Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine

Yan Zhang; Xiao-ju Wang; Miao Guo; Hu-sheng Yan; Chen-hong Wang; Ke-liang Liu

doi:10.1007/s10118-014-1510-1

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Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine

PAPER | Updated：2021-06-21

- Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine
- Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine
- Chinese Journal of Polymer Science 2014年32卷第10期页码：1329-1337
- Affiliations：
  
  Key Laboratory of Functional Polymer Materials (Ministry of Education) and Institute of Polymer Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China
  Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
- Author bio：
  
  **Hu-sheng Yan (阎虎生), E-mail: yanhs@nankai.edu.cn
  Ke-liang Liu (刘克良), E-mail: keliangliu@yahoo.com
- Funds：
  
  National Natural Science Foundation of China(51373080;81001417;20974052);PCSIRT(IRT1257);National Key Technologies R & D Program for New Drugs of China(2009ZX09301-002);Natural Science Foundation of Tianjin Municipality(09JCZDJC22900)
- DOI：10.1007/s10118-014-1510-1
  中图分类号：
- 收稿：2013-12-05，
  
  修回：2014-02-24，
  
  录用：2014-02-27，
  
  纸质出版：2014-10
- Accepted：
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Yan Zhang, Xiao-ju Wang, Miao Guo, 等. Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine[J]. Chinese Journal of Polymer Science, 2014,32(10):1329-1337.

Yan Zhang, Xiao-ju Wang, Miao Guo, et al. Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine[J]. Chinese Journal of Polymer Science, 2014, 32(10): 1329-1337.
Yan Zhang, Xiao-ju Wang, Miao Guo, 等. Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine[J]. Chinese Journal of Polymer Science, 2014,32(10):1329-1337. DOI： 10.1007/s10118-014-1510-1.

Yan Zhang, Xiao-ju Wang, Miao Guo, et al. Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine[J]. Chinese Journal of Polymer Science, 2014, 32(10): 1329-1337. DOI： 10.1007/s10118-014-1510-1.

摘要

Abstract

Multifunctional nanocarriers with multilayer core-shell architecture were prepared by coating superparamagnetic Fe

nanoparticles with diblock copolymer folate-poly(ethylene glycol)-

-poly(glycerol monomethacrylate) (FA-PEG-

-PGMA)

and triblock copolymer methoxy poly(ethylene glycol)-

-poly(2-(dimethylamino) ethyl methacrylate)-

-poly(glycerol monomethacrylate) (MPEG-

-PDMA-

-PGMA). The PGMA segment was attached to the surfaces of Fe

nanoparticles

and the outer PEG shell imparted biocompatibility. In addition

folate was conjugated onto the surfaces of the nanocarriers. Cisplatin was then loaded into the nanocarrier by coordination between the Pt atom in cisplatin and the amine groups in the inner shell of the multilayer architecture. The loaded cisplatin showed pH-responsive release: slower release at pH 7.4 (

i.e.

mimicking the blood environment) and faster release at more acidic pH (

i.e.

mimicking endosome/lysosome conditions). All of the cisplatin-loaded nanoparticles showed concentration-dependent cytotoxicity in HeLa cells. However

the folate-conjugated cisplatin-loaded carriers exhibited higher cytotoxicity in HeLa cells than non-folate conjugated cisplatin-loaded carriers.

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