Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation

Zhi Zhang; Ce-Ce Xue; Ying-Le Feng; Guo-Song Chen

doi:10.1007/s10118-024-3209-2

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Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation

RESEARCH ARTICLE | Updated：2024-11-04

- Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation
- Chinese Journal of Polymer Science Vol. 42, Issue 11, Pages: 1661-1667(2024)
- Affiliations：
  
  a.The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China
  b.School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, China
- Author bio：
  
  fengyingle@snnu.edu.cn (Y.L.F.)
  guosong@fudan.edu.cn (G.S.C.)
- Funds：
- DOI：10.1007/s10118-024-3209-2
  CLC：
- Published：30 November 2024，
  
  Published Online：10 October 2024，
  
  Received：04 July 2024，
  
  Revised：03 August 2024，
  
  Accepted：15 August 2024
- Accepted：
Scan QR Code
Zhang, Z.; Xue, C. C.; Feng, Y. L.; Chen, G. S. Chemical synthesis of globo H and mannobiose glycopolymers and their immunological stimulation. Chinese J. Polym. Sci. 2024, 42, 1661–1667

Zhi Zhang, Ce-Ce Xue, Ying-Le Feng, et al. Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation. [J]. Chinese Journal of Polymer Science, 2024,42(11):1661-1667.
Zhang, Z.; Xue, C. C.; Feng, Y. L.; Chen, G. S. Chemical synthesis of globo H and mannobiose glycopolymers and their immunological stimulation. Chinese J. Polym. Sci. 2024, 42, 1661–1667 DOI： 10.1007/s10118-024-3209-2.

Zhi Zhang, Ce-Ce Xue, Ying-Le Feng, et al. Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation. [J]. Chinese Journal of Polymer Science, 2024,42(11):1661-1667. DOI： 10.1007/s10118-024-3209-2.

摘要

Globo H and mannobiose were synthesized and covalently attached to polymer backbones. Immunological functions of these glyconanoparticles such as stimulation of BMDC to cause upregulation of inflammatory factors were preliminarily explored.

Abstract

Tumor-associated carbohydrate antigens (TACAs) provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy. However

the weak immunogenicity and structural complexity of TACAs are obstacles to their clinical application. Here

based on a fast and low-cost purification strategy for oligosaccharide synthesis

the synthesis of tumour-associated carbohydrate antigens Globo H and mannobiose which resembles repeat unit of mannan was achieved. To enhance the immunogenicity and multivalent effect

Globo H and mannobiose were covalently attached to degradable polymer backbones. 2D spindle-like lamellar micelle and globular micelle were obtained from glycopolymer through a solvent-exchange method of self-assembly. The glyconanoparticle showed good biocompatibility and degradability. Immunological functions of these glyconanoparticles such as stimulation of BMDC to cause upregulation of inflammatory factors were preliminarily explored.

关键词

Keywords

Globo-HMannobioseGlycopolymerConvergent synthesisTumor-associated carbohydrate antigens

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