
- DOI：10.1007/s10118-015-1640-0
  中图分类号：
- 收稿：2014-12-03，
  
  修回：2015-01-16，
  
  录用：2015-01-16，
  
  纸质出版：2015-08
- Accepted：
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Lian-ying Wu, Lei Yu, Xiao-hui Fu, 等. Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin[J]. Chinese Journal of Polymer Science, 2015,33(8):1140-1149.

Lian-ying Wu, Lei Yu, Xiao-hui Fu, et al. Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with α-Cyclodextrin[J]. Chinese Journal of Polymer Science, 2015, 33(8): 1140-1149. DOI: 10.1007/s10118-015-1640-0.
Lian-ying Wu, Lei Yu, Xiao-hui Fu, 等. Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin[J]. Chinese Journal of Polymer Science, 2015,33(8):1140-1149. DOI： 10.1007/s10118-015-1640-0.

Lian-ying Wu, Lei Yu, Xiao-hui Fu, et al. Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with α-Cyclodextrin[J]. Chinese Journal of Polymer Science, 2015, 33(8): 1140-1149. DOI: 10.1007/s10118-015-1640-0. DOI：

摘要

Abstract

A series of monomethoxy poly(ethylene glycol) (mPEG) grafted copolyglutamates (PmPEGs) were synthesized through ring-opening polymerization (ROP) followed by click chemistry. Supramolecular hydrogels based on polymer inclusion complexes (ICs) between PmPEG and a-cyclodextrin (

-CD) were prepared in aqueous solution. The rheological measurements indicated their gelation properties were affected by several factors including the mPEG length

graft density and the sample concentration. These hydrogels displayed thermo-sensitive gel-sol transition under appropriate conditions due to the reversible mPEG and

-CD inclusion complexation. These hydrogels also showed pH-sensitive behavior due to the deprotonate of carboxylic acid side groups. The ICs formation of a channel-type crystalline structure induced gelation mechanism was verified by various techniques.

In vitro

cytotoxicity assays demonstrated that the supramolecular hydrogels are nontoxic and cytocompatible.

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