Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves

Zi-Lin Wang; Di Huang; Mei-Yu Zhang; Xin-Xin Fu; Ying Luo; Lei Zou; Si-Jia Gao; Zhuo Zhao; Ya-Fei Wang; Yan Zhang; Yong-Jun Zhang

doi:10.1007/s10118-023-2995-2

Your Location：

Home >

Browse articles >

Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves

RESEARCH ARTICLE | Updated：2023-09-21

- Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves
- Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves
- 高分子科学（英文版） 2023年41卷第10期页码：1646-1655
- Affiliations：
  
  a.State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tiangong University, Tianjin 300387, China
  b.Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Center Hospital, Tianjin 300170, China
  c.School of Chemistry, Tiangong University, Tianjin 300387, China
- Author bio：
  
  zoulei@tiangong.edu.cn (L.Z.)
  zhangyj@tiangong.edu.cn (Y.J.Z.)
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China (Nos. 22275137 and 82202342) and Natural Science Foundation of Tianjin Municipal Science and Technology Commission (No. 21JCYBJC01810).
- DOI：10.1007/s10118-023-2995-2
  中图分类号：
- 收稿：2023-03-22，
  
  修回：2023-4-23，
  
  录用：2023-4-25，
  
  网络首发：2023-06-12，
  
  纸质出版：2023-10-01
- Accepted：
Scan QR Code
Wang, Z. L.; Huang, D.; Zhang, M. Y.; Fu, X. X.; Luo, Y.; Zou, L.; Gao, S. J.; Zhao, Z.; Wang, Y. F.; Zhang, Y.; Zhang, Y. J. Responsive hybrid poly(vinyl alcohol) hydrogel membranes with embedded microgels as valves. Chinese J. Polym. Sci. 2023, 41, 1646–1655

Zi-Lin Wang, Di Huang, Mei-Yu Zhang, et al. Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves[J]. Chinese Journal of Polymer Science, 2023, 41(10): 1646-1655.
Wang, Z. L.; Huang, D.; Zhang, M. Y.; Fu, X. X.; Luo, Y.; Zou, L.; Gao, S. J.; Zhao, Z.; Wang, Y. F.; Zhang, Y.; Zhang, Y. J. Responsive hybrid poly(vinyl alcohol) hydrogel membranes with embedded microgels as valves. Chinese J. Polym. Sci. 2023, 41, 1646–1655 DOI： 10.1007/s10118-023-2995-2.

Zi-Lin Wang, Di Huang, Mei-Yu Zhang, et al. Responsive Hybrid Poly(vinyl alcohol) Hydrogel Membranes with Embedded Microgels as Valves[J]. Chinese Journal of Polymer Science, 2023, 41(10): 1646-1655. DOI： 10.1007/s10118-023-2995-2.

摘要

Poly(vinyl alcohol) hydrogel hybrid membranes with embedded poly(Nisopropylacrylamide-acrylic acid) microgels were constructed by simple mixing and subsequent freezing-thawing process. The temperature and pH responsiveness of the P(NIPAM-AA) microgels in the membranes matrix were retained and the obtained hydrogel membranes exhibited extraordinary responsiveness to temperature and pH

with microgels functioning as the responsive valves.

Abstract

The research and application of responsive materials have long been hampered by their complicated designs and tedious construction processes. Besides

many current responsive materials show retard or weak responsiveness. In this study

responsive hybrid poly(vinyl alcohol) hydrogel membranes with embedded poly(

-isopropylacrylamide-acrylic acid) microgels as valves were constructed by simple mixing and subsequent freezing-thawing process. In the structure of the membranes

the matrix poly(vinyl alcohol) chains thread through and entangle with the microgels

and the microgels are firmly constrained within the hybrid hydrogel network. The fast and sharp temperature responsiveness of the embedded microgels was largely retained and endowed the hydrogel membrane with excellent temperature and pH responsiveness. Moreover

the hydrogel membrane showed excellent fatigue resistance in both temperature and pH-responsive flux examination. This study presented the great potential of these hybrid hydrogel membranes in biomedical applications and provided a new strategy for the future design and construction of responsive biomaterials.

关键词

Keywords

references

Yazdi,M.K.;Vatanpour,V.;Taghizadeh,A.;Taghizadeh,M.;Ganjali,M.R.;Munir,M.T.;Habibzadeh,S.;Saeb,M.R.;Ghaedi,M.Hydrogelmembranes:areview. Mater. Sci. Eng., C 2020 , 114 ,111023..

Teodorescu,M.;Bercea,M.;Morariu,S.BiomaterialsofPVAandPVPinmedicalandpharmaceuticalapplications:perspectivesandchallenges. Biotechnol. Adv. 2019 , 37 ,109−131..

Aslam,M.;Kalyar,M.A.;Raza,Z.A.Polyvinylalcohol:areviewofresearchstatusanduseofpolyvinylalcoholbasednanocomposites. Polym. Eng. Sci. 2018 , 58 ,2119−2132..

Wu,S.;Hua,M.;Alsaid,Y.;Du,Y.;Ma,Y.;Zhao,Y.;Lo,C.-Y.;Wang,C.;Wu,D.;Yao,B.;Strzalka,J.;Zhou,H.;Zhu,X.;He,X.Poly(vinylalcohol)hydrogelswithbroad-rangetunablemechanicalproperties via theHofmeistereffect. Adv. Mater. 2021 , 31 ,2007829..

Hua,M.;Wu,S.;Ma,Y.;Zhao,Y.;Chen,Z.;Frenkel,I.;Strzalka,J.;Zhou,H.;Zhu,X.;He,X.Strongtoughhydrogels via thesynergyoffreeze-castingandsaltingout. Nature 2021 , 590 ,594−599..

Bodugoz-Senturk,H.;Macias,C.E.;Kung,J.H.;Muratoglu,O.K.Poly(vinylalcohol)-acrylamidehydrogelsasload-bearingcartilagesubstitute. Biomaterials 2009 , 30 ,589−596..

Xu,L.;Qiao,Y.;Qiu,D.Coordinativelystiffenandtoughenhydrogelswithadaptablecrystal-domaincross-linking. Adv. Mater. 2022 , 32 ,2209913..

Zhao,Y.;Cui,Z.;Liu,B.;Xiang,J.;Qiu,D.;Tian,Y.;Qu,X.;Yang,Z.Aninjectablestronghydrogelforbonereconstruction. Adv. Health. Mater. 2019 , 8 ,1900709..

Xu,L.;Qiu,D.Reversibleswitchingofpolymericgelstructureandpropertybysolventexchange. Sci. China Mater. 2022 , 65 ,547−552..

Xu,L.;Gao,S.;Guo,Q.;Wang,C.;Qiao,Y.;Qiu,D.Asolvent-exchangestrategytoregulatenoncovalentinteractionsforstrongandantiswellinghydrogels. Adv. Mater. 2020 , 32 ,2004579..

Hao,M.;Wang,Y.;Li,L.;Liu,Y.;Bai,Y.;Zhou,W.;Lu,Q.;Sun,F.;Li,L.;Feng,S.;Wei,W.;Zhang,T.Toughengineeringhydrogelsbasedonswelling-freeze-thawmethodforartificialcartilage. ACS Appl. Mater. Interfaces 2022 , 14 ,25093−25103..

ElNemr,A.;Serag,E.;El-Maghraby,A.;Fathy,S.A.;AbdelHamid,F.F.ManufacturingofpHsensitivePVA/PVP/MWCNTandPVA/PEG/MWCNTnanocomposites:anapproachforsignificantdrugrelease. J. Macromol. Sci. A 2019 , 56 ,781−793..

Feiz,S.;Navarchian,A.H.;Jazani,O.M.Poly(vinylalcohol)membranesinwound-dressingapplication:microstructure,physicalproperties,anddrugreleasebehavior. Iran. Polym. J. 2018 , 27 ,193−205..

Gao,B.;Konno,T.;Ishihara,K.Fabricationofalivecell-containingmultilayeredpolymerhydrogelmembranewithmicrometer-scalethicknesstoevaluatepharmaceuticalactivity. J. Biomater. Sci., Polym. Ed. 2015 , 26 ,1372−1385..

Górska,A.;Krupa,A.;Majda,D.;Kulinowski,P.;Kurek,M.;Węglarz,W.P.;Jachowicz,R.Poly(vinylalcohol)cryogelmembranesloadedwithresveratrolaspotentialactivewounddressings. AAPS PharmSciTech 2021 , 22 ,109..

Feiz,S.;Navarchian,A.H.Poly(vinylalcohol)hydrogel/chitosan-modifiedclaynanocompositesforwounddressingapplicationandcontrolleddrugrelease. Macromol. Res. 2019 , 27 ,290−300..

Kamoun,E.A.;Kenawy,E.-R.S.;Chen,X.Areviewonpolymerichydrogelmembranesforwounddressingapplications:PVA-basedhydrogeldressings. J. Adv. Res. 2017 , 8 ,217−233..

Ghobril,C.;Grinstaff,M.W.Thechemistryandengineeringofpolymerichydrogeladhesivesforwoundclosure:atutorial. Chem. Soc. Rev. 2015 , 44 ,1820−1835..

Lima,T.deP.deL.;Passos,M.F.Skinwounds,thehealingprocess,andhydrogel-basedwounddressings:ashortreview. J. Biomater. Sci., Polym. Ed. 2021 , 32 ,1910−1925..

Gudeman,L.F.;Peppas,N.A.pH-sensitivemembranesfrompoly(vinylalcohol)/poly(acrylicacid)interpenetratingnetworks . J. Membr. Sci. 1995 ,107,239-248..

Hickey,A.S.;Peppas,N.A.Meshsizeanddiffusivecharacteristicsofsemicrystallinepoly(vinylalcohol)membranespreparedbyfreezing/thawingtechniques. J. Membr. Sci. 1995 , 107 ,229−237..

Liu,H.W.;Hu,S.H.;Chen,Y.W.;Chen,S.Y.Characterizationanddrugreleasebehaviorofhighlyresponsivechip-likeelectricallymodulatedreducedgrapheneoxide-poly(vinylalcohol)membranes. J. Mater. Chem. 2012 , 22 ,17311−17320..

Kamoun,E.A.;Kenawy,E.R.S.;Tamer,T.M.;El-Meligy,M.A.;MohyEldin,M.S.Poly(vinylalcohol)-alginatephysicallycrosslinkedhydrogelmembranesforwounddressingapplications:characterizationandbio-evaluation. Arab. J. Chem. 2015 , 8 ,38−47..

Li,Z.;Zhou,Y.;Li,T.;Zhang,J.;Tian,H.Stimuli-responsivehydrogels:fabricationandbiomedicalapplications. VIEW 2022 , 3 ,20200112..

Gopishetty,V.;Tokarev,I.;Minko,S.Biocompatiblestimuli-responsivehydrogelporousmembranes via phaseseparationofapolyvinylalcoholandNa-alginateintermolecularcomplex. J. Mater. Chem. 2012 , 22 ,19482−19487..

Lavine,B.K.;Kaval,N.;Oxenford,L.;Kim,M.;Dahal,K.S.;Perera,N.;Seitz,R.;Moulton,J.T.;Bunce,R.A.Synthesisandcharacterizationof N -isopropylacrylamidemicrospheresaspHsensors. Sensors 2021 , 21 ,6493..

Lu,Y.;Aimetti,A.A.;Langer,R.;Gu,Z.Bioresponsivematerials. Nat. Rev. Mater. 2016 , 2 ,16075..

Tanaka,T.;Fillmore,D.J.Kineticsofswellingofgels. J. Chem. Phys. 1979 , 70 ,1214−1218..

Sun,J.Y.;Zhao,X.;Illeperuma,W.R.K.;Chaudhuri,O.;Oh,K.H.;Mooney,D.J.;Vlassak,J.J.;Suo,Z.Highlystretchableandtoughhydrogels. Nature 2012 , 489 ,133−136..

Willcox,P.J.;HowieJr.,D.W.;Schmidt-Rohr,K.;Hoagland,D.A.;Gido,S.P.;Pudjijanto,S.;Kleiner,L.W.;Venkatraman,S.Microstructureofpoly(vinylalcohol)hydrogelsproducedbyfreeze/thawcycling. J. Polym. Sci., Part B: Polym. Phys. 1999 , 37 ,3438−3454..

Guan,Y.;Zhang,Y.PNIPAMmicrogelsforbiomedicalapplications:fromdispersedparticlesto3Dassemblies. Soft Matter 2011 , 7 ,6375−6384..

Wang,J.;Gan,D.;Lyon,L.A.;El-Sayed,M.A.Temperature-jumpinvestigationsofthekineticsofhydrogelnanoparticlevolumephasetransitions. J. Am. Chem. Soc. 2001 , 123 ,11284−11289..

Joshi,R.G.;Karthickeyan,D.;Gupta,D.K.;Tata,B.V.R.Effectofentanglementsontemperatureresponseofgelimmobilizedmicrogelphotoniccrystals. Colloids Surf., A 2018 , 558 ,600−607..

Song,W.;Guan,Y.;Zhang,Y.;Zhu,X.X.Mutualinteractionbetweenembeddedmicrogelparticlesandthesurroundinghydrogelmatrix. Soft Matter 2013 , 9 ,2629−2636..

Lynch,I.;Dawson,K.A.Releaseofmodelcompoundsfrom“plum-pudding”-typegelscomposedofmicrogelparticlesrandomlydispersedinagelmatrix. J. Phys. Chem. B 2004 , 108 ,10893−10898..

Lynch,I.;deGregorio,P.;Dawson,K.A.Simultaneousreleaseofhydrophobicandcationicsolutesfromthin-film“plum-pudding”gels: amultifunctionalplatformforsurfacedrugdelivery. J. Phys. Chem. B 2005 , 109 ,6257−6261..

Lynch,I.;Dawson,K.A.Synthesisandcharacterizationofanextremelyversatilestructuralmotifcalledthe“plum-pudding”gel. J. Phys. Chem. B 2003 , 107 ,9629−9637..

Lutz,J.F.;Akdemir,Ö.;Hoth,A.PointbypointcomparisonoftwothermosensitivepolymersexhibitingasimilarLCST: istheageofpoly(NIPAM)over. J. Am. Chem. Soc. 2006 , 128 ,13046−13047..

Wu,C.;Zhou,S.Thermodynamicallystableglobulestateofasinglepoly( N -isopropylacrylamide)chaininwater. Macromolecules 1995 , 28 ,5388−5390..

Gibson,M.I.;O'Reilly,R.K.Toaggregate,ornottoaggregate?Considerationsinthedesignandapplicationofpolymericthermally-responsivenanoparticles Chem. Soc. Rev. 2013 , 42 ,7204−7213..

Xing,S.;Guan,Y.;Zhang,Y.Kineticsofglucose-inducedswellingofP(NIPAM-AAPBA)microgels. Macromolecules 2011 , 44 ,4479−4486..

Tang,Z.;Guan,Y.;Zhang,Y.J.Contraction-typeglucose-sensitivemicrogelfunctionalizedwitha2-substitutedphenylboronicacidligand. Polym. Chem. 2014 , 5 ,1782−1790..

Huang,N.;Guan,Y.;Zhu,X.X.;Zhang,Y.Swellingkineticsofmicrogelsembeddedinapolyacrylamidehydrogelmatrix. ChemPhysChem 2014 , 15 ,1785−1792..

Jiang,L.;Yang,T.;Peng,L.;Dan,Y.Acrylamidemodifiedpoly(vinylalcohol):crystallineandenhancedwatersolubility. RSC Adv. 2015 , 5 ,86598−86605..

Saadiah,M.A.;Zhang,D.;Nagao,Y.;Muzakir,S.K.;Samsudin,A.S.ReducingcrystallinityonthinfilmbasedCMC/PVAhybridpolymerforapplicationasahostinpolymerelectrolytes. J. Non-Cryst. Solids 2019 , 511 ,201−211..

Huang,D.;Gao,S.;Luo,Y.;Zhou,X.;Lu,Z.;Zou,L.;Hu,K.;Zhao,Z.;Zhang,Y.Glucose-sensitivemembranewithphenylboronicacid-basedcontraction-typemicrogelsaschemicalvalves. J. Membr. Sci. 2022 , 650 ,120406..

Zou,L.;Su,B.;Addonizio,C.J.;Pramudya,I.;Webber,M.J.Temperature-responsivesupramolecularhydrogelsbyternarycomplexformationwithsubsequentphoto-cross-linkingtoalternetworkdynamics. Biomacromolecules 2019 , 20 ,4512−4521..

Tang,L.;Wang,L.;Yang,X.;Feng,Y.;Li,Y.;Feng,W.Poly( N -isopropylacrylamide)-basedsmarthydrogels:design,propertiesandapplications. Prog. Mater. Sci. 2021 , 115 ,100702..

Saunders,B.R.;Vincent,B.Microgelparticlesasmodelcolloids:theory,propertiesandapplications. Adv. Colloid Interface Sci. 1999 , 80 ,1−25..

Guan,Y.;Zhang,Y.Progressinthestudyofmicrogelcolloidalcrystals . Acta Polymerica Sinica (inChinese) 2017 ,48,1739-1752..

Musch,J.;Schneider,S.;Lindner,P.;Richtering,W.Unperturbedvolumetransitionofthermosensitivepoly( N -isopropylacrylamide)microgelparticlesembeddedinahydrogelmatrix. J. Phys. Chem. B 2008 , 112 ,6309−6314..

浏览量

306

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Strong and Tough Composite Hydrogels with Crack-deflecting Ability Enabled by a Viscoelastoplastic Mixing Strategy

Interferometers Utilizing Reversible X-ray-induced Chemical Changes in Poly(N-isopropylacrylamide) Microgels

Epoxy-functionalized Cyclohexane-based Ricinoleate Plasticizer: Synthesis, Performance Evaluation, and Plasticizing Mechanism

Improvements of Hydrophobicity and Toughness of Epoxy Coatings Modified with Hydroxyl-terminated Fluororubber

A Paradigm for BF3 Co-initiated Cationic Polymerization with Low Dispersity: Introducing Acetonitrile and Lowering the Reaction Temperature