Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride

Ahmed Awadallah-F; Tahia B. Mostafa

doi:10.1007/s10118-015-1591-5

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Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride

PAPER | Updated：2021-06-21

- Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride
- Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride
- Chinese Journal of Polymer Science 2015年33卷第3期页码：376-385
- Affiliations：
  
  a.National Center for Radiation Research and Technology, P.O. Box 29, Nasr City, Cairo, Egypt
  b.Chemistry Department, University College for Women, Ain Shams University, Heliopolis, Cairo, Egypt
- Author bio：
  
  *Ahmed Awadallah-F, E-mail: elsheshengy@yahoo.co.uk
- Funds：
- DOI：10.1007/s10118-015-1591-5
  中图分类号：
- 收稿：2014-05-15，
  
  修回：2014-08-06，
  
  录用：2014-08-14，
  
  纸质出版：2015-03
- Accepted：
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Ahmed Awadallah-F, Tahia B. Mostafa. Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride[J]. Chinese Journal of Polymer Science, 2015,33(3):376-385.

Ahmed Awadallah-F, Tahia B. Mostafa. Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride[J]. Chinese Journal of Polymer Science, 2015, 33(3): 376-385. DOI: 10.1007/s10118-015-1591-5.
Ahmed Awadallah-F, Tahia B. Mostafa. Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride[J]. Chinese Journal of Polymer Science, 2015,33(3):376-385. DOI： 10.1007/s10118-015-1591-5.

Ahmed Awadallah-F, Tahia B. Mostafa. Effect of Functionalized Multi-walled Carbon Nanotubes with Poly(N-vinyl pyrrolidone-co-2-acrylamido-2-methyl-1-propanesulfonic acid) on the Release of Tramadol Hydrochloride[J]. Chinese Journal of Polymer Science, 2015, 33(3): 376-385. DOI: 10.1007/s10118-015-1591-5. DOI：

摘要

Abstract

Multi-walled carbon nanotubes (MWCNTs) were grafted with poly(

-vinyl-2-pyrrolidone) and with poly(2-acrylamido-2-methyl-1-propanesulfonic acid) at different compositions by using

-rays technique as initiator. The MWCNTs

MWCNT-graft-PNVP

MWCNT-graft-PAMPS and MWCNTs-graft-P(NVP-

-AMPS) were characterized by Fourier transform infra red (FTIR) spectroscopy

X-ray diffraction (XRD)

thermal gravimetric analysis (TGA)

elemental analysis and high-resolution transmission electron microscopy (HR-TEM). The results indicated that the grafting processes of PNVP

PAMPS and P(NVP-

-AMPS) occurred on to the surfaces of MWCNTs without destroying the framework of MWCNTs. Tramadol hydrochloride (TH) was loaded as model drug and its release behavior was analyzed

via

various kinetic models. Release of the loaded TH was studied in simulated gastric fluid (SGF

pH = 1.2) and simulated intestinal fluid (SIF

pH = 7.4) at 37 °C. Controlled release of TH from grafted MWCNTs was investigated. The outcome results suggest that the grafted MWCNTs could be used as a promising matrix candidate for oral drug delivery system by harmonization between the composition and pH level of the simulated biological fluids.

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