GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*

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GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*

Papers | Updated：2021-06-21

- GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*
- GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*
- 高分子科学（英文版） 2003年21卷第4期页码：419-425
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- 纸质出版：2003-08-20
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GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*[J]. 高分子科学（英文版）, 2003,21(4):419-425.

GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*[J]. 2003, 21(4): 419-425.
GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*[J]. 高分子科学（英文版）, 2003,21(4):419-425. DOI：

GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*[J]. 2003, 21(4): 419-425. DOI：

摘要

On the molecular level

it is believed that polymers containing zwitterionic structures should be compatible withblood. In this work polyurethane films were grafted with sulfobetaine by a three-step procedure. In the first step

the films'surfaces were treated with hexamethylene diisocyanate (HDI) in toluene at 50℃ in the presence of di-n-butyl tin dilaurate(DBTDL) as a catalyst. The extent of the reaction was monitored by ATR-IR spectra; a maximum number of free NCO groups was obtained after a reaction time of 90 min.In the second step

the hydroxyl groups of N

N-dimethylethanolamine(DMEA) were allowed to react in toluene with NCO groups bound on the surface.In the third step

sulfobetaines were formed on the surface through the ring-opening reaction between tertiary amine of DMEA and 1

3-propanesultone(PS).The surfaces of the films were characterized by ATR-IR and XPS showing that the grafted surfaces were composed of sulfobetaine.The results of the contact angle measurement show that the surface was strongly hydrophilic.The platelet adhesion test demonstrated that the films grafted with sulfobetaine have excellent blood compatibility.

Abstract

On the molecular level

the hydroxyl groups of N

N-dimethylethanolamine(DMEA) were allowed to react in toluene with NCO groups bound on the surface.In the third step

sulfobetaines were formed on the surface through the ring-opening reaction between tertiary amine of DMEA and 1

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