One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of <italic style="font-style: italic">N</italic>-Isopropylacrylamide (NIPAM) in Water

Zi-Shan Li; Jing Lyu; Bei Qiu; Ying-Hao Li; Ruth Foley; Ri-Jian Song; Melissa Johnson; Qiang Geng; Wen-Xin Wang

doi:10.1007/s10118-024-3065-0

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One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water

RAPID COMMUNICATION | Updated：2023-12-26

- One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water
- Chinese Journal of Polymer Science Vol. 42, Issue 1, Pages: 1-6(2024)
- Affiliations：
  
  a.Institute of Precision Medicine (AUST-IPM), Anhui University of Science and Technology, Huainan 232001, China
  b.Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin D04 V1W8, Ireland
- Author bio：
  
  jing.lyu@ucd.ie (J.L.)
  wenxin.wang@ucd.ie (W.X.W.)
- Funds：
- DOI：10.1007/s10118-024-3065-0
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Li, Z. S.; Lyu, J.; Qiu, B.; Li, Y. H.; Foley, R.; Song, R. J.; Johnson, M.; Geng, Q.; Wang, W. X. One-pot and one-step Cu(0)-mediated reversible-deactivation radical polymerization of N-isopropylacrylamide (NIPAM) in water. Chinese J. Polym. Sci. 2024, 42, 1–6

Zi-Shan Li, Jing Lyu, Bei Qiu, et al. One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water. [J]. Chinese Journal of Polymer Science 42(1):1-6(2024)
Li, Z. S.; Lyu, J.; Qiu, B.; Li, Y. H.; Foley, R.; Song, R. J.; Johnson, M.; Geng, Q.; Wang, W. X. One-pot and one-step Cu(0)-mediated reversible-deactivation radical polymerization of N-isopropylacrylamide (NIPAM) in water. Chinese J. Polym. Sci. 2024, 42, 1–6 DOI： 10.1007/s10118-024-3065-0.

Zi-Shan Li, Jing Lyu, Bei Qiu, et al. One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water. [J]. Chinese Journal of Polymer Science 42(1):1-6(2024) DOI： 10.1007/s10118-024-3065-0.

摘要

The well-controlled NIPAM polymerization was realized in water with narrow MWDs and varied MWs via a facile one-pot and one-step Cu(0)-mediated RDRP. Sufficient CuI at the very beginning is the key for kicking off the Cu(0)-mediated NIPAM RDRPs, and adequate deactivation strength during the polymerization process is the key to achieve a well-controlled chain growth.

Abstract

Copper(0)-mediated reversible-deactivation radical polymerization (Cu(0)-mediated RDRP) of the water-soluble monomer ,N,-isopropylacrylamide (NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights (MWs) or complex or multi reaction steps,etc,. In this work, we report the well-controlled polymerization of NIPAM in water ,via, a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu,I, at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator (,i.e., Cu,II,) to the system. Moreover, a low reaction temperature (4 °C) is necessary in the controlled synthesis of higher MW poly(,N,-isopropylacrylamide) (PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature (LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions (MWDs) and varied MWs were successfully achieved.

关键词

Keywords

Cu(0)-mediated RDRPN-isopropylacrylamide PropagationDeactivationReaction parameters

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School of Materials Science and Engineering, Tianjin University

Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4

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State Key Laboratory of Radiation Medicine and Protection, School of Radiological and Interdisciplinary Sciences (RADX), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions

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One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water

DOI：10.1007/s10118-024-3065-0

摘要

Abstract

关键词

Keywords

references