SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES

WANG Zhuting; ZHANG Peiming; SUN Shumen

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SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES

Papers | Updated：2021-06-21

- SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES
- SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES
- 高分子科学（英文版） 1986年4卷第4期页码：359-369
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- 纸质出版：1986-12-20
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WANG Zhuting, ZHANG Peiming, SUN Shumen. SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES[J]. 高分子科学（英文版）, 1986,4(4):359-369.

WANG Zhuting, ZHANG Peiming, SUN Shumen. SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES[J]. 1986, 4(4): 359-369.
WANG Zhuting, ZHANG Peiming, SUN Shumen. SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES[J]. 高分子科学（英文版）, 1986,4(4):359-369. DOI：

WANG Zhuting, ZHANG Peiming, SUN Shumen. SYNTHESIS AND CHARACTERIZATION OF POLYMER DERIVATIVES OF cis-PLATINUM COMPLEXES[J]. 1986, 4(4): 359-369. DOI：

摘要

Cis-platinum complexes used as antitumor drugs were attached onto preformed polymers toreduce the toxicity. Either alternating copolymer of styrene and maleic anhydride (CPSMA) orpolyacrylic acid (PAA) is readily dissolved in alkaline solution. The cis-platinum complexes areeasily converted into water soluble species when treated by silver nitrate in water. The expectedproducts could be obtained when the two aqueous solutions were brought together. The productswere characterized by elementary analysis

IR and XPS.The polymer derivatives could exchange Jigands with nucleophilic groups in biological environment and also exhibit antineoplastic activity.

Abstract

IR and XPS.The polymer derivatives could exchange Jigands with nucleophilic groups in biological environment and also exhibit antineoplastic activity.

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