Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma

Yi-fei Li; Hai-yang Yu; Hai Sun; Jian-guo Liu; Zhao-hui Tang; Dan Wang; Lian-you Yu; Xue-si Chen

doi:10.1007/s10118-015-1624-0

Your Location：

Home >

Browse articles >

Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma

PAPER | Updated：2021-06-21

- Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma
- Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma
- Chinese Journal of Polymer Science 2015年33卷第5期页码：763-771
- Affiliations：
  
  a.Departemnt of Orthopaedics, the Norman Bethune First Hospital of Jilin University, Changchun 130021, China
  b.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Jilin Central Hospital, Jilin 132011, China
  d.Basic Medical College, Beihua University, Jilin 132013, China
  e.The Hospital of Jilin Chemical Industry Company, Jilin 132021, China
- Author bio：
  
  **Jian-guo Liu (刘建国), E-mail: jgliu.2005@aliyun.com
  Zhao-hui Tang (汤朝晖), E-mail: ztang@ciac.ac.cn
- Funds：
  
  National Natural Science Foundation of China(51373168;51233004;21104076;51321062;51390484);Ministry of Science and Technology of China(2011DFR51090);Program of Scientific Development of Jilin Province(20130206066GX;20130727050YY;20130521011JH)
- DOI：10.1007/s10118-015-1624-0
  中图分类号：
- 收稿：2014-09-17，
  
  修回：2014-10-21，
  
  录用：2014-10-28，
  
  纸质出版：2015-05
- Accepted：
Scan QR Code
Yi-fei Li, Hai-yang Yu, Hai Sun, 等. Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma[J]. Chinese Journal of Polymer Science, 2015,33(5):763-771.

Yi-fei Li, Hai-yang Yu, Hai Sun, et al. Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma[J]. Chinese Journal of Polymer Science, 2015, 33(5): 763-771. DOI: 10.1007/s10118-015-1624-0.
Yi-fei Li, Hai-yang Yu, Hai Sun, 等. Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma[J]. Chinese Journal of Polymer Science, 2015,33(5):763-771. DOI： 10.1007/s10118-015-1624-0.

Yi-fei Li, Hai-yang Yu, Hai Sun, et al. Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma[J]. Chinese Journal of Polymer Science, 2015, 33(5): 763-771. DOI: 10.1007/s10118-015-1624-0. DOI：

摘要

Abstract

Herein

cisplatin-loaded poly(L-glutamic acid)-

-methoxy poly(ethylene glycol) nanoparticles were evaluated as a potential chemotherapeutic agent against osteosarcoma by using alone or with an iRGD (internalizing RGD

CRGDKDPDC). The release rate of platinum from the cisplatin-loaded nanoparticles CDDP/PLG160-

-mPEG2K (CDDP-NPs) accelerated with the increase of the acidity of the environment.

In vitro

test demonstrated that CDDP-NPs could inhibit the proliferation of MNNG/Hos osteosarcoma cells with IC

(72 h) of 12.2 μg×mL

-1

In vivo

test for MNNG/Hos osteosarcoma tumor bearing mice exhibited that CDDP-NPs had comparable or slightly higher efficacy but significantly lower side effects in comparison with free CDDP. The coadministration of iRGD could further enhance the anticancer efficacy of CDDP-NPs against MNNG/Hos osteosarcoma without bringing obvious side effects. Therefore

CDDP-NPs using alone or with iRGD have great potential for the treatment of osteosarcoma.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Synthesis and Properties of Poly(ethylene succinate)-b-poly(butylene carbonate) Multiblock Copolymers

Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

Biodegradable Poly(butylene adipate-co-terephthalate)/Poly(glycolic acid) Films: Effect of Poly(glycolic acid) Crystal on Mechanical and Barrier Properties

Dispersion of Titanium(IV) Oxide Nanoparticles in Mixed Matrix Membrane Using Octaisobutyl Polyhedral Oligomeric Silsesquioxane for Enhanced CO2/CH4 Separation Performance

Experimental Investigation of Graphene and TiO2 Reinforced Poly(vinyl alcohol)-based Fiber Metal Laminates