Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)

Zhi-ming Song; Bo Shi; Jian-xun Ding; Xiu-li Zhuang; Xiao-nan Zhang; Chang-feng Fu; Xue-si Chen

doi:10.1007/s10118-015-1611-5

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Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)

PAPER | Updated：2021-06-21

- Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)
- Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)
- Chinese Journal of Polymer Science 2015年33卷第4期页码：587-596
- Affiliations：
  
  a.Department of Sports Medicine, First Hospital of Jilin University, Changchun 130021, China
  b.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Department of Spine Surgery, First Hospital of Jilin University, Changchun 130021, China
  d.Changchun SinoBiomaterials Co., Ltd., Changchun 130103, China
- Author bio：
  
  **Jian-xun Ding (丁建勋), E-mail: jxding@ciac.ac.cn
  Chang-feng Fu (付长峰), E-mail: 13804312088@163.com
- Funds：
  
  National Natural Science Foundation of China(51303174;51321062;51233004;51390484;51273196;51203153);Scientific Development Program of Jilin Province(20140520050JH)
- DOI：10.1007/s10118-015-1611-5
  中图分类号：
- 收稿：2014-07-25，
  
  修回：2014-10-29，
  
  录用：2014-11-01，
  
  纸质出版：2015-04
- Accepted：
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Zhi-ming Song, Bo Shi, Jian-xun Ding, 等. Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)[J]. Chinese Journal of Polymer Science, 2015,33(4):587-596.

Zhi-ming Song, Bo Shi, Jian-xun Ding, et al. Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)[J]. Chinese Journal of Polymer Science, 2015, 33(4): 587-596. DOI: 10.1007/s10118-015-1611-5.
Zhi-ming Song, Bo Shi, Jian-xun Ding, 等. Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)[J]. Chinese Journal of Polymer Science, 2015,33(4):587-596. DOI： 10.1007/s10118-015-1611-5.

Zhi-ming Song, Bo Shi, Jian-xun Ding, et al. Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)[J]. Chinese Journal of Polymer Science, 2015, 33(4): 587-596. DOI: 10.1007/s10118-015-1611-5. DOI：

摘要

Abstract

An electrospun poly(lactide-

-glycolide) (PLGA) membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments

the membrane showed an appropriate degradation rate

and the pH values of degradation media were maintained at around 7.4. Simultaneously

the excellent biocompatibility of the membrane

in vitro

and

in vivo

was confirmed by live/dead and histopathological analyses. Meanwhile

the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin (H

and Masson's trichrome stainings

and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy

the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.

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