Bioactive Nanomaterials for Cancer Immunotherapy

Zhan-Zhan Zhang; Kai-Jia Liu; Qiu-Shi Li; Yang Liu

doi:10.1007/s10118-026-3567-z

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Bioactive Nanomaterials for Cancer Immunotherapy

Special Topic: Distinguished Young Scholars in Polymer Science | Updated：2026-07-01

- Bioactive Nanomaterials for Cancer Immunotherapy
- Bioactive Nanomaterials for Cancer Immunotherapy
- Chinese Journal of Polymer Science 2026年44卷第7期页码：1984-2001
- Affiliations：
  
  State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, China
- Author bio：
  
  Yliu@nankai.edu.cn
- Funds：
  
  This study was financially supported by the National Natural Science Foundation of China (Nos. 52525310, 52373143, 22077073 and 52203172).;Yang Liu received his Ph.D. in Polymer Chemistry from Nankai University, China (2011) and his second Ph.D. in Chemical Engineering from University of California, Los Angeles, USA (2016). He is currently a full professor at the College of Chemistry, Nankai University. His research focuses on developing novel polymers and nanomaterials to modulate biological processes for the treatment of chronic diseases, cancers, and neurodegenerative diseases.The authors declare no interest conflict.
- DOI：10.1007/s10118-026-3567-z
  中图分类号：
- 收稿：2025-12-30，
  
  录用：2026-01-10，
  
  网络首发：2026-04-24，
  
  纸质出版：2026-07-05
- Accepted：
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Zhang, Z. Z.; Liu, K. J.; Li, Q. S.; Liu, Y. Bioactive nanomaterials for cancer immunotherapy. Chinese J. Polym. Sci. 2026, 44, 1984–2001

Zhan-Zhan Zhang, Kai-Jia Liu, Qiu-Shi Li, et al. Bioactive Nanomaterials for Cancer Immunotherapy[J]. Chinese Journal of Polymer Science, 2026, 44(7): 1984-2001.
Zhang, Z. Z.; Liu, K. J.; Li, Q. S.; Liu, Y. Bioactive nanomaterials for cancer immunotherapy. Chinese J. Polym. Sci. 2026, 44, 1984–2001 DOI： 10.1007/s10118-026-3567-z.

Zhan-Zhan Zhang, Kai-Jia Liu, Qiu-Shi Li, et al. Bioactive Nanomaterials for Cancer Immunotherapy[J]. Chinese Journal of Polymer Science, 2026, 44(7): 1984-2001. DOI： 10.1007/s10118-026-3567-z.

摘要

This review systemically summarizes their studies on bioactive nanomaterials for cancer immunotherapy and highlights three complementary strategies: surface-adaptive nanomaterials to overcome physiological barriers

antigen-engineering nanoplatforms that enhance tumor immunogenicity

and nanomaterials that modulate tumor microenvironment to relieve immune suppression

collectively reinvigorating robust antitumor immune responses.

Abstract

Cancer immunotherapy has revolutionized oncology by harnessing the immune system to recognize and eliminate malignant cells

yet its clinical efficacy is often limited by tumor immune evasion

low immunogenicity

and an immunosuppressive tumor microenvironment (TME). Recent advances in nanotechnology offer opportunities to overcome these barriers by precisely modulating both tumor and immune landscapes. In this review

we summarize three representative strategies developed by our group: (i) surface-adaptive nanomaterials (SANs)

which respond dynamically to physiological and tumor-specific cues to enable prolonged systemic circulation

efficient barrier translocation

and controlled intratumoral activation; (ii) antigen-engineering nanoplatforms

designed to enhance tumor immunogenicity

via

delivering exogenous antigens to antigen-presenting cells (APCs)

inducing tumor cells to re-express or re-generate

or anchoring immunogenic epitopes onto tumor surfaces

thereby promoting T cell activation and converting “cold” tumors into “hot” ones; and (iii) TME-modulating nanomaterials

which alleviate immune suppression

via

targeted delivery of inhibitors

neutralization or degra

dation of suppressive cytokines

and gene-level reprogramming of tumors to restore effector immunity. Together

these approaches provide a multifaceted framework for reinvigorating antitumor immune responses and offer mechanistic insights and design principles for the next generation of bioactive polymeric nanomaterials with potential translational application in cancer immunotherapy.

关键词

Keywords

references

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