Synthesis of -Hydroxy-w-Aminotelechelic Polypeptide from -Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides

Hui Peng; Wan-li Chen; Jie Kong; Zhi-quan Shen; Jun Ling

doi:10.1007/s10118-014-1445-6

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Synthesis of -Hydroxy-w-Aminotelechelic Polypeptide from -Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides

Updated：2021-06-21

- Synthesis of -Hydroxy-w-Aminotelechelic Polypeptide from -Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides
- Synthesis of α-Hydroxy-ω-Aminotelechelic Polypeptide from α-Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides
- Chinese Journal of Polymer Science 2014年32卷第6期页码：743-750
- Affiliations：
  
  a.MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  b.Center of Analysis & Measurement, Zhejiang University of Technology, Hangzhou 310014, China
  c.Shaanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an 710072, China
- Author bio：
  
  **Jun Ling (凌君), E-mail: lingjun@zju.edu.cn
- Funds：
  
  National Natural Science Foundation of China(21174122);Special Funds for Major Basic Research Projects(G2011CB606001);Zhejiang Provincial Natural Science Foundation of China(Y4110115)
- DOI：10.1007/s10118-014-1445-6
  中图分类号：
- 收稿：2013-09-03，
  
  修回：2013-11-12，
  
  录用：2013-12-20，
  
  纸质出版：2014-06
- Accepted：
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Hui Peng, Wan-li Chen, Jie Kong, 等. Synthesis of -Hydroxy-w-Aminotelechelic Polypeptide from -Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides[J]. Chinese Journal of Polymer Science, 2014,32(6):743-750.

Hui Peng, Wan-li Chen, Jie Kong, et al. Synthesis of α-Hydroxy-ω-Aminotelechelic Polypeptide from α-Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides[J]. Chinese Journal of Polymer Science, 2014, 32(6): 743-750. DOI: 10.1007/s10118-014-1445-6.
Hui Peng, Wan-li Chen, Jie Kong, 等. Synthesis of -Hydroxy-w-Aminotelechelic Polypeptide from -Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides[J]. Chinese Journal of Polymer Science, 2014,32(6):743-750. DOI： 10.1007/s10118-014-1445-6.

Hui Peng, Wan-li Chen, Jie Kong, et al. Synthesis of α-Hydroxy-ω-Aminotelechelic Polypeptide from α-Amino Acid N-Carboxyanhydrides Catalyzed by Alkali-metal Borohydrides[J]. Chinese Journal of Polymer Science, 2014, 32(6): 743-750. DOI: 10.1007/s10118-014-1445-6. DOI：

摘要

Abstract

It is reported that alkali-metal borohydrides (MBH

M = Li

Na and K) are efficient catalysts for ring opening polymerization (ROP) of

-amino acid

-carboxyanhydrides (NCAs). Polypeptides are prepared in quantitative yields with relatively narrow molecular weight distributions (MWDs = 1.1~1.5) which depend on the reaction temperature. End groups of the produced polypeptide are studied in detail by MALDI-ToF MS

H-NMR

C-NMR

H-

H COSY and

H-

C HMQC analyses. The results indicate that

-hydroxy-

-aminotelechelic polypeptides are formed which are suitable for post-polymerization functionalization.

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