MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES
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MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES
MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES
高分子科学(英文版)2005年23卷第1期 页码:93-102
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纸质出版:2005-01-20
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Jun Zhou, Yong-zhi Qiu, Xiao-peng Zang, 等. MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J]. 高分子科学(英文版), 2005,23(1):93-102.
Jun Zhou, Yong-zhi Qiu, Xiao-peng Zang, et al. MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J]. 2005, 23(1): 93-102.
Jun Zhou, Yong-zhi Qiu, Xiao-peng Zang, 等. MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J]. 高分子科学(英文版), 2005,23(1):93-102.DOI:
Jun Zhou, Yong-zhi Qiu, Xiao-peng Zang, et al. MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J]. 2005, 23(1): 93-102.DOI:
MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES
N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium (DMMCA) was graft-copolymerized onto the surface of segmented poly(ether urethane)(SPEU)and PE film. The carboxybetaine structure on SPEU and PE film surfaces was confirmed by ATR-FTIR
XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro
the two materials studied
including poly-DMMCA gel
all show excellent nonthrombogenicity. This confirms once again that the zwitterionic molecular structure on the surfaces of materials is essential for improving their nonthrombogenicity and biocompatibility.
Abstract
N
N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium (DMMCA) was graft-copolymerized onto the surface of segmented poly(ether urethane)(SPEU)and PE film. The carboxybetaine structure on SPEU and PE film surfaces was confirmed by ATR-FTIR
XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro
the two materials studied
including poly-DMMCA gel
all show excellent nonthrombogenicity. This confirms once again that the zwitterionic molecular structure on the surfaces of materials is essential for improving their nonthrombogenicity and biocompatibility.
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