A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer

Fa-ming Gong; Zuo-quan Zhang; Xiao-dong Chen; Lu Zhang; Xing-su Yu; Qi-hua Yang; Xin-tao Shuai; Bi-ling Liang; Du Cheng

doi:10.1007/s10118-014-1399-8

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A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer

Updated：2021-06-21

- A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer
- A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer
- Chinese Journal of Polymer Science 2014年32卷第3期页码：321-332
- Affiliations：
  
  a.PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
  b.Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510630, China
  c.Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China
  d.Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China
- Author bio：
  
  † These authors contributed equally to this work.
  Bi-ling Liang (梁碧玲), E-mail: liangbl@vip.tom.com
  **Du Cheng (程度), E-mail: chengdu@mail.sysu.edu.cn
- Funds：
  
  863 Programs of China(2009AA03Z310);National Natural Science Foundation of China(21174166;30973419);Ph.D. Programs Foundation of Ministry of Education of China(20100171110011);Postdoctoral Foundation(201003370);Natural Science Foundation(9351027501000003;S2011020003140);S&T Programs of Guangdong Province(2010B031500011;2009B030803003;2009B030801107;2012B031800135);SYSU Projects for Promotion of Key and Emerging Interdisciplinary Researches(10ykjc18);Young Teachers(11lgpy44)
- DOI：10.1007/s10118-014-1399-8
  中图分类号：
- 收稿：2013-05-13，
  
  修回：2013-07-26，
  
  录用：2013-08-07，
  
  纸质出版：2014-03
- Accepted：
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Fa-ming Gong, Zuo-quan Zhang, Xiao-dong Chen, 等. A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer[J]. Chinese Journal of Polymer Science, 2014,32(3):321-332.

Fa-ming Gong, Zuo-quan Zhang, Xiao-dong Chen, et al. A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer[J]. Chinese Journal of Polymer Science, 2014, 32(3): 321-332.
Fa-ming Gong, Zuo-quan Zhang, Xiao-dong Chen, 等. A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer[J]. Chinese Journal of Polymer Science, 2014,32(3):321-332. DOI： 10.1007/s10118-014-1399-8.

Fa-ming Gong, Zuo-quan Zhang, Xiao-dong Chen, et al. A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer[J]. Chinese Journal of Polymer Science, 2014, 32(3): 321-332. DOI： 10.1007/s10118-014-1399-8.

摘要

Abstract

Antibody targeted delivery is an effective strategy to improve the diagnostic imaging outcome of nanoscale imaging agents in the focal areas. Dual targeting micelles encapsulating superparamagnetic iron oxide were prepared from the amphiphilic block copolymer poly(ethylene glycol)-poly(ε-caprolactone) (PEG-

-PCL) with different targeting ligands cRGD and scFv-ErbB single chain antibody conjugated to the distal ends of PEG block. The breast cancer animal model was established by subcutaneous injecting the BT474 cells into the BALB/c-nu female nude mice and then employed to assess the potential of the dual ligand targeted magnetic micelles as a novel MRI contrast agent on a 1.5 T clinical MRI scanner. The

signal intensity of the tumor in animals receiving the dual ligand targeted magnetic micelles

via

tail vein decreased more significantly than the single ligand targeted and nontargeted magnetic micelles. These results indicate that the dual ligand targeted magnetic micelles

cRGD/scFv-ErbB-PEG-PCL-SPION

have great potential to act as a new type of effective nanoscale MRI contrast agent for early diagnosis of breast cancer.

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