Preparation and Characterization of Poly(-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds

Wen Zeng; Wei-kang Hu; Hao Li; Yi-han Jing; Hua Kang; Qing Jiang; Chao Zhang

doi:10.1007/s10118-014-1536-4

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Preparation and Characterization of Poly(-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds

Updated：2021-06-21

- Preparation and Characterization of Poly(-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds
- Preparation and Characterization of Poly(γ-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds
- Chinese Journal of Polymer Science 2014年32卷第11期页码：1507-1514
- Affiliations：
  
  School of Engineering, Sun Yat-sen University, Guangdong 510006, China
- Author bio：
  
  †These authors contribute equally to the work.
  **Chao Zhang (张超), E-mail: zhchao9@mail.sysu.edu.cn
- Funds：
  
  National Natural Science Foundation of China(21004080);Program for New Century Excellent Talents in Universities(NCET-09-0818);Ministry of Education of China, and the Fundamental Research Funds for the Central Universities(101GPY41)
- DOI：10.1007/s10118-014-1536-4
  中图分类号：
- 收稿：2014-01-13，
  
  修回：2014-03-18，
  
  录用：2014-03-24，
  
  纸质出版：2014-11
- Accepted：
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Wen Zeng, Wei-kang Hu, Hao Li, 等. Preparation and Characterization of Poly(-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds[J]. Chinese Journal of Polymer Science, 2014,32(11):1507-1514.

Wen Zeng, Wei-kang Hu, Hao Li, et al. Preparation and Characterization of Poly(γ-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds[J]. Chinese Journal of Polymer Science, 2014, 32(11): 1507-1514. DOI: 10.1007/s10118-014-1536-4.
Wen Zeng, Wei-kang Hu, Hao Li, 等. Preparation and Characterization of Poly(-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds[J]. Chinese Journal of Polymer Science, 2014,32(11):1507-1514. DOI： 10.1007/s10118-014-1536-4.

Wen Zeng, Wei-kang Hu, Hao Li, et al. Preparation and Characterization of Poly(γ-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds[J]. Chinese Journal of Polymer Science, 2014, 32(11): 1507-1514. DOI: 10.1007/s10118-014-1536-4. DOI：

摘要

Abstract

In this paper

methacrylated

-PGA (mPGA) precursor was synthesized

via

reaction between

-PGA and glycidyl methacrylate (GMA). Hydrogels from this precursor were prepared under 365 nm ultraviolet irradiation. The swelling behavior and mechanical properties were studied in detail as functions of the degree of substitution (DS)

precursor concentration

and environmental pH. Results showed that the crosslink density

swelling kinetics and mechanical properties of the hdyrogel could be tailored by adjusting the DS and concentration of the precursor as well as the environmental pH. Three-dimensional photo-encapsulation of swine cartilage chondrocytes and Live/Dead assay proved the cytocompatibility of the hydrogel.

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