Triclosan-conjugated, Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

Yan-Qiang Huang; Yuan-Feng Li; Yong Liu; Lin-Qi Shi

doi:10.1007/s10118-024-3094-8

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Triclosan-conjugated, Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

RESEARCH ARTICLE | Updated：2024-05-11

- Triclosan-conjugated, Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms
- Chinese Journal of Polymer Science Vol. 42, Issue 6, Pages: 718-728(2024)
- Affiliations：
  
  a.Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance, Youjiang Medical University for Nationalities, Baise 533000, China
  b.Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China
  c.Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
  d.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
- Author bio：
  
  yanqianghuang@ymun.edu.cn (Y.Q.H)
  y.liu@ucas.ac.cn (Y.L.)
- Funds：
- DOI：10.1007/s10118-024-3094-8
  CLC： M
- Published：1 June 2024，
  
  Published Online：4 March 2024，
  
  Received：18 December 2023，
  
  Revised：10 January 2024，
  
  Accepted：10 January 2024
Scan for full text
Huang, Y. Q.; Li, Y. F.; Liu, Y.; Shi, L. Q. Triclosan-conjugated, lipase-responsive polymeric micelles for eradication of staphylococcal biofilms. Chinese J. Polym. Sci. 2024, 42, 718–728

Yan-Qiang Huang, Yuan-Feng Li, Yong Liu, et al. Triclosan-conjugated, Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms. [J]. Chinese Journal of Polymer Science 42(6):718-728(2024)
Huang, Y. Q.; Li, Y. F.; Liu, Y.; Shi, L. Q. Triclosan-conjugated, lipase-responsive polymeric micelles for eradication of staphylococcal biofilms. Chinese J. Polym. Sci. 2024, 42, 718–728 DOI： 10.1007/s10118-024-3094-8.

Yan-Qiang Huang, Yuan-Feng Li, Yong Liu, et al. Triclosan-conjugated, Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms. [J]. Chinese Journal of Polymer Science 42(6):718-728(2024) DOI： 10.1007/s10118-024-3094-8.

摘要

In this study

we present the introduction of triclosan-conjugated

lipase-responsive polymeric micelles. These micelles are specifically designed to harness the unique properties of biofilms and function as a responsive drug delivery platform. The micelles are formed through the synthesis of an amphiphilic block polymer via ring-opening polymerization of ε-caprolactone (CL) and cyclic trimethylene carbonate (MTC-Tri) containing triclosan.

Abstract

Bacterial biofilms present a significant challenge in treating drug-resistant infections

necessitating the development of innovative nanomedicines. In this study

we introduce triclosan-conjugated

lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery platform. The micelles were created using an amphiphilic block polymer synthesized

via

ring-opening polymerization of

-caprolactone (CL) and triclosan-containing cyclic trimethylene carbonate (MTC-Tri). Poly(ethylene glycol) (PEG-OH) acted as the macro-initiator

resulting in micelles with a PEG shell that facilitated their penetration into bacterial biofilms. An important advantage of our micelles lies in their interaction with local bacterial lipases within biofilms. These lipases triggered rapid micelle degradation

releasing triclosan in a controlled manner. This liberated triclosan effectively eliminated bacteria embedded in the biofilms. Notably

the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts

indicating their biocompatibility and safety. This finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial biofilms. Our triclosan-conjugated

lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial biofilms. By harnessing biofilm properties and implementing a responsive drug delivery system

we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词

Keywords

Self-assemblyPolymer prodrugRing-opening polymerizationBiofilm eradicationCytotoxicity

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