An Advanced Hydrogel-based Facial Mask for Skin Quality Testing

Yan-Fang Meng; Yu-Liao Dong; Man-Li Na; Lin Xu

doi:10.1007/s10118-025-3287-9

Your Location：

Home >

Browse articles >

An Advanced Hydrogel-based Facial Mask for Skin Quality Testing

RESEARCH ARTICLE | Updated：2025-02-25

- An Advanced Hydrogel-based Facial Mask for Skin Quality Testing
- An Advanced Hydrogel-based Facial Mask for Skin Quality Testing
- 高分子科学（英文） 2025年43卷第3期页码：495-508
- Affiliations：
  
  a.School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013, China
  b.International Genomics Research Center, Jiangsu University, Zhenjiang 212013, China
- Author bio：
  
  1000003037@ujs.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 52275290 and 51905222), Natural Science Foundation of Jiangsu Province (No. BK20211068), Research Project of State Key Laboratory of Mechanical System and Vibration (No. MSV202419), Major Program of the National Natural Science Foundation of China for Basic Theory and Key Technology of Tri-Co Robots (No. 92248301), the Opening Project of the Key Laboratory of Bionic Engineering (Ministry of Education), Jilin University (No. KF2023006).;Electronic supplementary information (ESI) is available free of charge in the online version of this article at http://doi.org/10.1007/s10118-025-3287-9.
- DOI：10.1007/s10118-025-3287-9
  中图分类号：
- 收稿日期：2024-10-30，
  
  修回日期：2024-12-15，
  
  录用日期：2024-12-17，
  
  网络出版日期：2025-02-13，
  
  纸质出版日期：2025-03-01
- Accepted：
Scan QR Code
Meng, Y. F.; Dong, Y. L.; Na, M. L.; Xu, L. An advanced hydrogel-based facial mask for skin quality testing. Chinese J. Polym. Sci. 2025, 43, 495–508

Yan-Fang Meng, Yu-Liao Dong, Man-Li Na, et al. An Advanced Hydrogel-based Facial Mask for Skin Quality Testing[J]. Chinese journal of polymer science, 2025, 43(3): 495-508.
Meng, Y. F.; Dong, Y. L.; Na, M. L.; Xu, L. An advanced hydrogel-based facial mask for skin quality testing. Chinese J. Polym. Sci. 2025, 43, 495–508 DOI： 10.1007/s10118-025-3287-9.

Yan-Fang Meng, Yu-Liao Dong, Man-Li Na, et al. An Advanced Hydrogel-based Facial Mask for Skin Quality Testing[J]. Chinese journal of polymer science, 2025, 43(3): 495-508. DOI： 10.1007/s10118-025-3287-9.

摘要

To make up the gap/deficiency of unavailable of effective methodologies for real-time assessment of skin quality currently in the market

we have developed an innovative non-toxic

light-activated natural material collagen peptide-lithium chloride hydrogel mask

to effectively distinguishing various skin types.

Abstract

In the event of the ever-increasing growth of the beauty industry and the burgeoning market for facial masks

high-performance and high-safety mask products have emerged. Among these

light-cured collagen peptide-based hydrogels

which are non-toxic

photocurable natural materials

exhibit significant potential for use in facial masks. We developed a novel collagen peptide-lithium chloride hydrogel-based facial mask. Light-cured collagen peptide hydrogel is a non-toxic

light-activated natural material that holds considerable promise for application in facial masks. Nonetheless

there is a significant lack of effective methodologies for real-time assessment of skin quality currently available in the market. To address this deficiency

we have developed an innovative collagen peptide-lithium chloride hydrogel mask

which is characterized by exceptional transparency (98% within the visible spectrum of 400−800 nm)

commendable tensile properties (tensil

e strength of 428.6±2.1 kPa

with a tensile strength increase of 123.9%)

substantial water retention capacity (61%)

and favorable antimicrobial efficacy (89%). The incorporation of lithium chloride enhances ionic conduction at the interface between the human body and hydrogel

thereby enabling quantitative evaluation of skin quality through impedance analysis. Our collagen peptide-lithium chloride hydrogel facial mask demonstrated effectiveness in distinguishing various skin types

including D

(severely dry)

D (mildly to moderately dry)

N (moderate)

O (mildly to moderately oily)

and O

(severely oily). This study presents significant opportunities for the advancement of hydrogel masks and provides a new application platform for polymer hydrogels.

关键词

Keywords

references

Waltz, E. Cosmetics: when biotech is better than nature. Nat. Biotechnol. 2022 , 40 , 626−628..

Bowman, D. M.; van Calster, G.; Friedrichs, S. Nanomaterials and regulation of cosmetics. Nat. Nanotechnol. 2022 , 5 , 92−92..

Xu, X. K.; Guo, L.; Liu, H.; Zhou, Z. X.; Li, S.; Gu, Q. Ding, S. L.; Guo, H. T.; Yan, Y.; Lan, Y. Q.; Li, Q. L.; Wei, W. X.; Zhang, J.; Liu, C.; Su, Y. W. Stretchable electronic facial masks for skin electroporation. Adv. Funct. Mater. 2024 , 34 , 2311144..

Bilgi, E.; Gokce, E. H.; Bayir, E.; Sendemir, A.; Ozer, K. O.; Tuna, E. E. H. Bacterial cellulose based facial mask with Antioxidant property and high moisturizing capacity. Cellulose 2021 , 28 , 10399−10414..

Wang, R.; Li, J. Z.; Chen, W.; Xu, T. T.; Yun, S. F.; Xu, Z.; Xu, Z. Q.; Sato, T.; Chi, B.; Xu, H. A biomimetic mussel-inspired ε -poly-L-lysine hydrogel with robust tissue-anchor and anti-infection capacity. Adv. Funct. Mater. 2017 , 27 , 1604894..

Wang, J.; Sun, Y. M.; Liu, X. Q.; Kang, Y. Y.; Cao, W. B.; Ye, J.; Gao, C. Y. An antibacterial and anti-oxidant hydrogel containing hyperbranched poly-L-lysine and tea polyphenolsaccelerates healing of infected wound. Biomater. Adv. 2024 , 157 , 213755..

Chen, J. L.; Cai, Z. Y.; Wei, Q. R.; Wang, D.; Wu, J.; Tan, Y. F.; Lua, J.; Ai, H. Proanthocyanidin-crosslinked collagen/konjac glucomannan hydrogel with improved mechanical properties and MRI trackable biodegradation for potential tissue engineering scaffolds. J. Mater. Chem. 2020 , 8 , 316−331.

Du, Y. Z.; Fan, D. D.; Ma, X. X.; Zhu, C. H. Zhang, L. J. Study the biodegradation of an injection human-like collagen hydrogel. Adv. Eng. Mater. 2012 , 535 , 2291−2295..

You, D. G.; Jung, J. M.; Kim, C. H.; An, J. Y.; Bui, V. D.; Lee, J. M.; Um, W.; Jo, D. G.; Cho, Y. W.; Lee, D. S.; Balaj, L.; Lee, H.; Park, J. H. Stem cell-derived extracellular vesicle-bearing injectable hydrogel for collagen generation in dermis. ACS Appl. Mater. Interfaces 2024 , 16 , 37698−37706..

Wang, Q.; Yan, H. Y.; Zhang, J. T.; Tian, X. Y.; Xiao, J. X. Engineering a durable BDDE cross-linked collagen filler for skin rejuvenation. Biomedical. Mater. 2024 , 19 , 055021..

Yang, G. W.; Chen, X. Y.; Shi, W. J.; Chen, N.; Liu, Y.; Zhang, B.; Shao, Z. Z. Facile preparation of a photo-cross-linked silk fibroin-poly ionic liquid hydrogel with anti-freezing and ion conductive properties. ACS Appl. Mater. Interfaces 2024 , 16 , 1543−1552..

Oh, J. J.; Ammu, S.; Vriend, V. D.; Kieffer, R.; Kleiner, F. H.; Balasubramanian, S.; Karana, E.; Masania, K.; Aubin-Tam, M. E. Growth, distribution, and photosynthesis of Chlamydomonas Reinhardtii in 3D hydrogels. Adv. Mater. 2024 , 36 , 2305505..

Zhou, C.; Li, P.; Qi, X.;Sharif, A. R. M.; Poon, Y. F.; Cao, Y.; Chang, M. W.; Leong, S. S. J.; Chan-Park, M. B. A photo-polymerized antimicrobial hydrogel coating derived from ε -poly-L-lysine. Biomaterials 2011 , 32 , 2704−2712..

Meng, Y. W.; Niu, Y. Q.; Ye, C. D.; He, X. F.; Meng, L. F.; Zhang, Z. X.; Hsu, K. C.; Lin, X. R.; Andrew, S.; Zhang, X. H.; Frederic, F.; Wu, Y. Efficacy of a moisturizing cream and Facial mask for alleviating skin problems associated with medical mask use: a half-face, randomized controlled study. J. Cosmet. Dermatol. 2024 , 23 , 2097−2102..

Li, S.; Xu, J. W.; Li, R.; Wang, Y. K.; Zhang, M. Y.; Li, J.; Yin, S. Z.; Liu, G. D.; Zhang, L. J.; Li, B. Q.; Gu, Q. Y.; Su. W. Stretchable electronic facial masks for sonophoresis. ACS Nano 2022 , 16 , 5961−5974..

Xiao, M.; Tan, M.; Peng, C.; Jiang, F.; Wu, K.; Liu, N.; Li, D.; Yao, X. L. Soft and flexible polyvinyl alcohol/pullulan aerogels with fast and high water absorption capacity for facial mask substrates. Int. J. Biol. Macromol. 2024 , 264 , 130469..

Xia, K. Q.; Xu, Z. W. Applying a triboelectric nanogenerator by using facial mask for flexible touch sensor applying a triboelectric nanogenerator by using facial mask for flexible touch sensor. Sens. Actuator. B-Chem. 2021 , 331 , 112710..

Eg awa, M.; Oguri, M.; Hirao, T.; Takahashi, M.; Miyakawa, M. The evaluation of skin friction using a frictional feel analyzer. Skin Res. Technol. 2002 , 8 , 41−51..

Corcuff, P.; Lev´ eque, J. L. Skin surface replica image, in: J. Serup, ˆ G.B.E. Jemec (Eds.), Analysis of Furrows and Wrinkles: Handbook of Non-Invasive Methods and the Skin , CRC Press 1995 , 89−96..

Makki, S.; Mignot, J.; Zahouani, H. Statistical analysis of the skin surface and three dimensional representation of human skin. J. Soc. Cosmet. Chem. 1985 , 35 , 311−317..

Romano, R. A.; Rosa, R. G. T.; Salvio, A. G.; Jo, J. A.; Kurachi, C. Multispectral autofluorescence dermoscope for skin lesion assessment. Photodiagn. Photodyn. Therapy 2020 , 30 , 101704.

Kyritsis, A.; Pissis, P.; Grammatikakis, J. Dielectric relaxation spectroscopy in poly(hydroxyethyl acrylates)/water hydrogels. J. Polym. Sci., Part B: Polym. Phys. 1995 , 33 , 1737−1750..

Zhang, D. B.; Zhang, M. Y.; Wang, J. W.; Sun , H. L.; Liu, H.; Mi, L. W.; Liu, C. T.; Shen, C. Y. Impedance response behavior and mechanism study of Axon-like Ionic conductive cellulose-based hydrogel strain sensor. Adv. Compos. Hybrid. Mater. 2022 , 5 , 1812−1820..

Okutan, M.;Yavuz, E.; Özerol, E. A.; Şenkal, B. F.; Yalçın, O.; Yıldız, A. Impedance spectroscopy of Polyaniline coated hydrogel. Polym. Bull. 2021 , 78 , 4473−4486..

Sosa, M.; Bernal-Alvarado, J.; Jiménez-Moreno, M.; Hernández, J. C.; Gutiérrez-Juárez, G.; Vargas-Luna, M.; Huerta, M.; Villagómez Castro, J. C.; Palomares, P. Magnetic field influence on electrical properties of human Blood measured by impedance spectroscopy. Bioelectromagnetics 2005 , 26 , 564−570..

Burton, C. E.; Burton, W. M.; Akers, L. A. The application of bode analysis to skin impedance. Psychophysiology 1974 , 11 , 517..

Hernández, F.; Salazar, C. A.; Bernal, J. J. Determinación de laspropied ade seléctrica sentejido sanguíneo. Ciencia U. ANL. 2007 , 510 , 51525..

Mech-Dorosz, A.; Khan, M. S.; Mateiu, R. V.; Hélix-Nielsen, C.; Emnéus, J.; Heiskanen, A. Impedance characterization of biocompatible hydrogel suitable for Biomimetic lipid membrane applications. Electrochimica. Acta 2021 , 373 , 137917..

Cai, W.; Xie, S. B.; Zhang, J.; Tang, D.; Tang, Y. An electrochemical impedance biosensor for Hg 2+ detection based on DNA hydrogel by coupling with DNA-enzyme-assisted target recycling and hybridization chain reaction. Biosens. Bioelectron. 2017 , 98 , 466−472..

Turo, F. D.; Matricardi, P.; Meo, C. D.; Mazzei, F.; Favero, G.; Zane, D. PVA hydrogel as polymer electrolyte for electrochemical impedance analysis on archaeological metals. J. Cult. Herit. 2019 , 37 , 113−120..

Chen, H. F.; Yang, X.; Geng, J. L.; Ma, G.; Wang, X. A skin-like hydrogel for distributed force sensing using an electrical impedance tomography-based 29 pseudo-array method. ACS Appl. Electron. Mater. 2023 , 5 , 1451−1460..

Lou, D. Y.; Wang, C. S.; He, Z. Y.; Sun, X. Y.; Luo, J. S.; Li, J. Robust organohydrogel with flexibility and conductivity across the Freezing and Boiling temperatures of water. Chem. Commun. 2019 , 55 , 8422−8425..

Autelitano, F.; Longo, S. Felice Giuliani Phyto-based sodium chloride hydrogel for highway winter maintenance of porous asphalt pavements. Cons. Build. Mater. 2022 , 319 , 126082..

Tanveer, S.; Chen, C. C. Thermodynamic analysis of hydrogel swelling in aqueous sodium chloride solutions. J. Mol. Liq. 2022 , 348 , 118421..

Lia, Y.; Hea, J. T.; Lyua, X. L.; Yuana, Y.; Wang, C. Z.; Zhao, B. H. Chitosan-based thermosensitive hydrogel for nasal delivery of exenatide: effect of magnesium chloride. Inter. J. Pharm. 2018 , 553 , 375−385.

De Mello Innocentini, M. D.; Bueno, B. R. F.; Urbas, A.; Microstructural, A. M. C. Fluid dynamic, and mechanical characterization of zinc oxide and magnesium chloride-modified hydrogel scaffolds. ACS Biomater. Sci. Eng. 2024 , 10 , 4791−4801..

Choi, CW; Choi, J. W.; Youn, S. W. Subjective facial skin type, based on the sebum related symptoms, can reflect the objective casual sebum level in acne patients. Skin Res. Technol. 2012 , 19 , 176−182..

Dawson, J. B.; Barker D. J.; Ellis, D. J. A theoretical and experimental study of light absorption and scattering by in vivo skin. Phys. Med. Biol. 2000 , 25 , 695−709..

Lee, E. S. Satisfaction and management attitude for skin according to age and skin type. Asian J. Beaut. Cosmetol. 2011 , 9 , 1−11..

Nguyen, K. D.; Kobayashi, T. Chitin hydrogels prepared at various lithium chloride/ N,N -dimethylacetamide solutions by water vapor-induced phase inversion. J. Chem. 2020 , 12 , 6645351..

Wen, Z.; Xin, C.; Zhong, S. Infrared and Raman spectroscopy for the study of filament protein conformation. Adv. Chem. 2006 , 18 , 1514−1522..

Sun, T. L.; Kurokawa, T.; Kuroda, S.; Ihsan, A. B.; Akasaki, T.; Sato, K.; Haque, Md. A.; T. Nakajima, T.; Gong, J. P. Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity. Nat. Mater. 2013 , 12 , 932−937..

Lodge, T P.; Mcleish, T. C. Self-concentrations and effective glass transition temperatures in polymer blends. Macromolecules 2000 , 33 , 5278−5284..

Lipson, J. E.; Milner, S. T. Multiple glass transitions and local composition effects on polymer solvent mixtures. J. Polym. Sci., Part B: Polym. Phys. 2006 , 44 , 3528−3545..

Pek, Y. S.; Wan, A. C. A.; Ying, J. Y. The effect of matrix stiffness on mesenchymal stem cell differentiation in a 3D thixotropic gel. Biomaterials 2010 , 31 , 385−391..

Ehrbar, M.; Sala, A.; Lienemann, P.; Ranga, A.; Mosiewicz, K.; Bittermann, A.; Rizzi, S. C.; Weber, F. E.; Lutolf, M. P. Elucidating the role of matrix stiffness in 3d cell migration and remodeling. Biophys. J. 2011 , 100 , 284−293..

Hamdaoui, L.; Bouchti, M.; Moussaouiti, M. Comparison of rheological pro-perties of kraft and microcrystalline cellulose dissolved in lithium chloride/ N,N -dimethylacetamide. Polym. Bull. 2018 , 75 , 769−779..

Li, L. L.; Wang, X. W.; Gao, S.; Zheng, S. J.; Zou, X. Y.; Xiong, J. F.; Li, W. Z.; Yan, F. High-toughness and high-strength solvent-free linear poly(ionic liquid) elastomers. Adv. Mater. 2024 , 36 , 2308547..

Wang, Y. M.; Huang, F.; Chen, X. B; Wang, X. W.; Zhang, W. B.; Peng, J.; Li, J. Q.; Zhai, M. L. Stretchable, conductive, and self-healing hydrogel with super metal adhesion. Chem. Mater. 2018 , 30 , 4289−4297..

Gu, T. R.; Li, W. L.; Ma, J.; Dai, M.; Cheng, H. M. in Surface Chemistry , Beijing Chemical Industry, 1994 , 15..

Janting, J.; Pedersen, J. K. M.; Woyess, A. G.; Nielsen, K.; Bang, O. Small and robust all-polymer fiber Bragg grating based pH sensor. J- LT . 2019 , 37 , 4480-4486..

Dorf, R. C.; Svoboda, J. A. in Introduction to Electric Circuits , Wiley, 2009 ..

Cahan, B. D.; Wainright, J. S. AC impedance investig ations of proton conduction in Nafion. J. Electrochem. Soc. 1993 , 140 , 185−186..

Hekstra, D. R.; White, K. I.; Socolich, M. A.; Henning, R. W.; Srajer, V.; Ranganathan, R. Electric-field-stimulated protein mechanics. Natrue 2016 , 540 , 400−405..

Moroni, A.; Varde, C.; Giustetto, A.; Stagi, S.; Marini, E.; Cremasco, M. M. Bioelectrical impedance vector analysis (BIVA) for the monitoring of body composition in pregnancy. Eur. J. Clin. Nutr. 2022 , 76 , 604−609..

Rusua, C.; Krozera, A.; Johanssona, C.; Ahrentorpa, F.; Petterssona, T.; Christian Jonassona, C.; Rösevalla, J.; Ilvera, D.; Terzaghib, M.; Chiatanteb, D.; Montagnoli, A. Miniaturized wireless water content and Conductivity soil sensor system. Comput. Electron. Agr. 2019 , 167 , 10507..

Yoshino, T.; Shimojuku A. Li, D. Electrical conductivity of Stishovite as a function of water content. Phys. Earth. Planet. In. 2014 , 227 , 48−54..

Mahdavian, M.; Attar, M. M. Another approach in analysis of paint coatings with EIS meas urement: phase angle at high frequencies. Corros. Sci. 2006 , 48 , 4152−4157..

Touzain, S. Some comments on the use of the EIS phase angle to evaluate organic coating degradation. Electrochim. Acta 2010 , 55 , 6190−6194..

Peng, Z.Y.; Peng, Z. P.; Shen, Y. Q. Study on biological safety of polyvinyl alcohol/collagen hydrogel as a tissue substitute (II). JMS-PAC. 2011 , 48 , 632−636..

Firooz, A.; Sadr, B.; Babakoohi, S. Variation of biophysical parameters of the skin with age, gender, and body region. Sci. World J. 2012 , 6 , 386936..

Kikuchi, K; Kobayashi, H; Le, F. The winter season affects more severely the facial skin than the forearm skin: comparative biophysical studies conducted in the same japanese females in later summer and winter. Exogenous Dermatology 2002 , 1 , 32−38..

Lee, J. H.; Heo, S.; Kim, Y. J.; Eom, J.; H. J. Jung, H. Kim, J. W.; Kim, I.; Park, H. H.; Mo, H. S.; Kim, Y. H.; Park, S. K. A behavior-learned cross-rea ctive sensor matrix for intelligent skin perception. Adv. Mater. 2020 , 32 , 2000969..

Polat, B.; Polat, L. L.; Hsu, P. Y.; Kaipu, V.; Mercier, P. P.; Cheng, C. K.; Lipomi, D. J. ACS Appl. Nano Mater . 2021 , 4, 8126..

Jiang, Y.; Sadeqi, A.; Miller, E. L.; Sonkusale, S. Head motion classification using thread-based sensor and machine learning algorithm. Sci. Rep. 2021 , 11 , 2646..

Shin, H.; Oh, S.; Hong, S.; Kang, M.; Kang, D.; Ji, Y.; Choi, B. H.; Kang, K.; Jeong, H.; Park, Y.; Hong, S.; Kim, H. K.; Choi, Y. Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes. ACS Nano 2020 , 14 , 5435−5444..

Swift, A.; Liew, S.; Weinkle S.; Garcia, J. K.; Silberberg, M. B. The facial aging process from the "inside out" (OUP). Aesthet. Surg. J. 2021 , 41 , 1107−1119..

Cho, C.; Lee, E.; Park, G.; Cho, E.; Kim, N.; Shin, J.; Woo, S.; Ha, J.; Hwang, J. Evaluation of f acial skin age based on biophysical properties in vivo. J. Cosmet. Dermatal . 2022 , 21 , 3546-3554..

Flament, F.; Prunel, A.; Keufer, B. Changes in Facial signs due to age and their respective weights on the perception of age and skin plumpness among different aged Koreaan women. Skin Res. Technol. 2021 , 4 , 526−536.

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Photoswitchable Spiropyridine Enabled Photoactuation of Polymeric Hydrogels under Physiological pH Conditions