NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT

Zhao-qiang Wu; Shu Yang; Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences; Wuhan University; Wuhan 430072; China

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NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT

Updated：2021-06-21

- NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT
- NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT
- 高分子科学（英文版） 2006年第3期页码：315-321
- Affiliations：
- Author bio：
- Funds：
  
  This work was supported by the National Natural Science Foundation of China （No. 20474044）.()
- DOI：
  中图分类号： O631.3
- 纸质出版：2006
- Accepted：
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[1].NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J].Chinese Journal of Polymer Science,2006(03):315-321.

Zhao-qiang Wu, Shu Yang, Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences, et al. NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J]. 2006, (3): 315-321.
[1].NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J].Chinese Journal of Polymer Science,2006(03):315-321. DOI：

Zhao-qiang Wu, Shu Yang, Wen-yan Liao and Ling-zhi Meng College of Chemistry and Molecular Sciences, et al. NOVEL AMPHIPHILIC FLUORESCENT GRAFT COPOLYMER: SYNTHESIS, CHARACTERIZATION AND ENCAPSULATION OF A HYDROPHOBIC AGENT[J]. 2006, (3): 315-321. DOI：

摘要

<正>Novel amphiphilic fluorescent graft copolymer （PVP-PyAHy） was successfully synthesized by the free radical copolymerization of hydrophobic monomer N-（1-pyrenebutyryl）-N’-acryloyl hydrazide （PyAHy） with hydrophilic precursor polymers of vinyl-functionaiized poly（N-vinylpyrrolidone）（PVP） in DMF. The copolymer is amphiphilic and has intrinsic fluorescence. FT-IR

1H-NMR

TEM

gel permeation chromatography-multi-angle laser light scattering

UV-Vis spectroscopy and fluorescence spectroscopy were used to characterize this copolymer. The TEM observation shows that the copolymer PVP-PyAHy forms micelles in aqueous solution. Results of fluorometric measurements illustrate that the critical micelle concentration （CMC） value of PVP-PyAHy in aqueous solution is about 0.90 mg/mL. To examine the encapsulation ability of the copolymer in aqueous media

methyl yellow was employed as a model hydrophobic agent. The loading level of the polymer to methyl yellow is 8.8 mg/g. The cytotoxicity assays for Madin Darby Canine Kidney （MDCK） cells shows good biocompatibility of PVP-PyAHy in vitro. These results suggest the potential of this copolymer PVP-PyAHy as drugs delivery carrier and fluorescent tracer.

Abstract

Novel amphiphilic fluorescent graft copolymer （PVP-PyAHy） was successfully synthesized by the free radical copolymerization of hydrophobic monomer N-（1-pyrenebutyryl）-N’-acryloyl hydrazide （PyAHy） with hydrophilic precursor polymers of vinyl-functionaiized poly（N-vinylpyrrolidone）（PVP） in DMF. The copolymer is amphiphilic and has intrinsic fluorescence. FT-IR

1H-NMR

TEM

gel permeation chromatography-multi-angle laser light scattering

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