Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering

Yan-bo Zhang; Jian-xun Ding; Wei-guo Xu; Jie Wu; Fei Chang; Xiu-li Zhuang; Xue-si Chen; Jin-cheng Wang

doi:10.1007/s10118-014-1551-5

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Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering

Updated：2021-06-21

- Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering
- Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering
- Chinese Journal of Polymer Science 2014年32卷第12期页码：1590-1601
- Affiliations：
  
  a.Department of Orthopedics, the Second Hospital of Jilin University, Changchun 130041, China
  b.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Changchun SinoBiomaterials Co., Ltd., Changchun 130103, China
- Author bio：
  
  **Jian-xun Ding (丁建勋), E-mail: jxding@ciac.ac.cn
  Fei Chang (常非), E-mail: ccfei_cn@hotmail.com
  Jin-cheng Wang (王金成), E-mail: jinchengwang@hotmail.com
- Funds：
  
  National Natural Science Foundation of China(81171681;51233004;51273196;51203153;51303174);Scientific Development Program of Jilin Province(20140520050JH)
- DOI：10.1007/s10118-014-1551-5
  中图分类号：
- 收稿：2014-03-05，
  
  修回：2014-04-09，
  
  录用：2014-04-16，
  
  纸质出版：2014-12
- Accepted：
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Yan-bo Zhang, Jian-xun Ding, Wei-guo Xu, 等. Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering[J]. Chinese Journal of Polymer Science, 2014,32(12):1590-1601.

Yan-bo Zhang, Jian-xun Ding, Wei-guo Xu, et al. Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering[J]. Chinese Journal of Polymer Science, 2014, 32(12): 1590-1601.
Yan-bo Zhang, Jian-xun Ding, Wei-guo Xu, 等. Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering[J]. Chinese Journal of Polymer Science, 2014,32(12):1590-1601. DOI： 10.1007/s10118-014-1551-5.

Yan-bo Zhang, Jian-xun Ding, Wei-guo Xu, et al. Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering[J]. Chinese Journal of Polymer Science, 2014, 32(12): 1590-1601. DOI： 10.1007/s10118-014-1551-5.

摘要

Abstract

Poly(lactide-

-glycolide)-poly(ethylene glycol)-poly(lactide-

-glycolide) (PLGA-PEG-PLGA) triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions

and formed hydrogels as the increase of temperature at relatively high concentrations (

15 wt%). The favorable degradability of the hydrogel was confirmed by

in vitro

and

in vivo

degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEG-PLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.

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