MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES

Guo-qiang Chen; Yang Wang

doi:10.1007/s10118-013-1280-1

Your Location：

Home >

Browse articles >

MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES

Special Issue: In Honor of the 80th Birthday of Professor Fosong Wang (Part I) | Updated：2023-01-03

- MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES
- MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES
- Chinese Journal of Polymer Science 2013年31卷第5期页码：719-736
- Affiliations：
  
  a.MOE Key Lab of Bioinformatics and Systems Biology, Department of Biological Science and Biotechnology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China
  b.Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China
  c.State Key Laboratory of Plant Physiology and Biochemistry, National Plant Gene Research Centre, College of Biological Sciences, China Agricultural University, Beijing 100193, China
- Author bio：
  
  **Guo-qiang Chen (陈国强), E-mail: chengq@mail.tsinghua.edu.cn
  Yang Wang (汪洋), E-mail: wangy@cau.edu.cn
- Funds：
  
  State Basic Science Foundation 973 project(2012CB725201;2012CB725200)
- DOI：10.1007/s10118-013-1280-1
  中图分类号：
- 收稿：2012-12-31，
  
  修回：2013-01-25，
  
  录用：2013-02-15，
  
  纸质出版：2013-05
- Accepted：
Scan QR Code
Guo-qiang Chen, Yang Wang. MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES[J]. Chinese Journal of Polymer Science, 2013,31(5):719-736.

Guo-qiang Chen, Yang Wang. MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES[J]. Chinese Journal of Polymer Science, 2013, 31(5): 719-736.
Guo-qiang Chen, Yang Wang. MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES[J]. Chinese Journal of Polymer Science, 2013,31(5):719-736. DOI： 10.1007/s10118-013-1280-1.

Guo-qiang Chen, Yang Wang. MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES[J]. Chinese Journal of Polymer Science, 2013, 31(5): 719-736. DOI： 10.1007/s10118-013-1280-1.

摘要

Abstract

Microbial polyhydroxyalkanoates (PHAs) are a family of biopolyesters produced by many wild type and engineered bacteria. PHAs have diverse structures accompanied by flexible thermal and mechanical properties. Combined with their

in vitro

biodegradation

cell and tissue compatibility

PHAs have been studied for medical applications

especially medical implants applications

including heart valve tissue engineering

vascular tissue engineering

bone tissue engineering

cartilage tissue engineering

nerve conduit tissue engineering as well as esophagus tissue engineering. Most studies have been conducted in the authors’ lab in the past 20+ years. Recently

mechanism on PHA promoted tissue regeneration was revealed to relate to cell responses to PHA biodegradation products and cell-material interactions mediated by microRNA. Very importantly

PHA implants were found not to cause carcinogenesis during long-term implantation. Thus

PHAs should have a bright future in biomedical areas.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Advancements and Applications of 4D Bioprinting in Biomedical Science

Fabrication of Highly Anisotropic and Interconnected Porous Scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering

Injectable Hyaluronic Acid/Poly(γ-glutamic acid) Hydrogel with Step-by-step Tunable Properties for Soft Tissue Engineering

Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells

Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction