Magnolol entrapped ultra-fine fibrous mats electrospun from poly(ethylene glycol)-b-poly(L-lactide) and in vitro release

Hao Wang; Hong-rui Song; Yong Cui; Ying-jie Deng; Xue-si Chen

doi:10.1007/s10118-011-1024-z

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Magnolol entrapped ultra-fine fibrous mats electrospun from poly(ethylene glycol)-b-poly(L-lactide) and in vitro release

Paper | Updated：2021-06-21

- Magnolol entrapped ultra-fine fibrous mats electrospun from poly(ethylene glycol)-b-poly(L-lactide) and in vitro release
- MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE
- Chinese Journal of Polymer Science 2011年29卷第2期页码：173-179
- Affiliations：
  
  a.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
  b.School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
  c.School of Life Science and Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
  d.State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
- Author bio：
  
  **Ying-jie Deng (邓英杰), E-mail: dengyingjie45@yahoo.com.cn
  Xue-si Chen (陈学思), E-mail: xschen@ciac.jl.cn
- Funds：
  
  National Natural Science Foundation of China(20274048;50373043);Chinese Academy of Sciences(KJCX2-SW-H07)
- DOI：10.1007/s10118-011-1024-z
  中图分类号：
- 收稿：2010-02-05，
  
  修回：2010-05-04，
  
  录用：2010-05-27，
  
  纸质出版：2011
- Accepted：
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Hao Wang, Hong-rui Song, Yong Cui, 等. Magnolol entrapped ultra-fine fibrous mats electrospun from poly(ethylene glycol)-b-poly(L-lactide) and in vitro release[J]. Chinese Journal of Polymer Science, 2011,29(2):173-179.

Hao Wang, Hong-rui Song, Yong Cui, et al. MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE[J]. Chinese Journal of Polymer Science, 2011, 29(2): 173-179. DOI: 10.1007/s10118-011-1024-z.
Hao Wang, Hong-rui Song, Yong Cui, 等. Magnolol entrapped ultra-fine fibrous mats electrospun from poly(ethylene glycol)-b-poly(L-lactide) and in vitro release[J]. Chinese Journal of Polymer Science, 2011,29(2):173-179. DOI： 10.1007/s10118-011-1024-z.

Hao Wang, Hong-rui Song, Yong Cui, et al. MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE[J]. Chinese Journal of Polymer Science, 2011, 29(2): 173-179. DOI: 10.1007/s10118-011-1024-z. DOI：

摘要

Abstract

Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly(ethylene glycol) blocked poly(L-lactide). Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry. According to

in vitro

drug release investigation by high performance liquid chromatography

it was found that fibers with 10%

20% and 30% drug entrapped respect to polymer (mass ratio) presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K. The reason may be that fibers with 10% drug entrapped was more easily affected by enzyme while

to some degree

magnolol in fibers with 20% and 30% entrapped prevented polymer from being degraded by enzyme.

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